프로테오믹스를 이용한 당뇨망막병증 환자의 유리체 분석

이성진,이성호,박성희,이성철,권오웅,Sung Jin Lee,Sung Ho Lee,Song Hee Park,Sung Chul Lee,Oh Woong Kwon 대한안과학회 2007 대한안과학회지 Vol.48 No.4

Purpose: This study analyzed protein alterations between the normal vitreous and the vitreous with proliferative diabetic retinopathy by proteomics to find the proteins which may elicit diabetic retinopathy. Methods: Two-dimensional electrophoresis was used to make the protein map. Image analysis between the spots on each gels by a proteomics based approach were used to reveal vitreous protein alterations which may elicit proliferative diabetic retinopathy. MALDI-TOF/ESI-TOF mass spectrometry also was used to identify altered protein spots on the gel. Results: Of the 110 different spots on each gels, 36 different proteins were identified and among them 23 proteins were altered in the vitreous with proliferative diabetic retinopathy compared with normal vitreous. Nineteen proteins including alpha-1-antitrypsin, Ig G and A, and complement C3 and C4 were increased in the vitreous with proliferative diabetic retinopathy and 4 proteins includng pigment epithelium derived factor were decreased compared to the normal vitreous. Conclusions: The authors found that pigment epithelium derived factor may be the key protein that induces the neovascularization in the vitreous with proliferative diabetic retinopathy. Increased levels of Ig G and A and C3 and C4 is thought to be related to the autoimmune inflammation in early diabetic microangiopathy. Furthermore, proteins such as alpha-1-antitrypsin may contribute to protective functions of the ischemic retinal cells.

혀 기저부에 발생한 신경초종 1례

이성진,진성민,이창희,이선욱,Lee, Sung-Jin,Jin, Sung-Min,Lee, Chang-Hee,Lee, Seon-Uk 대한후두음성언어의학회 2009 대한후두음성언어의학회지 Vol.20 No.2

Schwannoma are benign, solitary and encapsulated tumors originating from the Schwann cells of the nerve sheath. About 25% to 40% of all schwannomas are found in the head and neck and the acoustic nerve is most frequently involved, but schwannomas of the tongue is rare. When they do occur, treatment is simple. However, diagnosis is invariably delayed because of the vagueness of symptoms. Recently, authors experienced a case of schwannoma occurred in the base of tongue and the tumor was successfully removed through intraoral approach. So we report this case with literature review.

고려시대 왕실호위제도의 사적 고찰

이성진,김의영,이종환,Lee, Sung-Jin,Kim, Eui-Young,Lee, Jong-Hwan 한국경호경비학회 2007 시큐리티연구 Vol.- No.14

