프로테오믹스를 이용한 당뇨망막병증 환자의 유리체 분석

이성진,이성호,박성희,이성철,권오웅,Sung Jin Lee,Sung Ho Lee,Song Hee Park,Sung Chul Lee,Oh Woong Kwon 대한안과학회 2007 대한안과학회지 Vol.48 No.4

Purpose: This study analyzed protein alterations between the normal vitreous and the vitreous with proliferative diabetic retinopathy by proteomics to find the proteins which may elicit diabetic retinopathy. Methods: Two-dimensional electrophoresis was used to make the protein map. Image analysis between the spots on each gels by a proteomics based approach were used to reveal vitreous protein alterations which may elicit proliferative diabetic retinopathy. MALDI-TOF/ESI-TOF mass spectrometry also was used to identify altered protein spots on the gel. Results: Of the 110 different spots on each gels, 36 different proteins were identified and among them 23 proteins were altered in the vitreous with proliferative diabetic retinopathy compared with normal vitreous. Nineteen proteins including alpha-1-antitrypsin, Ig G and A, and complement C3 and C4 were increased in the vitreous with proliferative diabetic retinopathy and 4 proteins includng pigment epithelium derived factor were decreased compared to the normal vitreous. Conclusions: The authors found that pigment epithelium derived factor may be the key protein that induces the neovascularization in the vitreous with proliferative diabetic retinopathy. Increased levels of Ig G and A and C3 and C4 is thought to be related to the autoimmune inflammation in early diabetic microangiopathy. Furthermore, proteins such as alpha-1-antitrypsin may contribute to protective functions of the ischemic retinal cells.

혀 기저부에 발생한 신경초종 1례

이성진,진성민,이창희,이선욱,Lee, Sung-Jin,Jin, Sung-Min,Lee, Chang-Hee,Lee, Seon-Uk 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.2

Schwannoma are benign, solitary and encapsulated tumors originating from the Schwann cells of the nerve sheath. About 25% to 40% of all schwannomas are found in the head and neck and the acoustic nerve is most frequently involved, but schwannomas of the tongue is rare. When they do occur, treatment is simple. However, diagnosis is invariably delayed because of the vagueness of symptoms. Recently, authors experienced a case of schwannoma occurred in the base of tongue and the tumor was successfully removed through intraoral approach. So we report this case with literature review.

고려시대 왕실호위제도의 사적 고찰

이성진,김의영,이종환,Lee, Sung-Jin,Kim, Eui-Young,Lee, Jong-Hwan 한국경호경비학회 2007 시큐리티연구 Vol.- No.14

고려시대의 왕실 호위라 함은 오늘날로 보면 국가원수에 대한 경호에 해당한다. 고려시대의 독특한 정치제도가 완성되기까지는 신라시대나 태봉국의 제도를 답습하여 왕의 신변을 중심으로 경호가 실행되었다. 고려의 중앙군은 2군과 6위라는 8개의 부대로 편성되었다. 2군은 6위보다 위였으며 이는 응양군(鷹揚軍)과 용호군(龍虎軍)으로서 이를 근장(近仗)이라고 불렀다. 이를 오늘날의 공경호와 관련을 지어보면 근접경호에 해당된다. 고려 귀족 사회의 안정기에 귀족문화의 전성기를 누렸으나 그 뒤로 귀족분열과 상극대립으로 중앙통제력이 약화되는 가운데 무신란이 일어나고 무신들이 집권함으로서 왕의 신변은 안정되지 못하였다. 최씨 무인집권시대에 이르러 무인집권의 안전을 위하여 도방을 설치했고 최우 시대에는 그의 문객들을 모아 사병들뿐만 아니라 정방, 서방, 등의 문신을 거느려 인사행정을 담당케 했다. 몽고에 항쟁하던 시대에는 무신통치의 군사적 기반이었던 삼별초를 중심으로 항쟁했다. 최씨 정권시대의 그들 나름의 국가관과 국가 호위의 정신을 알 수 있다. The Guard over the royal household in the "Goryeo" era was the same as if was over the President or Ruler of a nation today. In those days, a king represented a nation and any threat to the safety of a king could bring the destruction of a nation and the dispersion of the people. by reviewing the change of the 2-Gun 6-Wi system of the era, it can be, summed up as follow, Ther will be suggestions. The Guard might focus on a king's personal safety in the wake of the system of the Silla and Taebong dynasties until the establishment of the Goryeo Dynasty's unique political system. "Goryeo" rebuilt the royal palace in Gyeonyeong-gun to take the shape of unified country after its accomplishment of unification of the late three countries, Then it was afraid of the rebellion and uprising of local powerful clans, The country put them under control and organized the local army with them in the era of Kings, Seongjong, through the kings, Seongjong and Gwangjong. The army system of "Goryeo" consisted of 2-Gun and 6-Wi, and 2-Gun placed above the 6-Wi played the role of the Royal guards, and among the organizations a certain army under the specific name of "Gyeonyong-gun" guarded the kings in the nearest position. An aristocratic culture enjoyed its golden age in the period of stability of the aristocracy of "Goryeo", but afterward in the confusion of the aristocratic disruption and incompatible confrontation the country lost its control, and faced military rebellions by treating civil officials well and ill-treating military officials The safety of kings become unstable with the grasping political power by the military officials, and "Dobang" was established in the era of Choi's family to grasp political power. In the era of Choi Woo, he gathered his men and organized his familys army with them and managed the personnel administration with the civil officials of "Jeongbang and Seobang under his command. Such a fact shows the similarity to today's task of guarding. Considering the facts that "Sambyeolcho, the military ground of the military-men-rule, was at the center of the struggling against Mongolia and that even after the fall of the military regime, they rebelled and fought against Mongolia to the end, we came to know that the nationalism in the era of the military era was great. In the transition of external situations from "Myeong" to "Won"(Chinese dynasties), the conflict between the old "Won"-friendly power and the new "Myeong"-friendly power caused the weakness of the power to guard the royal household, and "Goryeo" at last gave way to the newly rising "Joseon" led by Lee, Seong Gye who won the people's confidence.

