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윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-
Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.
탈희동결건조골과 이종골이 사람태아 골모세포의 골형성에 관한 효과
윤호상,최희인,유형근 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.1
The ultimate goal of periodontal disease therapy is to promote the regeneration of lost periodontal tissue, there have been many attempts to develop a method to achieve this goal. The purpose of this study was to evaluation the effects of BBP, DLB on bone formation in human fetal osteoblasts. We examined the effect of BBP, DLB on collagen synthesis of human fetal osteoblasts. Collagen synthesis level of 5mg of BBP(5.80±0.18㎍/mg/ml), DLB(5.51±0.57㎍/mg/ml) showed significant difference compare with control group(3.58±0.35㎍/mg/ml). We also examined expression of BMP-2 by Western blot analysis. BMP-2 was expressed in both of BBP and DLB. These results suggest that BBP, DLB have an inductive effect on bone formation in vitro increasing with collagen synthesis and expression of BMP-2.
윤호상,최홍대,강병원 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1
A new method for felbinac, which is a potent anti-inflammatory agent, is described. Friedel-Crafts reaction of biphenyl with ethyl α-chloro-α-(methylthio)acetate(1) afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(4). Felbinac (7) was synthesized by desulfurization of compound (4) with zinc dust in acetic acid, followed by hydrolysis of the resultant ethyl 2-(4-biphenylyl)acetate(6).
윤호상,손병화,강병원,최홍대,정우진 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1
A new method for xenbucin, which is a antihypercholesteremic agent, is described. Friedel-crafts reaction of biphenyl with ethyl α-chloro-α-(methylthio)acetate(1) afforded ethyl 2-methylthio-2-(4-biphenylyl)actate(2). Ethyl 2-(4-biphenylyl)butyrate(4) was obtained by ethylation of (2) with NaH and C₂H^5I, followed by desulfurization of the resultant ethyl 2-methylthio-2-(4-biphenylyl)butyrate(3) with zinc dust in acetic acid. Xenbucin was synthesized by hydrolysis of (4).
윤호상,백두권 한국경영과학회 1990 한국경영과학회 학술대회논문집 Vol.- No.1
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