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A Review of Exercise Intervention Research on Timing of Treatment in Cancer Patients
이시은 한국체육과학회 2024 한국체육과학회지 Vol.33 No.2
Surgery and adjuvant chemotherapy are common treatments for many cancer patients, and these treatments are associated with side effects. Exercise has been reported to be an effective way to reduce side effects during and after treatment for cancer patients. Regular exercise has been demonstrated to enhance muscle strength, diminish fatigue, and alleviate energy depletion, a prevalent side effect of chemotherapy. This treatment also improves patients' overall physical well-being. Additionally, exercise exerts a direct impact on tumour suppression and immune system strengthening. The efficacy of adjuvant chemotherapy in cancer patients can be enhanced by the incorporation of an appropriate exercise programme. Further investigation is required to elucidate the specific types and intensity of exercise that are most beneficial for cancer patients. The development of bespoke exercise programmes by healthcare providers can effectively support cancer patients in managing their treatment and improving their overall quality of life. Additionally, research has indicated that exercise can enhance the efficacy of chemotherapy and other cancer treatments. Despite these promising findings, there is a paucity of research on exercise interventions according to the timing of chemotherapy in Korea. The objective of this study is to analyse the effects of exercise interventions following surgery, during and after chemotherapy, and to investigate the potential of exercise as a treatment for cancer patients.
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이시은,안덕선,이영호 대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3
Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca2+ channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca2+]i were measured simultaneously in the longitudinal strips of female Sprague-Dawley rats late in their pregnancy (on day 18∼20 of gestation: term=22 days). The expression of T-type Ca2+ channel mRNAs or protein levels was measured. Cumulative addition of low concentrations (<1μM) of nifedipine, a L-type Ca2+ channel blocker, produced a decrease in the amplitude of the spontaneous Ca2+ transients and contractions with no significant change in frequency. The mRNAs and proteins encoding two subunits (α1G, α1H) of the T-type Ca2+ channels were expressed in longitudinal muscle layer of rat myometrium. Cumulative addition of mibefradil, NNC 55-0396 or nickel induced a concentration-dependent inhibition of the amplitude and frequency of the spontaneous Ca2+ transients and contractions. Mibefradil, NNC 55-0396 or nickel also attenuated the slope of rising phase of spontaneous Ca2+ transients consistent with the reduction of the frequency. It is concluded that T-type Ca2+ channels are expressed in the pregnant rat myometrium and may play a key role for the regulation of the frequency of spontaneous phasic contractions.
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이시은 전북대학교 동북아법연구소 2018 동북아법연구 Vol.12 No.2
로마법에서 근대법에 이르기 까지, 특히 19세기 산업혁명이 발생하기 이전, 인류는 토지를 이용함에 있어 일반적으로 지표를 주로 이용하며 토지 상하에 걸쳐 토지소유권을 행사하였다. 토지소유자는 자신이 소유한 토지의 지표를 중심으로 상하 모든 범위의 배타적 지배권을 가진다. 각국 입법(주로 민법)은 토지소유자에게 이와 같은 광범위한 권리를 부여하였다. 토지의 횡적인 소유 및 이용만을 규율하던 토지소유권 및 토지사용권에서 벗어나 토지의 종적, 특히 공간을 객체로 하는 현대적 의미의 공간권 개념은 토지를 2차원적 개념에서 3차원적 개념으로 변하게 하였다. 미국을 시작으로 공간권 개념이 출현하면서 우리나라의 경우 1980년대 중반부터 공간권에 관한 이론은 소개되어 왔으나 엄밀한 의미에서 공간권의 이용사례가 없기 때문에 생소한 개념이었다. 중국은 2007년 물권법을 제정하면서 건설용지사용권이라는 용어를 도입하였고, 토지소유권으로부터 토지사용권을 독립한 물권으로 분리하면서 토지의 상하층을 분리하는 규정을 내놓았다. 이는 공간에 대한 재산권을 강화화기 위한 법률적 필요성에 따른 것이다. 중국은 경제가 발달한 도시를 중심으로 지하공간을 개발·이용할 필요가 있었고, 급속한 경제성장으로 경제적 및 기술적 조건을 이미 갖추게 되었다. 이에 따라 국토 자원 행정주관 부문에서도 지하공간권의 재산권 관리와 관련한 규범을 조속히 제정하려는 노력을 보이고 있다. 