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윤정한,조한진,Hyun Sook Lee,Cha-Kwon Chung,강영희,Yeong Lae Ha,Hyun-Suh Park 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.3
We previously demonstrated that a mixture of conjugated linoleic acid (CLA) isomers decreases colon cancerincidence in rats treated with 1,2-dimethylhydrazine. Our in vitrostudies have also shown that CLA inhibits the growth ofHT-29 cells, a human colon cancer cell line. When we compared the individual potencies of the two main isomers found inthe mixture of CLA isomers (e.g., cis-9,trans-11 [c9t1] and trans-10,cis-12 [t10c12]), t10c12 CLA decreased viable cellnumbers in a dose-dependent manner. By contrast, c9t11 CLA had no effect. Therefore, the present study examined whetherthe decreased cell growth is related to changes in secretion of insulin-like growth factor (IGF)-II and/or IGF-binding proteins(IGFBPs) that have been shown to regulate HT-29 cell proliferation. Cells were incubated in serum-free medium with vari-ous concentrations of the individual CLA isomers, and immunoblot analysis of 24-hour, serum-free, conditioned media usinga monoclonal anti-IGF-II antibody was performed. HT-29 cells secreted both mature 7,500 aparent molecular weight (M r)and higher-M r forms of IGF-II. t10c12 CLA decreased the levels of the higher-M r and the mature form of IGF-II in a dose-dependent manner, whereas c9t11 CLA had no effect. Ligand blot analysis of conditioned medium using 125I-IGF-II revealedthat the production of IGFBP-2 and IGFBP-4 was also decreased by t10c12 CLA, whereas c9t11 CLA had no effect. Ex-ogenous IGF-II abrogated the growth inhibition induced by t10c12 CLA. These results indicate that inhibition of HT-29 cellgrowth by t10c12 CLA may be mediated by decreasing IGF-II secretion in these cells.
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윤정한,박양수,심수만,이해원 한국세라믹학회 1999 한국세라믹학회지 Vol.36 No.6
Ceramic tapes were fabricated by ultrasonically spraying slurries of monodispersed spherical and alumina powders. Effects of slurry compositions on tape forming were investigated. A relatively fast rate of solvent evaporation caused pores and cracks to be formed. A good chemical affinity between solvent and binder gave rise to binder separation resulting in inhomogeneous distribution of binder. Defect-free silica tapes with uniform distribution of particle packing and the binder were obtained from the solvent having a low chemical affinity and a slow evaporation rate and containing appropriate amounts of the binder and the plasticizer. Tape thickness could be controlled by adjusting solids loadings and slurry feed rates. It was possible to fabricate a tape in 15 $\mu\textrm{m}$ thickness from 7 vol% alumina slurry.
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