함정의 경향과 전망

이성진,Lee, Seong-Jin 한국방위산업진흥회 1989 國防과 技術 Vol.- No.119

객체 인식 정확도 개선을 위한 이미지 초해상도 기술

이성진,김태준,이충헌,유석봉,Lee, Sung-Jin,Kim, Tae-Jun,Lee, Chung-Heon,Yoo, Seok Bong 한국정보통신학회 2021 한국정보통신학회논문지 Vol.25 No.6

객체 검출 및 인식 과정은 컴퓨터비전 분야에서 매우 중요한 과업으로써, 관련 연구가 활발하게 진행되고 있다. 그러나 실제 객체 인식 과정에서는 학습된 이미지 데이터와 테스트 이미지 데이터간 해상도 차이로 인하여 인식기의 정확도 성능이 저하되는 문제가 종종 발생한다. 이를 해결하기 위해 본 논문에서는 객체 인식 정확도 향상을 위한 이미지 초해상도 기법을 제안하여 객체 인식 및 초해상도 통합 프레임워크를 설계하고 개발하였다. 세부적으로는 11,231장의 차량 번호판 훈련용 이미지를 웹 크롤링, 인조데이터 생성 등을 통해 자체적으로 구축하고, 이를 활용하여 이미지 좌우 반전에 강인하도록 목적함수를 정의하여 이미지 초해상도 인공 신경망을 훈련시켰다. 제안 방법의 성능을 검증하기 위해 훈련된 이미지 초해상도 및 번호 인식기 1,999장의 테스트 이미지에 실험하였고, 이를 통해 제안한 초해상도 기법이 문자 인식 정확도 개선 효과가 있음을 확인하였다. The object detection and recognition process is a very important task in the field of computer vision, and related research is actively being conducted. However, in the actual object recognition process, the recognition accuracy is often degraded due to the resolution mismatch between the training image data and the test image data. To solve this problem, in this paper, we designed and developed an integrated object recognition and super-resolution framework by proposing an image super-resolution technique to improve object recognition accuracy. In detail, 11,231 license plate training images were built by ourselves through web-crawling and artificial-data-generation, and the image super-resolution artificial neural network was trained by defining an objective function to be robust to the image flip. To verify the performance of the proposed algorithm, we experimented with the trained image super-resolution and recognition on 1,999 test images, and it was confirmed that the proposed super-resolution technique has the effect of improving the accuracy of character recognition.

사상체질집단의 ADPRT gene 3'UTR region의 단일염기다형성 연구

이성진,송일병,이수경,Lee, Sung-Jin,Song, Il-Byung,Lee, Su-Kyung 사상체질의학회 2002 사상체질의학회지 Vol.14 No.2

Sasang Constitutional Medicine is based on the diversity of human being and medically developed the variation of response to diseases and medicines. The diversity is categorized as four groups Taeyangin, Taeumin, Soyangin, Soeumin according to morphology, physiology, pathology, and pharmacology. The phenotypes of Sasang constitutions represent that constitutions may be possessed of the different genetic backgrounds. To clarify the genetic difference among the Sasang constitutions, we performed a genetic analysis with the 3'-UTR polymorphism of ADPRT (rs=8679) as a pooled DNA sequencing method. ADPRT modulates various nuclear proteins by poly(ADP-ribosy)lation and is involved in the regulation of various cellular processes such as differentiation, proliferation, and tumor transformation. This gene is also involved in the recovery of cell from DNA damage and the brain infarction. The allele frequencies of [T/C] polymorphism of ADPRT of Soeumin and Soyangin groups were (T: 0.94/C: 0.06) and that of Taeumin and Taeyangin groups were (T: l.00/C: 0.00). The allele frequency was not showed the difference between constitution groups. This result represented that the [T/C] polymorphism of ADPRT 3' UTR region was not suitable to classify the constitutions. However, this study is the first trial of Sasang classification according to genetic polymorphism and further analysis will be necessarily to classify the genetic difference of Sasang constitution.

