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신경병증성 통증 쥐 모델에서 전신적으로 투여한 Ketamine의 선행진통 효과
이보령,김진윤,박선규,구길회,우영철,정용훈,백종화,박정원,이인구 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.2-3
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has been used for the treatment of neuropathic pain. But the preemptive analgesic effect of ketamine in neuropathic pain is not widely known. The purpose of this study was to evaluate the preemptive effect of systemic ketamine in neuropathic pain rat model. Eighteen male rats were divided into ketamine (n=9) and control (n=9) group. The rats were injected with ketamine (5% ketamine 20 mg/kg, intraperitoneal) at 30 min before operation in ketamine group but normal saline in control group. Neuropathic pain model was made by L5 spinal nerve ligation. The spontaneous pain behaviors (weight bearing, licking, limping, motor weakness, foot deformity) and foot withdrawal response frequency (RF) by von Frey filament (VFF, 0.4-2.0-10.0-15.0 g) were measured at pre and post operative 3, 5, 7, 14, 21 and 28th day (POD3-28). There was no difference in spontaneous pain behaviors between two groups. RF with VFF 0.4 and 2.0 g increased from POD3 to POD28 in both groups (p<0.05). RF with VFF 10.0 g increased from POD21 in ketamine group and from POD3 in control group (p<0.05). RF with VFF 15.0 g increased from POD21 in ketamine group and from POD5 in control group (p<0.05). Ketamine group showed lower RF than control group at POD3 and POD7 with VFF 15.0 g (p<0.05). In conclusion systemic injection of high dose ketamine for preemptive analgesia in neuropathic pain rat model delayed the onset of mechanical hyperalgesia with VFF 10.0 and 15.0 g for 3 weeks, but did not prevent the development of neuropathic pain.
이보령,김동현,김진윤 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.2
This study was conducted to evaluate the reliability of the blood pressure measurements using the newly developed wrist-type electronic sphygmomanometer (SE-5000, Sein Electronicsco, Korea). This electronic sphygmomanometer is a compact apparatus measuring the blood pressure by an oscillometric method. The blood pressure of 50 patients was measured 3 times at 10-minute interval. In standard auscultatory method, two trained personnel independently took blood pressure. Then blood pressure was taken by two personnels at once with a double stethoscope on the right upper arm and by the wrist type electronic sphygmomanometer on left wrist simultaneously. It was revealed that a correlation coefficient between the systolic blood pressures by the two methods was 0.95 and that of between the diastolic blood pressures was 0.89. It was proved through this study that the newly developed wrist- type electronic sphygmomanometer be on excellent apparatus for measuring blood pressure.