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이영준,이상배,박민철,이화정,인창식,Lee, Young Jun,Lee, Sang-bae,Park, Min-Cheol,Lee, Hwa Jeong,Yin, Chang Shik 턱관절균형의학회 2015 턱관절균형의학회지 Vol.5 No.no.sup
본 증례에서는 극심한 삼차신경통 진단을 받고 안면부와 턱관절 통증으로 일상생활이 어려워 항간질약과 수술적 치료를 받았지만 통증이 개선되지 않던 환자에게서 음양균형장치를 포함한 자세조절훈련, 침치료 등 구조적 치료를 통해서 유의한 자각적 증상 개선뿐만 아니라 턱관절의 구조적 개선이 나타남을 관찰하였고, 요통과 경항통 및 비염 같은 제반 증상들의 호전과 척추의 구조적 개선이 관찰되었다. Therapeutic effect of Yinyang Balancing Appliance (YBA) of functional cerebrospinal therapy (FCST) for meridian and neurologic yinyang balance was observed in a trigeminal neuralgia case. One Trigeminal neuralgia case was managed with YBA on temporomandibular joint (TMJ), combined with acupuncture. Clinical outcome measurement was performed by subjective rating and clinical observations. The patient's subjective rating and clinical symptoms showed improvement immediately after the initial treatment and this improvement maintained over the follow-up period. Although it is not clear whether the effect is temporary in its nature, a positive effect was observed and further clinical and biological research on FCST is expected.
삼초(三焦)의 '협관계(協關系)' 관점에서 본 측두하악관절(側頭下顎關節)에 대한 고찰
이영준,이종수,이한성,Lee, Young-Jun,Lee, Jong-Soo,Lee, Han-Sung 척추신경추나의학회 2005 대한추나의학회지 Vol.6 No.1
Objectives : The aim of this study was to try to embody the method of treating Tempromandibular Joint Disorder in Oriental Medicine. Methods : I had researched anatomic features and functions of TMJ, causes and symptoms of TMD and reviewed classic medicine books in Oriental Medicine on Sanjiao. Then, I tried to interpret the disorder in the point of Sanjiao's 'Cooperative Relationship'. Results and Conclusions : 1. Symptoms of TMD IS not limited at TMJ and spread in whole body by circulation of Sanjiaojing. 2. Sanjiao is a invisible organ to control the general physical functions as 'Cooperative Relationship'. 3. It is a due in improving the symptoms of TMD to regulate Sanjiao-Jing-qi and balance the Yin-Yang.
이영준,구세광,강수진,Lee, Young-Joon,Ku, Sae-Kwang,Kang, Su-Jin 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.2
Objectives : Many cancers acquired resistance to chemotherapy, thus limiting its anticancer efficacy. It is known that Glutathione (GSH) is related to the development of drug resistance. The expression of GSH synthesizing glutamylcysteine ligase (GCL) was controlled by nuclear factor-E2-related factor(Nrf2). Previous studies showed that pharmacological depletion of GSH results in ROS increase, apoptotic response, and sensitization to oxidizing stimuli. In the current study, we examined Saussurea Lappa (SL) have the inhibitory effect on Nrf2 activity using human lung cancer A549 cells overexpressing Nrf2. Methods : Cell viability of A549 cells on SL treatment was determined by MTT assay. To detect the apeptosis in SL-treated A549 cells, sub-G1 population was measured by flow cytometry analysis (FACS). The level ROS was determined by FACS and fluorescence microscopy. To investigate whether SL have effect the suppression on Nrf2, we performed western blotting analysis. The GSH content was measured since GSH plays an important role in response to oxidative stress and was regulated by Nrf2. Results : A549 cells treated with an SL extract showed a substantial decrease in cell viability, along with a concomitant increase in apoptosis compared to untreated cells. Treatment of the SL extract led to increased Reactive oxygen species (ROS) production and a suppression of Nrf2. In addition, the antioxidant NAC attenuated SL-induced ROS generation, Nrf2 inhibition, and apoptosis. Taken together, these data show that the SL extract induced the production of ROS, and the inhibition of Nrf2, consequently resulting in A549 cell death. Conclusions : These results suggest that SL might be an effective agent to enhance anticancer drug sensitivity via Nrf2 inhibition.
