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Mechanistic Modeling in Biosystem Engineering: A Review on Mechanistic Models of Calcium Metabolism
이왕희,조병관 한국산업식품공학회 2013 산업 식품공학 Vol.17 No.1
Calcium is an essential nutrient generally obtained from dietary foods. However, its metabolism is a complex biological network requiring an effective analytical tool. In this review, a few notable calcium mechanistic models are assessed, emphasizing the power of mechanistic modeling in analyzing biological systems because no publication has reviewed them in a single place. Reviewed models are categorized by target systems: calcium absorption, calcium excretion, bone turnover, and whole calcium homeostasis. In the calcium absorption model, two transport systems carrying calcium from intestine to blood have been mechanistically described. Since urine calcium excretion is poorly understood, its model has not been explicitly developed although it is modeled as a part of the whole calcium metabolic system. Cell-based bone turnover model has been conceived to describe the mechanism under bone cell regulation. Finally, whole calcium metabolism has been a target to explain the metabolic control of calcium homeostasis that is linked to the endocrine system. Reviewed models focus on explaining how the calcium metabolic system behaves in response to conditional perturbations by involving effective factors such as endocrine system. We expect that not only will this study provide comprehensive information for future studies in calcium metabolism, but also that it will suggest what the concepts of biosystem modeling are and how they can be used for assessing the target system.
이왕희,오일남,최승현,박종태 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.10
Food authenticity is one of the largest concernsin recent days. As kimchi has been a global food, its productionorigin has been important issue, particularly due tothe large import from China. Among the potential methods,electronic nose which can measure volatile compounds infoods is considered to be a powerful device for identifyingcountry of production. This study is to classify 69 kinds ofkimchi produced in South Korea (39) and China (30) byanalyzing volatile compounds in kimchi using electronicnose-mass spectrometry. Two widely used multivariateanalyses, discriminant function analysis and principalcomponent analysis, were used. Results showed that bothmultivariate analyses can completely separate Korean andChinese kimchi using 10 kinds of molecular weightsamong 10–160 amu. The results indicate that the volatilecompounds in kimchi are a suitable target to determine thegeographical origin of kimchi.
이왕희,조병관 한국농업기계학회 2012 바이오시스템공학 Vol.37 No.4
Purpose: This review aims at introducing 3 modeling approaches classified into 3 categories based on the purpose (estimation or prediction), structure (linear or non-linear) and phase (steady-state or dynamic-state); 1) statistical approaches, 2) kinetic modeling and 3) mechanistic modeling. We hope that this review can be a useful guide in the model-based approach of calcium metabolism as well as illustrates an application of engineering tools in studying biosystems. Background: The meaning of biosystems has been expanded, including agricultural/food system as well as biological systems like genes, cells and metabolisms. This expansion has required a useful tool for assessing the biosystems and modeling has arisen as a method that satisfies the current inquiry. To suit for the flow of the era, examining the system which is a little bit far from the traditional biosystems may be interesting issue, which can enlarge our insights and provide new ideas for prospective biosystem-researches. Herein, calcium metabolic models reviewed as an example of application of modeling approaches into the biosystems. Review: Calcium is an essential nutrient widely involved in animal and human metabolism including bone mineralization and signaling pathways. For this reason, the calcium metabolic system has been studied in various research fields of academia and industries. To study calcium metabolism, model-based system analyses have been utilized according to the purpose, subject characteristics, metabolic sites of interest, and experimental design. Either individual metabolic pathways or a whole homeostasis has been modeled in a number of studies.
이왕희,최승현,오일남,심준용,이광식,안길환,박종태 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.3
An electronic nose-mass spectrometry (EN-MS) that profiles volatile compounds is a candidate device for identifying the geographic origin of cultivation of agricultural products when an adequate algorithm is derived. The objectives of this study were to apply two types of multivariate analysis, discriminant function analysis (DFA) and principal component analysis (PCA), to the volatile compounds detected by an EN-MS for the geographic classification of Chinese cabbage cultivated in Korea (42 samples) or in China (29 samples). DFA showed that Chinese cabbage from Korea were completely separable from those originating in China with 12 volatile compounds among the 151 detected. PCA revealed that Chinese cabbage data fell into two completely separable origins of Korea and China. This is the first study involving EN-MS data of volatile compounds with multivariate statistics to discriminate the geographical origin of Chinese cabbage, with further applications for other agricultural products.