http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Flurazepam이 가토 혈중 주정농도에 미치는 영향에 관한 실험적 연구
이기연 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.4
Flurazepam is one of several 1,4-benzodiazepine derivatives widely used in clinical practice. Chemically, it is 7-chloro-1-(2-diethylaminoethyl)-5-(o-flurophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one dihydrochloride. The sedative, anticonvulsant, and muscle relaxant effects of flurazepam on experimental animals resemble those of other benzodiazepines. But, it is used as a safe and potent hypnotic rather than as an anti anxiety agent. Investigators suggested that any new psycho-tropic drug should be tested for their interaction with alcohol, because it might precipitate risk situation in cases of consuming alcohol concurrently. In view of these facts, the author conducted an animal experiment to investigate the effects of flurazepam on blood alcohol level in rabbits. Material and method 1. The experimental work was done on mature rabbits of both sexes, weighing about 2kg. 2. The experimental animals were divided into two groups: the control and the experimental group. 3. The control group was given alcohol alone. 4. The experimental group was divided into 4 subgroups: a) Alcohol plus flurazepam, 15mg/kg of body weight daily for 5 days. b) Alcohol plus flurazepam, 15mg/kg of body weight daily for 10 days. c) Alcohol plus flurazepam, 30mg/kg of body weight daily for 5 days. d) Alcohol plus flurazepam, 30mg/kg of body weight daily for 10 days. 5. Flurazepam was given orally in a single daily dose at a fixed time. The last dose was given one hour and a half before alcohol administration. 6. In all groups, 20% ethanol solution was slowly given in a dose of 5.0ml/kg of body weight for 5 minutes by intravenous route. 7. All of the blood specimens were obtained by cardiac puncture at both 15 and 45 minutes after alcohol administration. 8. The blood alcohol level was determined by Cavett's method. Results 1. Alcohol plus flurazepam, 15mg/kg of body weight daily for 5 days. Flurazepam did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. )respectively, p>0.1) 2. Alcohol plus flurazepam, 15mg/kg of body weight daily for 10 days. In this group, flurazepam elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. (respectively, p<0.05) 3. Alcohol plus flurazepam, 30mg/kg of body weight daily for 5 days. In this group, there was also no significant change in the blood level at both 15 and 45 minutes after alcohol administration. (respectively, p>0.1) 4. Alcohol plus flurazepam, 30mg/kg of body weight daily for 10 days. In this group, flurazepam elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. (respectively, p<0.01) Conclusion 1. Flurazepam, when administered orally in a dose of 15mg/kg of body weight daily for 5 days did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. But, flurazepam, when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. 2. Flurazepam when administered orally in a dose of 30mg/kg of body weight daily for 5 days did not change the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration. But, flurazepam, when administered orally in the same dose daily for 10 days, elevated the blood alcohol level significantly at both 15 and 45 minutes after alcohol administration.
자색옥수수 포엽 및 속대 추출물을 첨가한 안토시아닌 함유 액상차의 특성
이기연,박아름,이재희,배선화,김태희,김다솜,김재은,김희연,최성진,함진관 한국산업식품공학회 2020 학술대회 및 심포지엄 Vol.2020 No.11
강원도농업기술원 옥수수연구소에서 개발된 자색옥수수 색소 1호는 알곡은 노란색인 반면, 알곡을 제거한 속대 와 알곡을 감싸고 있는 포엽에 자색이 발현되는 품종이다. 색소 1호 품종은 포엽과 속대에 안토시아닌 색소가 고 함량으로 집적되는 특징이 있다. 현재 옥수수 포엽은 국내 식품원료로 등록되어 있지 않아 식품원료로 사용할 수 없다. 강원도농업기술원 농식품연구소에서는 자색옥수수 포엽과 속대의 식품활용 범위를 넓히기 위하여 색소 1호 품종의 포엽과 속대 혼합추출물에 대한 독성 및 안전성 평가를 수행하고 식품의약품안전처의 한시적 식품원료 등 록(식품원료 한시기준 제2017-5호)을 추진하였다. 사용대상식품 및 사용량은 100g당 과자 및 액상차 0.51g 이하, 빵 류, 식초 0.17g 이하, 탁주 0.059g 이하로 허용된 범위 내에서 식품원료로 사용 가능하다. 추출물이 적용 가능한 식 품 중 안토시아닌 함유 액상차를 개발하였고 개발된 제품의 저장시험을 통하여 안토시아닌 함량 및 품질 변화를 측정하였다. 저장온도는 25℃, 35℃, 45℃로 설정하였고 총 12주 동안 3주마다 총 안토시아닌 함량 및 당도, pH, 색 도, 대장균수 등을 측정하였다. 실험기간동안 당도 및 pH의 유의적인 변화는 없었으며 대장균은 모든 기간 동안 검출되지 않았다. 총 안토시아닌 함량은 온도가 높을수록 높게 측정되었는데 저장기간이 길어짐에 따른 색차변화 와 연관성이 있으며 총 안토시아닌 측정 시 흡광도에 영향을 주었을 것이라 판단된다. 본 실험결과는 추후 개발되 는 액상차류 제품의 유통기한 및 유통온도, 품질 등을 설정하기 위한 기초자료로 사용하고자 한다.
이기연,이수철 용인대학교 산업경영연구소 2007 산업경영논총 Vol.14 No.-
M&As have been occurred in the field of I.T not only in foreign countries but also in Korea. I.T. venture corporations conduct M&As for establishing a new income-generating-model, acquiring steady income, and survival or growth. At the early stage of I.T venture M&As, M&As had been occurred among I.T venture corporations, however, recently occurred among I.T venture corporations and general corporations, especially among on-line corporations and off-line corporations. Most studies on M&As have been conducted for general corporations not for I.T. corporations. The purpose of this study is to propose M&A strategies for I.T. corporations. This study reviews previous theories and I.T. corporations' M&As cases to draw effective I.T. corporations' M&As strategies. This study finds out that future I.T. corporations' M&A will be executed among heterogeneous industries rather than homogeneous industries. M&A through intermediaries can help to reduce information uncertainty and insymmetry which are sources of costs and lead to increase efficiency. Also, M&As will be executed for contents developing corporations, and the cases of M&As will increase among e-commerce corporations.