연구원_2015 연구과제 ⑦ - 기계설비건설업 관련법규 개선방안 연구
이영준,한성애,박종일,Lee, Yeong-Jun,Han, Seong-Ae,Park, Jong-Il 대한기계설비건설협회 2016 기계설비 Vol.310 No.-
대한기계설비산업연구원(원장 이언구)은 지난해 4월 연구심의위원회에서 선정된 ${\triangle}$기계설비건설업 동향분석을 위한 기초연구 ${\triangle}$기계설비건설업체의 부도예측 모형 연구 ${\triangle}$기계설비건설공사 시공상세도면 작성비 산정기준 연구 ${\triangle}$플랜트 건설현장 외국인력 고용 개선방안 ${\triangle}$녹색기술 기준에 근거한 연구과제 도출을 위한 기초연구 ${\triangle}$대용량 지열설비 이용을 위한 지중열교환기 용량 설계 툴 개발 ${\triangle}$기계설비배관 및 장비 단열 기준 연구 등의 기본과제와 외부기관과 공동으로 수행한 ${\triangle}$플랜트 건설현장 외국인력 고용 개선방안 ${\triangle}$기계설비건설업 관련법규 개선방안 연구를 추진했다. 지난 2월호에 시작된 연구원의 연구결과 요약 보고서는 이번호로 연재를 마친다.
속단의 dichloromethane 분획물이 태아골모세포의 골형성 유도에 미치는 효과
이영준,최희인,김윤철,신형식,유형근,Lee, Young-Joon,Choi, Hee-In,Kim, Yun-Chul,Shin, Hyung-Shik,You, Hyung-Keun 대한치주과학회 2003 Journal of Periodontal & Implant Science Vol.33 No.2
The ideal goal of periodontal therapy is the regeneration of periodontal tissue repair of function. Although is very difficult to attain the goal, recent advances in periodontal wound healing concepts encourage hope reaching it. Recently many efforts are concentrated on the regeneration potential of material used in traditional Korean medicine. Phlomidis Radix has been used for the treatment of blood stasis, bone fracture and osteoporosis in traditional Korean medicine. The purpose of this study is to examine effects of dichloromethane fraction Phlomidis Radix on Bone Formation in Human Fetal Osteoblasts. Human fetal osteoblastic cell line(hFOB1 1.19 ;American Type Culture Collection, Manassas, VA) were used and cells were cultured containing DMEM and dichloromethane fraction Phlomidis Radix(100 ng/ml , 1 ${\mu}$/ml, 10 ${\mu}$/ml) at 34$^{\circ}C$ with 5% $CO_2$ in 100% humidity. MTT was performed to examine the viability of the cell, and alkaline phosphatase activity was analyzed to examine the mineralization. Also bone calcification nodules were evaluated. The cellular activity of hFOB1 was increased in 100 ng/ml, 1 ${\mu}$/ml , 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix and especially significant increation was showed in 100 ng/ml of dichloromethane fraction of Phlomidis Radix at 6days (p <0.05). ALP level of hFOB1 was significantly increased in 100 ng/ml , 1 ${\mu}$/ml, 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix and especially more increation was showed in 10 ${\mu}$/ml of dichloromethane fraction of Phlomidis Radix (p <0,05). Calcification nodules of hFOB1 significantly increased in 10 ${\mu]$/ml of dichloromethane fraction of Phlomidis Radix at 21 days of incubation(p<0.05). The results indicate that dicholoromethane fraction of Phlomidis Radix has excellent effects on mineralization of hFOB1.
이영준,Lee, Yeong-Jun 대한출판문화협회 1997 출판저널 Vol.221 No.-
대개 인물사진 속에서 인물의 시선은 카메라 시선과 일치하거나 거부하는 대결을 보인다. 그러나 책이 등장할 때 책 읽는 인물의 시선은 강렬하게 책 속에 파묻혀 있다. 책을 읽을 때의 시각적 경험이 생각보다 훨씬 강렬하고 진지한 것임을 말해주는 것이다.
Effects of Hydraulic Retention Time on Hydrogen Production
이영준,Lee, Young-Joon Korean Society of Environmental Health 2005 한국환경보건학회지 Vol.31 No.4
연속반응조에서의 수소생산에 대한 수리학적체류시간(희석율, D)의 영향을 $1\%$ sucrose를 함유한 $37{\pm}1^{\circ}C$ 조건에서 조사하였다. 실험결과 수리학적체류시간(희석율)의 각각의 조건에 따라 생성된 가스중 수소성분은 $50~71\%$의 범위로 발생되었다. $H_2/CO_2$ 비율은 희석율이 증가할 때 $H_2/CO_2$ 비율도 증가하였다. 최대수소생성 수율은 희석율 0.14 l/h까지는 증가하다가 이후에는 감소하였고, 수소생성 수율은 0.81 l/g sucrose이었다. Acetate 생성 수율은 butyrate생성 수율 보다 희석율 조건변화에 민감하게 변화하였다. propionate 및 solvents는 희석율 변화에 영향을 받지 않았다 biomass 수율은 희석율이 0.2 l/h 까지는 증가하였으나, 그 이상의 조건에서는 감소하였다.