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Efficacy of Modified Rush Allergen-Specific Immunotherapy on Canine Atopic Dermatitis
이왕희,박성준 韓國臨床獸醫學會 2017 한국임상수의학회지 Vol.34 No.4
Modified rush ASIT protocol has been performed to identify the ideal schedule that allows the dose considered effective to be reached in the shortest possible time with the fewest adverse effects. Ten atopic dogs of this study includes fulfillment of Favrot’s criteria. Offending allergens were identified by the use of IDST. During the induction period, the dogs were received a total of 15 injections. Ten injections were administrated every 30 minutes in a day with gradually increasing amounts and concentrations of allergens, and the last 5 injections were administered every 3 days. Disease severity was quantified by using the canine atopic dermatitis extent and severity index (CADESI). During induction period, reduction rate from baseline scores varied between 1% and 67% and the improvement of ≥ 50% was recorded after induction period of therapy for CADESI-03 score in 6 of the 10 dogs. This study of ten dogs with atopic dermatitis provide evidence for the efficacy and safety of modified rush ASIT for clinical improvement.
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Mechanistic Modeling in Biosystem Engineering: A Review on Mechanistic Models of Calcium Metabolism
이왕희,조병관 한국산업식품공학회 2013 산업 식품공학 Vol.17 No.1
Calcium is an essential nutrient generally obtained from dietary foods. However, its metabolism is a complex biological network requiring an effective analytical tool. In this review, a few notable calcium mechanistic models are assessed, emphasizing the power of mechanistic modeling in analyzing biological systems because no publication has reviewed them in a single place. Reviewed models are categorized by target systems: calcium absorption, calcium excretion, bone turnover, and whole calcium homeostasis. In the calcium absorption model, two transport systems carrying calcium from intestine to blood have been mechanistically described. Since urine calcium excretion is poorly understood, its model has not been explicitly developed although it is modeled as a part of the whole calcium metabolic system. Cell-based bone turnover model has been conceived to describe the mechanism under bone cell regulation. Finally, whole calcium metabolism has been a target to explain the metabolic control of calcium homeostasis that is linked to the endocrine system. Reviewed models focus on explaining how the calcium metabolic system behaves in response to conditional perturbations by involving effective factors such as endocrine system. We expect that not only will this study provide comprehensive information for future studies in calcium metabolism, but also that it will suggest what the concepts of biosystem modeling are and how they can be used for assessing the target system.
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이왕희,오일남,최승현,박종태 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.10
Food authenticity is one of the largest concernsin recent days. As kimchi has been a global food, its productionorigin has been important issue, particularly due tothe large import from China. Among the potential methods,electronic nose which can measure volatile compounds infoods is considered to be a powerful device for identifyingcountry of production. This study is to classify 69 kinds ofkimchi produced in South Korea (39) and China (30) byanalyzing volatile compounds in kimchi using electronicnose-mass spectrometry. Two widely used multivariateanalyses, discriminant function analysis and principalcomponent analysis, were used. Results showed that bothmultivariate analyses can completely separate Korean andChinese kimchi using 10 kinds of molecular weightsamong 10–160 amu. The results indicate that the volatilecompounds in kimchi are a suitable target to determine thegeographical origin of kimchi.
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이왕희,최승현,오일남,심준용,이광식,안길환,박종태 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.3
An electronic nose-mass spectrometry (EN-MS) that profiles volatile compounds is a candidate device for identifying the geographic origin of cultivation of agricultural products when an adequate algorithm is derived. The objectives of this study were to apply two types of multivariate analysis, discriminant function analysis (DFA) and principal component analysis (PCA), to the volatile compounds detected by an EN-MS for the geographic classification of Chinese cabbage cultivated in Korea (42 samples) or in China (29 samples). DFA showed that Chinese cabbage from Korea were completely separable from those originating in China with 12 volatile compounds among the 151 detected. PCA revealed that Chinese cabbage data fell into two completely separable origins of Korea and China. This is the first study involving EN-MS data of volatile compounds with multivariate statistics to discriminate the geographical origin of Chinese cabbage, with further applications for other agricultural products.
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