활천을 여는 글 : 여교역자회전국연합회 신임회장 - 이군자 전도사 ( mini interview )

이군자 기독교대한성결교회 활천사 2002 활천 Vol.587 No.-

최루가스(o-Chlorobenzylidene Malononitrile)가 흰쥐의 각막과 결막에 미치는 영향

이군자 서울보건대학 1995 서울보건대학 부설 한국보건과학연구소 논문집 Vol.2 No.1

Two groups of rats were exposed to the o-chlorobenzylidine malononitrile(CS) being used in the control of riots, and sacrificed to examine histological and histochemical changes of the cornea and conjunctiva. 1. In animals exposed to the CS gas (50mg/min./㎥) for 20min., reversible histological changes were observed in the cornea. Epithelial and endothelial Na,^(+) K^(+) -ATPase activity were reduced, wing cells of the epithelium were transformed to the squamous shape and mitotic activity occurred actively in the basal layer. 2. In animals exposed repeatedly to the CS gas (50mg/min./㎥) for 20min. once a day for 10 days, Na^(+), K^(+)-ATPase, Mg^(2+)-ATPase and alkaline phosphatase activities of the corneal epithelium and endothelium were reduced. And there was epithelial shrinkage, irregular basement membrane and irregularly arranged collagen fibers were also observed in the stroma. 3. In animals exposed to the CS gas (50mg/min./㎥) for 20min., reversible histological changes were observed in the conjunctiva. Mucin secreting activity of the goblet cells was reduced and lymphocytes, eosinophils were infiltrated. 4. In animals exposed repeatedly to the CS gas (50mg/min./㎥) for 20min. once a day for 10 days, irreversible changes were observed. Desquamation with oedema and shrinkage of the epithelial cells, and loss of some basement membrane were observed. Mucin secreting activity of the goblet cells was reduced and lymphocytes, eosinophils were infiltrated significantly. As a result when eyes are temporally exposed to the CS gas reversible degenerative changes, desquamation with oedema of the epithelium and infiltration are produced. And when eyes are repeatedly exposed to the CS gas histopathologic changes such as desquamation with oedema of the epithelium, infiltration, and reduced mucin secreting activity are occurred.

태생기 및 신생기 흰쥐 간장에서의 Putrescine 대사에 관한 연구

이군자 서울保健大學 1992 論文集 Vol.12 No.1

미숙아의 제반사항 및 간호에 관한 임상적 고찰

李君子 中央醫學社 1974 中央醫學 Vol.26 No.4

This clinical study was done 85 premature infants among 803 new born babies delivered during three years from the January 1, 1971 to December 31, 1973 at the Department of Obstetrics and Gynecology of Inchon Provincial Hospital. The premature infants who weighed under 2500 gm were chosen as the subject ,of this study and as a result their related matters and considerations on clinical _nursing care were as follows. 1) The birth incidence of the premature infants was 10.6%. 2) The distinction of sex. in premature infants was 48 cases (56.5%) of female and 37 cases (43.5%) of male. 3) The birth weight of premature infants was 23 cases (27.0%) belong to the group of 2251-2500 gm which was the top, and the average birth weight was 1915.5 gm in male and 1898.4 gm in female, therefore their both average birth weight was 1907 gm. It showed that the male weighed more than, the female by 17.1 gin and as they weighed more their numbers increased. 4) The number-of the twins in. the premature infants was 14 cases (16.5%). 5) The birth length of premature infants was 48 cases (68.3%) were under 47 cm and the 7 cases (8.2%) were over 50 cm. 6) The gestation period of premature infants was 55 cases (64.7/) were under 37 weeks and 20 cases (23.5%) were over 40 weeks. 7) The mothers who gave birth to premature infants were from 26 to 30 years old and the number of them was topped by 30 cases (38.0%). 8) The mothers who had maternal diseases in the period of-pregnancy were 39 cases (49. 4%) and no problems or others were 40 cases (50.6%). Judging from what it revealed, toxemia was the greatest . in number by 15 cases (19.0%). 9) The parity of premature infants was the first babies were the greatest in number by 38 cases (44.7%'). It indicated that the higher in parity, the lower in number. 10) Monthly delivery number of premature infants was 28 cases (32.9%) topped in figure were born from March to May. 11) The delivery type of premature infants was .27 cases (31.88%) topped in number were extracted by vacuum. 12) The mothers who gave birth to, premature infants was 49 cases (62.0%) had not received prenatal care and 30 cases (38.00) had. 13) The dead of premature infants was 15 cases (17.7%).