지하공간이 희소성을 가진 토지자원이 되었을 때를 대비해 재산권 관계를 입법을 통해 명확히 할 필요가 있는 것이다. 자원절약형 사회를 건설하기 위하여 지하공간의 개발·이용을 규율하고, 지하 공간 자원의 지속가능한 이용을 추진하며 다양하게 형성된 지하공간의 재산권 관리와 관련하여 중국 특유의 입법을 위한 연구가 활발히 이루어지고 있는 실정이다. 본 연구는 공간권의 대상인 공중, 지중 중 지중부분인 지하공간을 중심으로 한다. 우리나라에서도 활발히 논의되고 있는 지하고속도로, SRT 사업 등 고도 경제 성장 이후 급격히 진행된 도시화를 극복하기 위한 방법을 모색하는 점에서는 지하공간을 활용하고자 하는 노력은 비단 한국만의 문제가 아닌 전세계적 추세로서 그 중 고속 경제성장 과정에 있는 중국의 지하공간 이용률의 급증은 괄목할 만 하다. 이러한 사회적 현상을 바탕으로 본 논문은 중국의 현 지하공간관련 법률제도 및 제 문제점을 탐구하고자 한다. From Roman law to modern law, especially before the industrial revolution of the 19th century, human beings generally used surface in land use and exercised land ownership over land. In the sense that there was only one ownership or right to use on a single land, the concept of modern spatiality means that human land legislation has been converted from plane to three-dimensional space. With the emergence of the theory of Air Space Right starting with the U.S., the theory of Air Space Right has been introduced in Korea since the mid-1980s, but it was an unfamiliar concept since there were no cases of the use of the right. In 2007, when the Act was enacted, China introduced the term "Construction Land Use Right" and introduced regulations that separate the upper and lower levels of land from land ownership into the independent property rights. This is in line with the legal necessity to strengthen property rights in space. According to the legal necessity of strengthening property rights in underground spaces, areas with developed Chinese economy already have the economic and technical conditions necessary to develop and use underground spaces. The national territory resource administration is also making efforts to establish regulations as soon as possible regarding the management of property rights for underground space use. In the event that underground space becomes a scarce land resource, the relationship of property rights should be clarified through legislation. Research for legislation in relation to the management of the property rights of various underground spaces is actively carried out by regulating the development and use of underground space, promoting sustainable use of underground space resources, and establishing a resource-saving society. This study focuses on underground space, which is the subject of space, in the air space and in the underground space. In terms of finding ways to overcome the rapid urbanization of high-level economic growth, such as the high-speed underground road and the SRT project, China's efforts to utilize underground space is not a problem of Korea alone but a global economy. Based on this social phenomenon, this paper explores the current legal system and problems related to underground space in China.
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이시은,심유진,김아람,최승욱 한국체육과학회 2023 한국체육과학회지 Vol.32 No.4
Gastric cancer is a major global health problem in East Asian countries. Although anticancer drugs can have beneficial effects in treating cancer, they can exacerbate chemotherapy side effects and cachexia symptoms in gastric cancer patients. Various side effects reduce the patient's quality of life, and experts report that quality of life should be improved as a key factor in treatment decisions. Therefore, this study aims to examine the relationship between myokine secreted from muscles, anticancer side effects, and quality of life. Side effects, quality of life, and myokine were measured twice during the period of chemotherapy in 9 subjects. As a result, there was no correlation between myokine and side effects, but there was a correlation between overall function and cognitive function in quality of life. It is considered that a large-scale study subject and mechanism study on myokine are needed in the future.
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