고려시대의 왕실 호위라 함은 오늘날로 보면 국가원수에 대한 경호에 해당한다. 고려시대의 독특한 정치제도가 완성되기까지는 신라시대나 태봉국의 제도를 답습하여 왕의 신변을 중심으로 경호가 실행되었다. 고려의 중앙군은 2군과 6위라는 8개의 부대로 편성되었다. 2군은 6위보다 위였으며 이는 응양군(鷹揚軍)과 용호군(龍虎軍)으로서 이를 근장(近仗)이라고 불렀다. 이를 오늘날의 공경호와 관련을 지어보면 근접경호에 해당된다. 고려 귀족 사회의 안정기에 귀족문화의 전성기를 누렸으나 그 뒤로 귀족분열과 상극대립으로 중앙통제력이 약화되는 가운데 무신란이 일어나고 무신들이 집권함으로서 왕의 신변은 안정되지 못하였다. 최씨 무인집권시대에 이르러 무인집권의 안전을 위하여 도방을 설치했고 최우 시대에는 그의 문객들을 모아 사병들뿐만 아니라 정방, 서방, 등의 문신을 거느려 인사행정을 담당케 했다. 몽고에 항쟁하던 시대에는 무신통치의 군사적 기반이었던 삼별초를 중심으로 항쟁했다. 최씨 정권시대의 그들 나름의 국가관과 국가 호위의 정신을 알 수 있다. The Guard over the royal household in the "Goryeo" era was the same as if was over the President or Ruler of a nation today. In those days, a king represented a nation and any threat to the safety of a king could bring the destruction of a nation and the dispersion of the people. by reviewing the change of the 2-Gun 6-Wi system of the era, it can be, summed up as follow, Ther will be suggestions. The Guard might focus on a king's personal safety in the wake of the system of the Silla and Taebong dynasties until the establishment of the Goryeo Dynasty's unique political system. "Goryeo" rebuilt the royal palace in Gyeonyeong-gun to take the shape of unified country after its accomplishment of unification of the late three countries, Then it was afraid of the rebellion and uprising of local powerful clans, The country put them under control and organized the local army with them in the era of Kings, Seongjong, through the kings, Seongjong and Gwangjong. The army system of "Goryeo" consisted of 2-Gun and 6-Wi, and 2-Gun placed above the 6-Wi played the role of the Royal guards, and among the organizations a certain army under the specific name of "Gyeonyong-gun" guarded the kings in the nearest position. An aristocratic culture enjoyed its golden age in the period of stability of the aristocracy of "Goryeo", but afterward in the confusion of the aristocratic disruption and incompatible confrontation the country lost its control, and faced military rebellions by treating civil officials well and ill-treating military officials The safety of kings become unstable with the grasping political power by the military officials, and "Dobang" was established in the era of Choi's family to grasp political power. In the era of Choi Woo, he gathered his men and organized his familys army with them and managed the personnel administration with the civil officials of "Jeongbang and Seobang under his command. Such a fact shows the similarity to today's task of guarding. Considering the facts that "Sambyeolcho, the military ground of the military-men-rule, was at the center of the struggling against Mongolia and that even after the fall of the military regime, they rebelled and fought against Mongolia to the end, we came to know that the nationalism in the era of the military era was great. In the transition of external situations from "Myeong" to "Won"(Chinese dynasties), the conflict between the old "Won"-friendly power and the new "Myeong"-friendly power caused the weakness of the power to guard the royal household, and "Goryeo" at last gave way to the newly rising "Joseon" led by Lee, Seong Gye who won the people's confidence.

홍화인 추출물이 골 형성에 미치는 영향에 관한 실험실적 연구

이성진,최호철,선기종,송제봉,피성희,유형근,신형식,Lee, Seong-jin,Choi, Ho-Chul,Sun, Ki-Jong,Song, Jae-Bong,Pi, Sung-Hee,You, Hyung-Keun,Shin, Hyung-Shik 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.2

The ultimate goal of periodontal therapy is the regeneration of periodontal tissue and the repair of function. For more than a decade there have been many efforts to develop materials and methods of treatment to promote periodontal tissue regeneration. Recently many efforts are concentrated on the regeneration potential of material used in traditional medicine. Safflower(Carthamus tinctorius L.) seed extract(SSE) have long clinically used in Korea to promote bone formation and prevent osteoporosis. The purpose of this study was to examine the effects of SSE on bone formation in human osteoblastic cell line. Human fetal osteoblastic cell line(hFOB 1.19) was cultured with DMEM and SSE($1{\mu}g/ml$, $10{\mu}g/ml$, $100{\mu}g/ml$, $1mg/ml$) at $34^{\cdot}C$ with 5% $CO_2$ in 100% humidity. The proliferation, differentiation of the cell was evaluated by several experiments. Cell proliferation was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE after 3 and 7 days incubation(p<0.05). Cell spreading assay was significantly increased at $100{\mu}g/ml$ of SSE after 3 days and $1{\mu}g/ml$, $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE after 7 days(p<0.05). Alkaline Phosphatase(ALP) level was significantly increased in $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE(p<0.05). Collagen synthesis was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$, 1mg/ml of SSE(p<0.05). A quantified calcium accumulation was significantly increased at $10{\mu}g/ml$, $100{\mu}g/ml$ of SSE(p<0.05). ALP and osteocalcin mRNA was expressed in $100{\mu}g/ml$ of SSE by RT-PCR. These results indicate that SSE are capable of increasing osteoblasts mineralization and may play an important role in bone formation.