신생아 집중치료실에서 퇴원한 환아 부모에게 전화상담한 내용과 간호중재에 대한 조사연구

이군자 京畿專門大學 2000 京畿專門大學 論文集 Vol.- No.28

The purpose of this study was to identity the current status of nursing intervention by telephone. A head nurse of the intensive care unit wrote down the content of interview with parents of newborn discharged from hospital from 7 a. m. to 3 p. m. during the period of February through December in 1999. The content of 150 telephone calls except incomplete record among 460 calls were analyzed into frequency of general characteristics, content and nursing intervention by 11 categories. The findings of this study were as follows; 1. The proportion of males to females, male patients(50.0%) female patients(50.0%) by the ratio of 1:1 and the most common age was 1-2 weeks. 2. The most common admission period was within 1 week. 3. The most common diagnosis during admission period was jaundice, premature. 4. The most frequent contents were physical symptoms and vital sign, a jaundice and diarrhea among physical symptoms, fever and respiratory difficulty among vital sign. 5. Nursing intervention through telephone was identified with order to confirmation, direction, education, inducement. 6. The most frequent nursing intervention by telephone was good condition in confirmation, diarrhea in direction, feeding amount in education, follow up care in inducement. These results suggest that telephone call intervention program should be established as afield of extended pediatric nursing role in health care delivery system for the newborn.

운동프로그램이 중년비만여성의 체구성, 체력 및 지질대사에 미치는 효과

이군자 한국간호과학회 2005 Journal of Korean Academy of Nursing Vol.35 No.8

Purpose: This study was to examine the effects of an exercise program for middle-aged obese women. Method: The exercise program combined folk dance and resistance training. The subjects group consisted of 85 middle-aged obese women between 40 and 60 years of age. Three 8 week sessions consisted of a 55-80% maximum heart rate (MHR) exercise for 60-90 minutes a day and 3 times a week from March to November, 2004. Data was collected through a pre- and post-exercise test before and after each session. Data was collected with Inbody, dynamometer and blood. This data was analyzed by descriptive statistics, and a paired t-test with an SPSS/PC(10.0 version) program. Results: There were significant positive changes in body weight, body fat mass, body mass index, percent body fat, muscle strength, muscle endurance, flexibility, and balance quality, but no significant positive changes in skeletal mass, fat free mass, percent abdominal fat(waist-hip ratio), visceral fat area, agility, total cholesterol, high density lipoprotein cholesterol, or triglycerides. Conclusion: This study showed that an exercise program has partially positive effects for middle-aged obese women. The results of this study show that exercise at community health centers should continue for middle-aged obese women's health.

흰쥐 태반의 Transamidinase 촉매반응에 관여하는 아미노산 잔기의 화학변형

이군자,조영동 한국생화학회 1993 BMB Reports Vol.26 No.8

흰쥐 태반으로부터 transamidinase를 정제한 후 화학변형의 방법을 이용하여 이 효소의 활성부위에 존재하는 아미노산 잔기를 확인하였다. Transamidinase는 sulfhydryl기와 특이하게 반응하는 N-ethylmaleimide, 5'-dithiobis(2-nitrobenzoate)에 의하여 빠르게 활성이 감소되었으며, N-ethylmaleimide에 의한 비활성 반응은 pseudo first-order kinetics로 나타났고 2차 반응속도 상수는 904M^(-1)·min^(-1) 이였으며 반응차수는 0.8이었다. N-ethylmaleimide에 의한 효소의 비활성은 가역반응으로 dithiothreitol에 의하여 활성이 회복되었으며, 기질인 L-arginine에 의하여 보호효과를 나타내었다. 이 효소는 serine과 특이하게 반응하는 diisopropylflurophosphate에 의해서도 비활성되었으며 이 때의 2차 반응속도 상수는 74M^(-l)·min^(-1), 반응차수는 1.1이었다. DFP에 의한 효소의 비활성은 기질인 L-arginine과 glycine에 의하여 모두 보호효과를 나타내었다. 이러한 결과로부터 cysteine과 serine 잔기가 각각 1개씩 이 효소의 활성에 관여할 것으로 추정된다. We examined the chemical modification of the purified rat placenta transamidinase. The enzyme was inactivated by sulfhydryl group specific modification reagents such as NEM and DTNB. The enzyme was turned out to be inactivated by NEM rapidly and the reaction followed pseudo first-order kinetics. The second-order rate constant and reaction order with respect with NEM were 904M^(-1)·min^(-1) and 0.8, respectively. Inactivation by the NEM was restored to almost orginal activity by DTT and was protected by the L-arginine. The transamidiase was also inactivated by the DFP. The second-order rate constant and the reaction order with respect to DFP were 74 M^(-1)·min^(-1) and 1.1, respectively. L-arginine and glycine provided almost complete protection against inactivation by DFP. Such cumulative results suggest that cysteine and serine residues seems to be involved in enzyme activity.

