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Methamphetamine 이 면역장기 및 항체생성능에 미치는 영향
선우연(Woo Yearn Sun),한형미(Hyung Mee Han),윤은이(Eun Yi Yoon),신전수(Jeon Soo Shin),박현애(Hyeon Ae Park),김미영(Mi Young Kim) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.1
BALB/c mice were intraperitoneally injected with methamphetamine (5 mg/kg) to observe the effect of methamphetamine on the immune system. Body weights were decreased in both acutely treated group (twice for 2 weeks with 7 days interval) and subchronically treated group (daily injection for 14 days). The relative spleen weights and the numbers of splenocytes were unexpectedly increased (p<0.05) in acutely treated group, but subchronically treated group showed the trend of decrease without significance. But there was no significant effect on antibody formation to hen egg lysozyme which was immunized during the treatment of methamphetamine and on plaque forming cell number. The relative thymus weights of both groups were significantly decreased by the treatment of methamphetamine (acutely treated group, p<0.05; subchronically treated group, p<0.01). These results suggest that the effect of methamphetamine on the immune system may be caused by thymic dysfunction.
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수은이 시험관내 사람 다형핵백혈구의 기능에 미치는 영향
김효정,한형미,김순한,김옥연,선우연,윤은이 한국응용약물학회 1993 Biomolecules & Therapeutics(구 응용약물학회지) Vol.1 No.2
In the present study, the effect of HgCl₂ on the function of human peripheral polymorphonuclear leukocytes(PMNs) was examined. PMNs were isolated from human peripheral blood with density centrifugation in Ficoll-Paque. The cells were then incubated with 0.5∼5 μM HgCl₂ and glass adherence, chemotactic activity and erythrocyte-antibody rosette forming activity were measured. HgCl₂ decreased the function of PMNs in all three aspects tested. HgCl₂ significantly diminished glass adherence(0.5 μM: 92±12% (percentage of control, mean±S.D.); 1μM: 46±11%, P<0.01; 3 μM: 35±7%, P<0.01; 5 μM: 49±10%, P<0.01). Similarly, significant differences were observed in chemotactic activity after HgCl₂ treatment compared with control (control: 0.95±0.14 mm; 0.5μM: 0.91±0.11 mm; 1μM: 0.77±0.16 mm, P<0.05; 3μM: 0.61±0.06 mm, P<0.01; 5μM: 0.15±0.03 mm, P<0.01). Also, HgCl₂ decreased the percentage of rosette-forming PMNs, indicating diminished phagocytic activity of PMNs upon HgCl₂ exposure compared with control (control: 58±4%; 1 μM: 53±4%, P<0.05; 3 μM: 49±3%, P<0.01; 5 μM: 46±3%, P<0.01). Cell viability was not altered after HgCl₂ treatment (83±5% viability in control PMNs versus 81±8% viability in 5 μM HgCl₂-treated PMNs), suggesting that the impaired PMN function after HgCl₂ treatment was not due to nonspecific cytotoxicity induced by HgCl₂. HgCl₂-induced decrease in the function of PMNs may have some implications in depressed host susceptibilityupon bacterial challenge after mercury exposure.
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