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Cytochrome P450 1A1(CYP1A1)과 Glutathione S-Transferase P1(GSTP1) 유전자 다형성이 후두암 발생에 미치는 영향
이국행,심윤상,이용식,이병철,성명식,홍영준,김현주,김헌,김용정 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.1
Background and Objectives:Smoking has been reported as an important risk factor of laryngeal cancer. Cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase P1 ( ) are genes that encode enzymes which are involved in the metab-olism of carcinogens in cigarette smoke. In this study, we statistically tested the significances of smoking and genotypes of CYP1A1 and GSTP1 as risk factors of laryngeal cancer. Materials and Method:In this case-control study, 84 pathologically proven laryngeal cancer patients and 168 age- and sex-matched controls were included as the study subjects. Information on smoking habit was collected using a self-administered questionnaire, and CYP1A1 and GSTP1 genotypes were analyzed using . Results:Smoking was turned out to be a significant risk factor of laryngeal cancer both in univariate and multivariate ana-lyses. The CYP1A1 Ile/Ile genotype was significant in the univariate test, but the statistical significance disappeared in the multivariate conditional logistic model including smoking. The odds ratio (95% confidence interval) of GSTP1 A/A geno-type for laryngeal cancer was 0.71 (0.38, 1.3), which was not statistically significant. Conclusion:Smoking is the most potent risk factor among the thre factors, and the genotypes of CYP1A1 and GSTP1 would not be major risk factors for laryngeal cancer in Koreans. (Korean J Otolaryngol 2002;45:56-61)
이국행,강현식,정길환,이해익,신충옥 全北大學校 科學敎育硏究所 2001 과학과 과학교육 논문지 Vol.26 No.-
The E-O modulator from ZnTe;In single crystals was made in the present study and tested out its properties of modulation in available frequency ranges. Also, the several characteristics of ZnTe;In crystals have been specified.
Dihydro-octa-aze 〔14〕 annulene의 반응성에 대한 HMO의 응용
이국행 全北大學校 基礎科學硏究所 1979 基礎科學 Vol.2 No.1
Frontier orbital energy and superdelocalizability, bond order for macrocyclic ligands have een studied using HMO. As a result of these and relate studied, macrocyclic ligands will be easily excited, ΔEπ of the factors affecting stabilization are in the order of MACY-2>MACY-1 ligand.
이국행,권영조,정연우,이지웅 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.11
Actinomycosis is a chronic and suppurative infection caused by an endogenous Gram-positive bacterium. The usual sites of infectionare the head and neck, thorax, and abdomen. Primary cutaneous actinomycosis is very rare and usually associated with externaltrauma and local ischemia. We report on the case of a primary cutaneous actinomycosis of the nasolabial fold in a 70-year-oldwoman. The patient had a well-defined subcutaneous nodule on the nasolabial fold without any other lesion. The patient was treatedsuccessfully with surgical resection and combined antibiotic therapy. There has been no recurrence during the 3 months period offollow-up. (Korean J Otolaryngol 2006;49:1126-9)
국소 진행된 갑상선암의 수술 – 기관 및 후두, 식도침범의 치료
이국행,강주용 대한갑상선학회 2018 International Journal of Thyroidology Vol.11 No.2
Most thyroid cancers are well-differentiated cancers and have a very good prognosis. About 10% of thyroid cancer, however, invades the surrounding tissues, causing local recurrence and distant metastasis, and eventually affecting survival rate. In locally advanced thyroid cancers, the invasion of trachea, larynx and esophagus, can be occurred by primary tumor and may also result in lymph nodes metastasis. Surgical resection is still mainstay for the treatment of locally advanced thyroid cancer. The main purpose of the surgical resection is to eliminate the cancer completely, therefore, it can cause many complications such as dysfunction of the larynx, trachea and esophagus. It can have a serious effect on the quality of life, therefore there is still controversy on the extent of the surgery. The authors compare and analyze the opinions which were already discussed in the literatures published so far. These will help to select the surgical method.
李國行,尹良重,朴鎭夏 全北大學校 文理科大學 1977 論文集 Vol.5 No.-
The second-order rate constants for the reactions of phenacyl halides with piperidine in anhydrous acetone were determined, and the activation parametrs were also evaluated. It was found that the phenacyl bromide was more reactive about 222 times than the phenacyl chloride toward the piperidine, and that the values of entropies of activation were quite negative and those of enthalpies of activation were comparatively low. It, therefore, may be concluded that the reactions were to be S_N2 mechanism. Arguments are presented against the application of Kirkwood's equation in the reaction of phenacyl bromide with piperidine.
이국행,이병철,권영조,정연우 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.9
Synovial sarcomas is a mesenchymal tumor that usually occurs in the extremities. Fewer than 100 cases of synovial sarcoma havebeen reported in the head and neck lesion. We experienced 2 cases of synovial sarcoma of neck, and so reported with a review ofliterature. (Korean J Otolaryngol 2006;49:952-5)