경기지역 대학생의 측면 얼굴형태에 관한 계측적 연구

이군자,안동춘,이관형 대한시과학회 2000 대한시과학회지 Vol.2 No.1

머리와 얼굴의 체질인류학적 특정온 환경척 요인에 의해 크게 달라지지 않으며 인 종과 민족올 구별할 수 있는 특정이다. 얼굴형태는 나이, 성별, 인종에 따라 달라지므 로 나이, 성별, 인종에 따라 해부학적 자료가 계측되어야 한다. 따라서 본 연구에서는 외상 및 전신질환이 없는 20-30세 사이의 성인 581 명(남자 껑4명, 여자 327 명)을 대 상으로 한국인의 측면 얼굴형태를 파악할 수 있는 여러 계측항목율 성벌과 좌우 얼 굴변에 따라 측정하고 분석하여 다옵과 같은 결과훌 얻었다. 한국인 측면얼굴에서 tr - g 직선거리는 성벌에 따라 차이가 없으나 그 이외의 계 측항목에서는 좌우얼굴에서 뚜렷하게 차이가 나타났고 남자의 계측값이 여자보다 더 길며 성벌에 따라 뚜렷한 차이가 나타났으며, 좌우 얼굴의 계측항목은 서로 높은 상 관관계를 나타냈다. 한국인에서 귀구슬최고점은 기준선보다 상측에 위치하며, 전면귀 구슬경사각은 개인에 따라 편차가 큰 것으로 나타났다. The anatomical structures of the head and face are not influenced by environmental factors but v따y from one race to the other. So the fad외 and ocular dimensions have to be measured for a given age, population group and sex. This study was therefore undertaken to determine norrnal values of later side of the face in the 581 Korean college students free from systemic and ocular diseases or anomalies. All measurements except tr - g distance are significantly different between sexes and side of the lateral, but measurements of the lateral faces show a significant correlation each other. Superaurale is superior than HRL in the Korean face and AOH show a lots of deviation among the subjects. *Abbreviations: g, glabella; tr, trichion; HRL, horizontal reference line; AOH, angle between otobasion su야rius and horizontal reference line

Mouse 신장으로부터 Ornithine Decarboxylase의 정제

이군자,조영동 한국생화학회 1992 BMB Reports Vol.25 No.5

자성 mouse의 피하층에 testosterone을 투여하여 ornithine decarboxylase의 활성을 증가시킨 후, 신장으로부터 ornithine decarboxylase를 황산암모늄 분별침전, DEAE-sephacel chromatography, hydroxylapatite chromatography, pyridoxamine-5'-phosphate agarose affinity chromatography를 이용하여 분리 정제하였다. 이 효소의 분자량은 SDS-polyacrylamide gel electrophoresis, Sephacryl S-200 gel chromatography와 ornithine decarboxylase의 효소활성 억제제인 14C-DFMO 을 효소와 결합시켜 얻은 autoradiography를 이용하여 52,000 dalton인 동일한 subunit으로 구성된 dimer임을 알 수 있었다. 정제된 효소의 ornithine에 대한 K_(m) 값과 V_(max) 값은 각각 167㎛과 5 nmol CO_(2)/h로 나타났고, pyridoxal-5-phosphate에 대한 K_(m) 값과 V_(max) 값은 각각 0.142㎛과 2.4nmol CO_(2)/h로 나타났다. 효소의 최적 pH 는 7.0, 최적 온도는 37℃이었으며, 정제된 ornithine decarboxylase는 polyamines(putrescine, spermidine, spermine)에 의해 효소 활성이 영향을 받지 않았다. 본 실험에서는 ornithine decarboxylase의 분리과정 중에서 ornithine decarboxylase 활성을 안정화시키는 물질을 발견하였다. Ornithine decarbosylase (ODC) was purified to homogenity from testosterone treated mice kidney by ammonium sulfate fractionation, DEAE-Sephacel chromatography, hydroxylapatite chromatography, pyridoxamine-5-phosphate-agarose affinity chromatography. The specific activity of ODC was 14,000 U/㎎, and purification fold was 1,180. The enzyme has a Mr. of about 110,000 dalton and is a dimer of subunit Mr. 52,000. The K_(m), for L-ornithine was 167㎛ and for pyridoxamine phosphate, 142 nM. ODC has an optimum pH of 7.0 and optimum temperature of 37℃. The purified enzyme was not inhibited by polyamine (putrescine, spermidine and spermine). During purification process, ODC stabilizing material was found.

日本紀行 : 이웃나라 일본의 인상

이군자 경기대학 관광학회 1967 觀光學報 Vol.1 No.-