유리체절제술의 학습곡선

이성진,박수은,Sung Jin Lee,Su Eun Park 대한안과학회 2007 대한안과학회지 Vol.48 No.7

Purpose: To determine the learning curve of surgeons who perform vitrectomy by studying the results of the first 500 vitrectomy cases that were performed after a fellowship training course for a retina surgeon. Methods: The medical records of the first 500 vitrectomy cases performed by a retina surgeon from February 2001 were reviewed. We included the first operation of each eye and excluded partial vitrectomy and ocular laceration cases. We defined failure as reoperation cases within 3 months and cases with serious visual complication. Results: There were 261 eyes (52.2%) from male patients, and 239 eyes (48.7%) from female patients; the average age was 59.7 years old. The causative diseases were, in order of frequency, proliferative diabetic retinopathy, retinal detachment, and branch retinal vein occlusion. The final visual outcomes showed improvement of more than 2 lines in 274 eyes (54.8%), and a decrease of more than 2 lines in 50 eyes (10.0%). Failure was the outcome in 37 eyes (7.4%) and was more frequent in the first 2 years of surgeries; the causes of failure were, in order of frequency, retinal detachment, vitreous hemorrhage, and neovascular glaucoma. Visual acuity in the first 2 years, during which failure was more frequent, was not different from that in the last 3 years. Conclusions: To achieve consistently stable results in vitrectomy, a newly trained retina surgeon needs about 150 cases of vitrectomy or 2 years of experience.

지루성 피부염의 한의학적 문헌 고찰

이성진,홍철희,정미림,Lee, Sung-Jin,Hong, Chul-Hee,Jung, Mi-Rim 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.2

Objectives : The aim of this study is to analyze research of Korean medicine for the treatment of seborrheic dermatitis. Methods : We searched domestic journals with the title 'seborrheic, dermatitis, 脂漏, 面遊風, 白屑風, 紐扣風'. We searched The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology, NDSL, RISS, KISS, The National Assembly Library and OASIS. Results : We selected 15 papers; 11 clinical trials, 4 systematic reviews. In clinical trial all studies showed positive effect, but less example used in the studies. Conclusions : Positive effect of Korean Medicine on seborrheic dermatitis is expected. But we find several limits in many papers, so we conclude that well-designed researches are needed.

전해질 첨가제에 따른 graphite 음극의 SEI분석 및 전기 화학적 특성 고찰

이성진,차은희,임수아,Lee, Sung Jin,Cha, Eun Hee,Lim, Soo A 한국전기화학회 2016 한국전기화학회지 Vol.19 No.3

Lithium ion battery with high energy density is expanding its application area to electric automobile and electricity storage field beyond existing portable electric devices. Such expansion of an application field is demanding higher characteristic and stable long life characteristic of an anode material, the natural graphite that became commercialized in lithium ion battery. This thesis produced cathode by using natural graphite anode material, analyzed creation of the cathode SEI film created due to initial reaction by using electrolyte additives, VC (vinylene carbonate), VEC (vinyl ethylene carbonate), and FEC (fluoroethylene carbonate), and considered correlation with the accompanying electrochemical transformation. This study compared and analyzed the SEI film variation of natural graphite cathode according to the electrolyte additive with SEI that is formed at the time of initial filling and cathode of $60^{\circ}C$ life characteristic. At the time of initial filling, the profile showed changes due to the SEI formation, and SEI was formed in No-Additive in approximately 0.9 V through EVS, but for VC, VEC, and FEC, the formation reaction was created above 1 V. In $60^{\circ}C$ lifespan characteristic evaluation, the initial efficiency was highest in No-Additive and showed high contents percentage, but when cycle was progressed, the capacity maintenance rate decreased more than VC and FEC as the capacity and efficiency at the time of filling decreased, and VEC showed lowest performance in efficiency and capacity maintenance rate. Changes of SEI could not be verified through SEM, but it was identified that as the cycle of SEI ingredients was progressed through FT-IR, ingredients of Alkyl carbonate ($RCO_2Li$) affiliation of the $2850-2900cm^{-1}$ was maintained more solidly and the resistance increased as cycle was progressed through EIS, and specially, it was identified that the resistance due to No-Additive and SEI of VEC became very significant. Continuous loss of additives was verified through GC-MS, and the loss of additives from partial decomposition and remodeling of SEI formed the non-uniform surface of SEI and is judged to be the increase of resistance.

