유리체절제술의 학습곡선

이성진,박수은,Sung Jin Lee,Su Eun Park 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: To determine the learning curve of surgeons who perform vitrectomy by studying the results of the first 500 vitrectomy cases that were performed after a fellowship training course for a retina surgeon. Methods: The medical records of the first 500 vitrectomy cases performed by a retina surgeon from February 2001 were reviewed. We included the first operation of each eye and excluded partial vitrectomy and ocular laceration cases. We defined failure as reoperation cases within 3 months and cases with serious visual complication. Results: There were 261 eyes (52.2%) from male patients, and 239 eyes (48.7%) from female patients; the average age was 59.7 years old. The causative diseases were, in order of frequency, proliferative diabetic retinopathy, retinal detachment, and branch retinal vein occlusion. The final visual outcomes showed improvement of more than 2 lines in 274 eyes (54.8%), and a decrease of more than 2 lines in 50 eyes (10.0%). Failure was the outcome in 37 eyes (7.4%) and was more frequent in the first 2 years of surgeries; the causes of failure were, in order of frequency, retinal detachment, vitreous hemorrhage, and neovascular glaucoma. Visual acuity in the first 2 years, during which failure was more frequent, was not different from that in the last 3 years. Conclusions: To achieve consistently stable results in vitrectomy, a newly trained retina surgeon needs about 150 cases of vitrectomy or 2 years of experience.

고정식 자켓구조물 용접이음부 응력집중계수 평가

이성진,문현기,경갑수 한국구조물진단유지관리학회 2011 한국구조물진단학회 학술발표회논문집 Vol.2011 No.9

Circular tubular connection fabricated by welding become to be a vulnerable structure for fatigue in servicing by the affect of the geometric shape. It is necessary to improve the safety with evaluating SCF(Stress Concentration Factor) for the connections of offshore structure. In order to offer basic data using in evaluation of SCF for welded connections with complex shape, in this study, we investigated relationship between shape factor and SCF in simple K-type cross section.

사상체질집단의 ADPRT gene 3'UTR region의 단일염기다형성 연구

이성진,송일병,이수경,Lee, Sung-Jin,Song, Il-Byung,Lee, Su-Kyung 사상체질의학회 2002 사상체질의학회지 Vol.14 No.2

Sasang Constitutional Medicine is based on the diversity of human being and medically developed the variation of response to diseases and medicines. The diversity is categorized as four groups Taeyangin, Taeumin, Soyangin, Soeumin according to morphology, physiology, pathology, and pharmacology. The phenotypes of Sasang constitutions represent that constitutions may be possessed of the different genetic backgrounds. To clarify the genetic difference among the Sasang constitutions, we performed a genetic analysis with the 3'-UTR polymorphism of ADPRT (rs=8679) as a pooled DNA sequencing method. ADPRT modulates various nuclear proteins by poly(ADP-ribosy)lation and is involved in the regulation of various cellular processes such as differentiation, proliferation, and tumor transformation. This gene is also involved in the recovery of cell from DNA damage and the brain infarction. The allele frequencies of [T/C] polymorphism of ADPRT of Soeumin and Soyangin groups were (T: 0.94/C: 0.06) and that of Taeumin and Taeyangin groups were (T: l.00/C: 0.00). The allele frequency was not showed the difference between constitution groups. This result represented that the [T/C] polymorphism of ADPRT 3' UTR region was not suitable to classify the constitutions. However, this study is the first trial of Sasang classification according to genetic polymorphism and further analysis will be necessarily to classify the genetic difference of Sasang constitution.

홍화인 추출물이 골 형성에 미치는 영향에 관한 실험실적 연구

이성진,최호철,선기종,송제봉,피성희,유형근,신형식,Lee, Seong-jin,Choi, Ho-Chul,Sun, Ki-Jong,Song, Jae-Bong,Pi, Sung-Hee,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and the repair of function. For more than a decade there have been many efforts to develop materials and methods of treatment to promote periodontal tissue regeneration. Recently many efforts are concentrated on the regeneration potential of material used in traditional medicine. Safflower(Carthamus tinctorius L.) seed extract(SSE) have long clinically used in Korea to promote bone formation and prevent osteoporosis. The purpose of this study was to examine the effects of SSE on bone formation in human osteoblastic cell line. Human fetal osteoblastic cell line(hFOB 1.19) was cultured with DMEM and SSE($1{\mu}g/ml$, $10{\mu}g/ml$, $100{\mu}g/ml$, $1mg/ml$) at $34^{\cdot}C$ with 5% $CO_2$ in 100% humidity. The proliferation, differentiation of the cell was evaluated by several experiments. Cell proliferation was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE after 3 and 7 days incubation(p<0.05). Cell spreading assay was significantly increased at $100{\mu}g/ml$ of SSE after 3 days and $1{\mu}g/ml$, $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE after 7 days(p<0.05). Alkaline Phosphatase(ALP) level was significantly increased in $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE(p<0.05). Collagen synthesis was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE(p<0.05). A quantified calcium accumulation was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$ of SSE(p<0.05). ALP and osteocalcin mRNA was expressed in $100{\mu}g/ml$ of SSE by RT-PCR. These results indicate that SSE are capable of increasing osteoblasts mineralization and may play an important role in bone formation.