무수은 제논 EEFL의 전기적 특성

이성진,김남군,이종찬,박노준,박대희,Lee, Seong-Jin,Kim, Nam-Goon,Lee, Jong-Chan,Park, Noh-Joon,Park, Dae-Hee 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.7

This paper had mentioned about CCP light source application for increasing the efficiency of Xe lamp the mercury-free lamp. In order to increase the efficiency of Xe EEFL, we designed and manufactured the lamp used by mixture gas of Xe, Ne and He. Also, we have analyzed the electrical and optical properties with the firing voltage, sustain voltage, paschen's curve, wall charge, and capacitance. As a result, the firing voltage decreased by increasing the ration of mixture gas. and, It is owing to include the gas with high ionization energy. The firing voltage decreased in condition happening the penning effect, Because the ion of metastable state created from penning effect, Which can encourage the ionization phenomena. Also, the wavelength of 467.12 is increase. because of the energy transition in the wavelength of 147 nm. therefore, we can know about the affection of phosphor with UV emission properties. Through an experiment, Xe 100 % and Xe 75 % confirmed same spectrum properties by each mixture gas ratio. In the case of Xe 50 %, spectrum properties appeared Xe discharge and Ne-He discharge. That analyzed an electrical and optical properties. Therefore, confirmed that is excellent because properties of firing voltage, wall charge, capacitance in Xe 50 %, Ne : He = 9 : 1. We offered parameter in inverter manufacture and lamp manufacture by electrical and optical properties.

플레이트 열교환기에 관한 연구

이성진,고득용,염한길,홍용주,Lee, Seong-Jin,Go, Deuk-Yong,Yeom, Han-Gil,Hong, Yong-Ju 재료연구소 1995 機械와 材料 Vol.7 No.4

식품용 소형 진공 동결 건조기의 개발(I)

이성진,김욱중,Lee, Seong-Jin,Kim, Uk-Jung 한국기계연구원 1992 硏究論文集 Vol.22 No.-

A basic study on the batch type freeze dryer has been carried out. The operating principles, merits and demerits of the freeze dryer were described. And the kinds of major components and their roles were also invesigated. As a fundamental study, using the Differential Scanning Calorimeter(DSC), the determination of unfrozen water in the specimens and invesigation of effects of cooling rate on the freeze drying were performed. To provide a guidline of basic design for a freeze dryer, a parametric study about the drying conditions was carried out.

적목현상 특징을 이용한 적목현상 보정 알고리즘 및 하드웨어 구현

이성진,장원우,최원태,김석찬,강봉순,Lee, Song-Jin,Jang, Won-Woo,Choi, Won-Tae,Kim, Suk-Chan,Kang, Bong-Soon 한국융합신호처리학회 2009 융합신호처리학회 논문지 (JISPS) Vol.10 No.3

In this paper, we proposed an algorithm of redeye correction. For naturally redeye correction, we assumed positions of the redeye at an image which produced redeye, and we estimated rate of the redeye to apply the appropriate redeye correction suitably. We extract and label pixels those are possible of generating redeye using red, skin and reflected light color. The each labeled group is decided by rates of length and width, dimension, density, the color of white of the eye and reflected light color of groups for the redeye group. We corrected positions of redeye using blurring effect, naturally. In the case of designing the proposed algorithm, we designed the redeye correction hardware using the minimum of memories for efficiency of hardware. 본 논문은 적목현상 보정을 위한 알고리즘에 관한 것이다. 자연스러운 보정을 위해 적목현상이 발생한 이미지에서 적목현상이 발생한 위치를 추정하고 적목현상의 정도를 판단하여 적절한 보정을 적응적으로 적용할 수 있도록 하였다. 붉은 색, 피부색, 반사광색을 이용하여 적목현상이 발생했을 가능성이 있는 픽셀을 추출하고 픽셀들을 그룹화하여 레이블링 하였다. 레이블링 된 각 그룹들 중에서 그룹의 가로와 세로의 비율, 크기, 밀도, 흰자위색과 피부색등을 이용하여 어떠한 그룹이 적목현상이 발생한 그룹인지를 판단하였다. 적목현상이 발생한 위치는 블러링 효과를 만들어 자연스럽게 보정하였다. 제안된 알고리즘을 하드웨어로의 설계 할 경우 하드웨어 자원의 효율성을 극대화하기 위해 알고리즘을 최소한의 메모리를 사용하여 개발하였다.