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장규만(Kyu Man Jang),하기수(Ki Soo Ha),문현창(Hyun Chang Moon),이문철(Moon Chul Lee),유병희(Byung Hee Yu),이홍순(Hong Soon Lee),문성수(Seong Soo Moon) 대한내과학회 1988 대한내과학회지 Vol.35 No.6
N/A Plasma atrial natriuretic peptide (ANP) has been known to be a kind of peptide hormone and to have actions of natriuresis, diuresis and vasodilatation. It has been suggested that plasma ANP may be secreted from the cardiac atrium in response to extracellular fluid volume expansion to maintain blood volume homeostasis, and its level may be raised in volume overloaded conditions, such as congestive heart failure, chronic renal failure and the syndrome of inappropriate antidiuretic hormone secretion. We investigated the effect of fluid removal by sequential ultrafiltration and hemodialysis on circulating plasma ANP in 14 volume overloaded patients with chronic renal failure. The results were as follows: 1) The mean dry weight of patients was 58.3±0.4 kg and the predialytic weight gain was 3.4±0.9 kg. The amount of fluid removal by sequential ultrafilt-ration was 1176±31.7 ml (about 2% of predialytic body weight) and postdialytic weight loss was 3.1±0.3 kg. Systolic and diastolic blood pressures were not significantly changed during sequential ultrafiltration and hemodialysis, Plasma osmolality, BUN and K+ levels were not significantly changed after ultrafiltration but were significantly decreased after hemodialysis. 2) Plasma ANP levels were raised in all patients (mean±SE 205.3±30.7pg/ml, n=l4) compared with healthy contro1s (40.9±4.4 pg/ml, n=16), but showed considerable interpatient variability. 3) Plasma ANP levels fell with fluid removal during ultrafiltration (123.4±4.2 pg/ml, p<0.025) and again as fluid was removed during hemodialysis (88.7±3.1 pg/ml, p<0.05). 4) There was no significant correlation between predialytic weight gain and plasma ANP levels, and between postdialytic weight loss and plasma ANP levels. In conclusion, this study showed that the plasma ANP level was raised as body fluid volume increased in patients with chronic renal failure and fell with fluid removal after dialysis. These findings suggest that changes in body fluid volume play an important role in the regulation of ANP secretion.
강재압축재의 방폭성능에 대한 중력하중효과의 해석적 연구
이경구(Kyung Koo Lee),이문창(Moon Chang Lee) 한국강구조학회 2015 韓國鋼構造學會 論文集 Vol.27 No.3
Equivalent Single-Degree-of-Freedom(SDOF) analysis, most used for blast-resistant design, does not consider the effects of gravity load on the performance evaluation of blast resistance of structural members. However, since there exists gravity load on columns and walls of structures, the blast resistance of structural members should be evaluated considering gravity load on them. In this paper, an approach to reflect the gravity load effects on the equivalent SDOF analysis for dynamic blast response of structural members is proposed. For this purpose, the parametric studies using finite element analysis were performed by varying maximum blast load, blast load duration, and gravity load with constant the resistance and natural period of a structural member. The finite element analysis results were compared with the equivalent SDOF analysis results and the blast response of the structure member was estimated by conducting finite element analyses for various gravity loads. Finally, a graphical solution for ductility of a structural member with the variables of blast load, gravity load and structural member properties was developed. The blast response of structural members under gravity load could be estimated reasonably and easily by using this graphical solution.