객체 인식 정확도 개선을 위한 이미지 초해상도 기술

이성진,김태준,이충헌,유석봉,Lee, Sung-Jin,Kim, Tae-Jun,Lee, Chung-Heon,Yoo, Seok Bong 한국정보통신학회 2021 한국정보통신학회논문지 Vol.25 No.6

객체 검출 및 인식 과정은 컴퓨터비전 분야에서 매우 중요한 과업으로써, 관련 연구가 활발하게 진행되고 있다. 그러나 실제 객체 인식 과정에서는 학습된 이미지 데이터와 테스트 이미지 데이터간 해상도 차이로 인하여 인식기의 정확도 성능이 저하되는 문제가 종종 발생한다. 이를 해결하기 위해 본 논문에서는 객체 인식 정확도 향상을 위한 이미지 초해상도 기법을 제안하여 객체 인식 및 초해상도 통합 프레임워크를 설계하고 개발하였다. 세부적으로는 11,231장의 차량 번호판 훈련용 이미지를 웹 크롤링, 인조데이터 생성 등을 통해 자체적으로 구축하고, 이를 활용하여 이미지 좌우 반전에 강인하도록 목적함수를 정의하여 이미지 초해상도 인공 신경망을 훈련시켰다. 제안 방법의 성능을 검증하기 위해 훈련된 이미지 초해상도 및 번호 인식기 1,999장의 테스트 이미지에 실험하였고, 이를 통해 제안한 초해상도 기법이 문자 인식 정확도 개선 효과가 있음을 확인하였다. The object detection and recognition process is a very important task in the field of computer vision, and related research is actively being conducted. However, in the actual object recognition process, the recognition accuracy is often degraded due to the resolution mismatch between the training image data and the test image data. To solve this problem, in this paper, we designed and developed an integrated object recognition and super-resolution framework by proposing an image super-resolution technique to improve object recognition accuracy. In detail, 11,231 license plate training images were built by ourselves through web-crawling and artificial-data-generation, and the image super-resolution artificial neural network was trained by defining an objective function to be robust to the image flip. To verify the performance of the proposed algorithm, we experimented with the trained image super-resolution and recognition on 1,999 test images, and it was confirmed that the proposed super-resolution technique has the effect of improving the accuracy of character recognition.

Effects of Dietary Addition of Wormwood (Artemisia sp.) on the Growth Performance, Nutrients Utilization, and Abdominal Fat Deposition of Broiler Chickens

이성진,송기덕,고영두,김창현,Lee, Sung-Jin,Song, Ki-Duk,Ko, Yung-Du,Kim, Chang-Hyun Korean Association of Organic Agriculture 2010 韓國有機農業學會誌 Vol.18 No.3

