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녹차에 의한 알코올성 위염 예방 효과에 대한 분자 생물학적 기전
이정상 ( Lee Jeong Sang ),오태영 ( O Tae Yeong ),함기백 ( Ham Gi Baeg ),박수진 ( Park Su Jin ),송영준 ( Song Yeong Jun ),이은희 ( Lee Eun Hui ),이광재 ( Lee Gwang Jae ),유병무 ( Yu Byeong Mu ),김진홍 ( Kim Jin Hong ),김영경 ( Kim 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
알코올성 위염은 임상에서 흔히 접하는 질환으로 알코올은 위에서 위염, 위궤양 및 위암의 원인으로 작용한다. 그런데 알코올성 위염은 알코올의 위점막 손상에 대한 정확한 분자 생물학적 규명이 되어 있지 못하고, 따라서 특이한 치료 방법이 없는 실정이다. 녹차 (Green Tea)는 falvonoid 중 가장 다양한 보호 효과가 규명되어 각종 염증 질환은 물론 암예방 물질로써 각광을 받고 있다. 이의 작용 기전으로는 항염증 작용, 암세포의 증식 억제 효과 및
만성신부전에서 염류코르티코이드 투여가 포타시움 평형과 요 암모늄 배설에 미치는 효과
한진석(Jin Suk Han),이정상(Jung Sang Lee),김강석(Kang Seock Kim),허우성(Woo Seong Huh),전은실(Un Sil Jeon),이서진(Seo Jin Lee),주권욱(Kwon Wook Joo),김성권(Suhnggwon Kim),진호준(Ho Jun Chin),조윤숙(Yun Suk Cho) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.2
N/A Mineralocorticoids influences on acid-base homeo-stasis by the regulation of urine acidification. But its mechanism of acion is not well known in human. This study compared the acid-base status and the indices of urine acidification before and after mineralocorticoid administration in human, and analyzed the effect of mineralocorticoids on human acid-base homeostasis. We administered 9a-fludrocortisone in 6 chronic renal failure patients and 6 normal controls 0.5mg daily for 7 days. The results were as following ' 1) After administration of 9a-fludrocortisone in patients group, serum aldosterone level changed from 120.2±71.0pg/mL to 44.8±32.2pg/mL(mean±SD, p< 0.05). Serum HCO- level was not changed. Urine ammonium excretion was incresed from 24.6±12.3 mmol/day to 43.7±19.0(p<0.05), but there were no change in urine pH and urine anion gap, Serum potassium level decreased from 5.5±0.7mBq/L to 4.1±0.5mEq/L(p<0.05), and TTKG increased from 3.9 to 8.9(p<0.05). 2) After administration of 9a-fludrocortisone in control group, serum aldosterone level changed from 99.7±44.5pg/mL to 25.1±3 mL(p<0.05). Serum HCO- level was not changed. Urine ammonium ex-cretion was incresed from 44.3±21.6mmoVday to 76.3±19.6(p<0.05), but there were no change in urine pH and urine anion gap. Serum potassium level decreased from 4.8±0.5mEq/L to 3.9±0.2mHq/L(p< 0.05), but there was no change in TTKG. 3) No patient or control showed any discomfort after 9-fludrocortisoneadministration, and there was no elevation in diastolic blood pressure, increase in body weight, electrolyte abnormality. In summary, after 9α-fludrocortisane administration, urinary ammonium excretion increased in both patients and control group, and this phenomenon occured with correction of hyperkalemia without urine pH change. This result implies urinary ammonium excretion increase by mineralocorticoid. In human increase in renal distal acidification by mineralocorticoid is due to increase in renal ammo- niagenesis rather than stimulation on proton excretion.
요 삼투질농도차를 이용한 요 암모늄 배설의 평가 : 요 음이온차와 비교
김근호(Gheun Ho Kim),전은실(Eun Sil Jun),허우성(Woo Sung Huh),김연수(Yon Su Kim),안규리(Cu Rie Ahn),한진석(Jin Suk Han),김성권(Suhng Gwon Kim),이정상(Jung Sang Lee) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Objectives: Urine osmolal gap(UOG) and urine anion gap(UAG) have been suggested for the indirect measures of urine NH4+ excretion. The clinical usefulness of UOG in the patients with urine acidification defect is much less known in comparison with that of UAG. Methods: We measured UOG[=urine osmolality-{2(Na++K+)+urea}] and compared with urine NH4+ and UAG(=Na+ +K+ -Cl- ) in 5 patients with distal renal tubular acidosis patients(RTA) and 8 healthy adults with acid loading(NC), whose arterial blood bicarbonate concentrations were 19.5±1.6mM (mean+SEM) and 19.6±0.6mM, respectively. Results: Urine NH4+ excretory rate of RTA(26.8±4.9mmol/day) was lower(p<0.01)than that of NC (52.6±3.7mmol/day), UOG of RTA(129.7±17.0mM) was lower(p<0.05) than that of NC(319.7±58.4mM), and UAG of RTA(52.2±9.4mM) was higher(p<0.01)than that of NC(-16.2±5.5mM). Urine osmolality had good correlations with the sum of major urinary solutes calculated by 2(Na+ + K+ +NH4+)+urea in spot urine(r=0.90, p<0.01) and 24- hour urine collection(r=0.95, p<0.01). UOG had positive correlations with spot urine NH4+ concentration(r=0.97, p<0.01) and 24 hour urine NH4+ excretion(r=0.69, p=0.01). UAG had inverse correlations with spot urine NH4+ concentration(r=-0.78, p<0.01) and 24-hour urine NH4+ excretion(r=-0.75, p<0.01). The lower urine NH4+ in RTA was reflected by the lower UOG(<150mM) and the higher UAG(>5mM). Conclusion: Urine osmolal gap as well as urine anion gap was a useful clinical index reflecting urine ammonium in the patients with distal renal tubular acidosis, and urine osmolal gap below 150mM and urine anion gap above 5mM would suggest the impaired urine ammonium excretion.
김형호(Hyoung-Ho Kim),박준길(Jun-Gil Park),서상호(Sang-Ho Suh),이정상(Jeong-Sang Lee),최재성(Jae-Sung Choi) 대한기계학회 2011 대한기계학회 춘추학술대회 Vol.2011 No.4
협착이 발생된 관상동맥의 치료를 위해 외과적인 수술방법으로는 이식우회로술이 많이 사용된다. 이식우회로술 시술 시 개존률 향상을 위해서는 최적의 혈관 문합 시술에 대한 연구가 필요하다. 본 연구의 목적은 γ-grafting bypass와 T-graft ing bypass 시술의 효과를 분석하는 것이다. 이를 위해 기하학적 형상을 최적화하고 각각의 기하학적 형상에 대해 혈류역학적 특성을 비교분석하였다. 이 연구를 위해 유한체적법을 기반으로 하는 상용코드를 이용하여 시뮬레이션을 수행하였다. Bypass anastomosis is frequently adopted for surgical treatments in stenosed coronary artery. Optimal coronary bypass grafting should be investigated to improve the patency for the arterial bypass techniques. The objective of this study is to analyze the effects of the Y-grafting bypasses and T-grafting bypasses. In order to find the optimal geometric configuration, the hemodynamic characteristics are obtained and compared with each other for different geometries. The study is performed with a general-purpose CFD code, which is based on the finite volume discretization.