궤도 개량을 위한 도상/노반 평가 시험

이성진,장승엽,이종섭,박형춘,최진수,Lee, Sung Jin,Jang, Seung Yup,Lee, Jong Sub,Park, Hyung Choon,Choi, Jin Soo 한국구조물진단유지관리공학회 2014 한국구조물진단유지관리공학회지 Vol.18 No.3

무수은 제논 EEFL의 전기적 특성

이성진,김남군,이종찬,박노준,박대희,Lee, Seong-Jin,Kim, Nam-Goon,Lee, Jong-Chan,Park, Noh-Joon,Park, Dae-Hee 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.7

This paper had mentioned about CCP light source application for increasing the efficiency of Xe lamp the mercury-free lamp. In order to increase the efficiency of Xe EEFL, we designed and manufactured the lamp used by mixture gas of Xe, Ne and He. Also, we have analyzed the electrical and optical properties with the firing voltage, sustain voltage, paschen's curve, wall charge, and capacitance. As a result, the firing voltage decreased by increasing the ration of mixture gas. and, It is owing to include the gas with high ionization energy. The firing voltage decreased in condition happening the penning effect, Because the ion of metastable state created from penning effect, Which can encourage the ionization phenomena. Also, the wavelength of 467.12 is increase. because of the energy transition in the wavelength of 147 nm. therefore, we can know about the affection of phosphor with UV emission properties. Through an experiment, Xe 100 % and Xe 75 % confirmed same spectrum properties by each mixture gas ratio. In the case of Xe 50 %, spectrum properties appeared Xe discharge and Ne-He discharge. That analyzed an electrical and optical properties. Therefore, confirmed that is excellent because properties of firing voltage, wall charge, capacitance in Xe 50 %, Ne : He = 9 : 1. We offered parameter in inverter manufacture and lamp manufacture by electrical and optical properties.

Effects of Dietary Addition of Wormwood (Artemisia sp.) on the Growth Performance, Nutrients Utilization, and Abdominal Fat Deposition of Broiler Chickens

이성진,송기덕,고영두,김창현,Lee, Sung-Jin,Song, Ki-Duk,Ko, Yung-Du,Kim, Chang-Hyun Korean Association of Organic Agriculture 2010 한국유기농업학회지 Vol.18 No.3

This study was carried out to investigate the effects of wormwood (Artemisia sp.) addition on the growth performance, nutrients utilization and abdominal fat deposition of broiler chickens. Two hundred twenty five and two-day old Arboracre strain male commercial broiler chicks were distributed to 5 treatments with wormwood supplementation levels; C(O%), $T_1$ (1%), $T_2$ (3%), $T_3$ (5%), and $T_4$ (10%) and with 3 replications each with 5 birds for five weeks. Body weight gain during the experiment was improved in $T_1$ (1723.0g) compared with that of $T_3$ (1557.7g) and $T_4$ (1450.7g) (P<0.05). Feed intake was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 2653.8g, T1: 2852.0, $T_2$: 2900.3, $T_3$: 2900.7g, T4: 2954.7g). Feed conversion rate (feed/gain) was significantly (P<0.05) increased as the levels of wormwood addition increased (C: 1.55, $T_1$: 1.66, $T_2$: 1.70, $T_3$: 1.86, $T_4$: 2.04). The days reaching to 2.0kg of body weight were expected to be 43.2 days in control, whereas those of group T1 were reduced to 42.6 days by 0.6 day from control. Nutrient utilization and abdominal fat deposition in the experiment were significantly decreased (P<0.05) and small intestine contents in the broilers was significantly increased (P<0.05) as the levels of wormwood addition increased. Therefore, although there was no significant improvement for the performance of broiler chickens with the dietary supplementation of wormwood meal, less than 1% addition of wormwood to broiler diets might have beneficial for human health by reducing the abdominal fat deposition of the broiler chicknens.