This study was carried out to investigate the effects of wormwood (Artemisia sp.) addition on the growth performance, nutrients utilization and abdominal fat deposition of broiler chickens. Two hundred twenty five and two-day old Arboracre strain male commercial broiler chicks were distributed to 5 treatments with wormwood supplementation levels; C(O%), $T_1$ (1%), $T_2$ (3%), $T_3$ (5%), and $T_4$ (10%) and with 3 replications each with 5 birds for five weeks. Body weight gain during the experiment was improved in $T_1$ (1723.0g) compared with that of $T_3$ (1557.7g) and $T_4$ (1450.7g) (P<0.05). Feed intake was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 2653.8g, T1: 2852.0, $T_2$: 2900.3, $T_3$: 2900.7g, T4: 2954.7g). Feed conversion rate (feed/gain) was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 1.55, $T_1$: 1.66, $T_2$: 1.70, $T_3$: 1.86, $T_4$: 2.04). The days reaching to 2.0kg of body weight were expected to be 43.2 days in control, whereas those of group T1 were reduced to 42.6 days by 0.6 day from control. Nutrient utilization and abdominal fat deposition in the experiment were significantly decreased (P<0.05) and small intestine contents in the broilers was significantly increased (P<0.05) as the levels of wormwood addition increased. Therefore, although there was no significant improvement for the performance of broiler chickens with the dietary supplementation of wormwood meal, less than 1% addition of wormwood to broiler diets might have beneficial for human health by reducing the abdominal fat deposition of the broiler chicknens. 본 연구는 국내에서 약용으로 많이 사용되고 있는 쑥을 건조시켜 사료에 첨가할 경우 육계의 성장률, 영양소 이용률, 복강내 지방함량에 미치는 영향을 구명하기 위하여 2일령의 Arbroracre 계통의 육계 숫병아리 225 수를 공시하여 쑥 분말의 첨가를 00/0(대조군, C), 1% ($T_l$), 3%($T_2$), 5%($T_3$), 10%($T_4$) 둥 모두 5개 군으로 나누어 5 주간 3 반복 사양실험하였다. 육계의 최종체중 1% 처리군($T_l$ : 1723.0g)이 대조군(1715.3g), $T_2$(1708.3g), $T_3$(1557.7g, P<0.05), 그리고 $T_4$(l450.7g) 보다 효과가 좋았다. 그러나 사료 섭취량은 쑥 분말 첨가량이 많아질수록 증가하였다(C: 2653.8g, $T_l$: 2852.0, $T_2$: 2900.3, $T_3$: 2900.7g, $T_4$: 2954.7g). 또한 쑥 분말 1% 첨가군($T_l$)에서 2kg 도달일령이 가장 우수하여 대조군 보다 0.6일 빠른 42.6일이었으나 쑥 분말을 3% 이상 처리시에는 오히려 늦어지는 것으로 나타났다. 사료요구량은 쑥분말 첨가가 증가함에 따라 유의적으로 증가하졌지만, 복강내 지방함량은 유의적으로 감소하였다. 비록 체중, 사료요구량, 사료 섭취량 등은 대조구와 비교하여 효과가 없었지만, 복강내 지방함량을 고려할 때, 쑥 분말 첨가 1% 이하로 급여할 경우 인간의 건강에는 효과적일 것으로 판단되었다.

저전력장거리 기술과 임베디드 보드를 이용한 치매 돌봄 스마트 신발 구현

이성진,최준형,서창성,박병권,최병윤,Lee, Sung-Jin,Choi, Jun-Hyeong,Seo, Chang-Sung,Park, Byung-Kwon,Choi, Byeong-Yoon 한국정보통신학회 2020 한국정보통신학회논문지 Vol.24 No.1

본 논문에서는 저전력장거리 기술과 임베디드 보드를 이용한 치매 돌봄 스마트 신발과 응용 소프트웨어를 구현하였다. Cortex-M3 보드와 로라 모듈로 구성된 통신 모듈은 신발 밑창의 홈에 내장 된다. 위치추적 응용 소프트웨어는 임베디드 보드에서 제공하는 신호와 GPS와 로라 망을 이용하여 보호자가 치매 환자의 위치 추적할 수 있다. 외부 환경에서 스마트 신발의 위치 추적 및 데이터 전송 동작이 성공적으로 확인되었다. 이러한 실험을 통해 본 논문에서 개발한 스마트 신발이 치매 환자의 돌봄을 위한 실종을 막는 안전장치로 응용 가능할 것으로 판단된다. In this paper smart shoes for dementia care using embedded boards and Low Power Wide Area technology and their application software are implemented. The communication board composed of Cortex-M3 board and LoRa module is embedded into groove made in outsole of smart shoes. Including the mold, the shoe outsole was manufactured by hand. By using application software and embedded board, caregiver can track the position of dementia patient using GPS and LoRa network. The location tracking and data transmission operations of smart shoes have been successfully verified in the outdoor environment. The smart shoes of this paper are applicable to a safety device to prevent the disappearance of demented patients through results of experiments and if bigdata is collected and analyzed by deep-learning, it may be helpful to analyze the predictive path of dementia patients or the pattern of dementia.

궤도 개량을 위한 도상/노반 평가 시험

이성진,장승엽,이종섭,박형춘,최진수,Lee, Sung Jin,Jang, Seung Yup,Lee, Jong Sub,Park, Hyung Choon,Choi, Jin Soo 한국구조물진단유지관리공학회 2014 한국구조물진단유지관리공학회지 Vol.18 No.3

SKH-1 Hairless Mice에서의 히알루론산 경구 투여를 통한 피부 광노화 개선 효과

이성진,서윤희,윤민규,유희종,최수영,Lee, Sung-jin,Seo, YoonHee,Yun, Min-kyu,Yu, Heui-jong,Choe, Soo-Young 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.6

Photoaging is the main extrinsic aging factor that is induced due to UVB. Many studies have revealed that application of hyaluronic acid to the skin is effective in healing photoaging. However, the effect of hyaluronic acid through oral administration is unclear. The aim of this research was to investigate the effect on skin photoaging after oral administration of hyaluronic acid. During a ten week study, hyaluronic acid was fed to hairless mice, which were illuminated by UV radiation. After ten weeks, wrinkle indicator and histological changes were determined. Compared with the control group, the sample group had a decrease in wrinkle depth, thickness, and number. Especially, the HA 160 mg/kg group had a similar value of wrinkle depth ($19.44{\pm}0.75{\mu}m$), number ($654.00{\pm}98.34$), and thickness ($1.35{\pm}0.08mm$), when compared with the RA (retinoic acid) group ($19.28{\pm}0.95{\mu}m$, $653.57{\pm}83.54$, and $1.34{\pm}0.07mm$ respectively). Also, the treated group showed improved elastosis and decreased collagen degradation resulting from UV irradiation. Thus, we can conclude that hyaluronic acid has a positive effect in improving skin photoaging induced by UV radiation. Hyaluronic acid therefore has the potential to be an ingredient in skin health function foods. 본 연구에서는 HA에 대하여 UVB로 주름을 유도시킨 hairless mice에게 경구 투여를 하였을 때, 주름 개선에 미치는 영향을 관찰하였다. 쥐는 UV를 쪼여 광노화를 진행하였으며, HA는 UVB에 노출시키기 4주 전부터 투여하여 총 14주 동안 투여하였다. 주름 개선 평가는 replica 제작하여 주름의 길이, 깊이, 개수, 두께로 평가하였다. 또한, 피부의 조직학적 평가를 통해 진피층 내 교원섬유와 탄력섬유의 양과 형태를 관찰하였다. 10주 동안의 HA를 급여하였을 때 주름의 깊이, 두께, 개수를 측정한 주름 개선 평가에서 세 항목 모두 개선되는 결과를 보였다. 특히 HA의 160 mg/kg 농도에서는 주름의 깊이는 $19.44{\pm}0.75{\mu}m$, 주름 수는 $654.00{\pm}98.34$, 주름두께는 $1.35{\pm}0.08mm$로 양성 대조군(RA)의 결과(주름깊이; $19.28{\pm}0.95{\mu}m$, 주름 수; $953.57{\pm}83.54$, 주름두께; $1.34{\pm}0.07mm$)와 비슷한 수치를 나타내며, 우수한 피부 광노화 개선효과를 보였다. 하지만, 주름길이의 결과에서는 유의적 차이를 나타내지 않았다. HA의 섭취로 인한 교원섬유 및 탄력섬유 염색을 통한 조직학적 평가에서는 UV에 의해 밀도가 엉성하고 배열이 불규칙적이던 섬유들이 개선된 것을 관찰할 수 있었다. 이상의 결과로 보아 HA를 경구 투여 시 UV로부터 유도된 광노화 억제 및 피부주름 개선에 효능이 있음을 확인하였다.

형방도적산(荊防導赤散)으로 호전된 소양인(少陽人) 말초성 안면신경마비 환자 치험 2례

이성진,조혜원,정해연,임은철,Lee, Sung-Jin,Cho, Hye-Won,Jeong, Hae-Yeon,Lim, Eun-Chul 사상체질의학회 2014 사상체질의학회지 Vol.26 No.4

Objectives We report a series of 2 treatment cases with Hyeongbangdojok-san which is based on Sasang Constitutional Medicine for peripheral facial palsy in Soyangin. Methods We diagnosed these two cases as a Soyangsangpung. And we prescribed Hyeongbangdojok-san for their physical symptoms. The improvement of their peripheral facial palsy were evaluated. Results After the Hyeongbangdojok-san was given, the patient's peripheral facial paralysis and physical symptoms were improved. Conclusions These case-studies showed an efficient result of using Hyeongbangdojok-san in the peripheral facial paralysis of Soyangin.