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윤대성,나유미,고대경,김윤미,김금원,이회영,Yu-Ling Xin,Wei Zhang,Zing-Hong Li,권희욱 한국유방암학회 2007 Journal of breast cancer Vol.10 No.2
Purpose: To introduce the history and principle mechanism of electrochemical treatment (EChT) with animal study and report two cases successfully treated breast cancer and hemangioma by EChT. Methods: In animal study, the breast cancer tumor in nude mouse treated with EChT (100 Coulomb/cm3) were reviewed for histologic changes. In the case studies, we reported method of EChT and clinical results after EChT. Case 1: 74 yr old female with locally advanced breast cancer received 3 times EChT with 1,000 Coulomb/time, 8 Volt. Case 2: 51 yr old female with breast hemagioma received one time EChT with 80 Coulomb, 8 Volt. Results: In animal study, There were destructive change including vaculated cell fragment and extensive coagulative necrosis. Case 1 showed no local recurrence during 18 monthes after EChT. Case 2 also showed no evidence of recurrence of hemangioma. Conclusion: The EChT is easy to use. It is effective, safe, less traumatic and makes patients recover quickly. This is a new and effective method to treat patients with tumours that are inoperable and can not receive chemotherapy or radiotherapy.
유방암 세포에서 Fatty Acid Synthase 발현에 미치는 Genistein의 효과
윤대성 한국유방암학회 2007 Journal of breast cancer Vol.10 No.2
Purpose: The relatively low incidence of breast cancer in Asian countries with cultures which traditionally eat a large amount of soy is worth noticing in research fields. Genistein is a isoflavone phytoestrogen found in soy and its consumption may have a role in cancer etiology. We have established a hypothesis that a diet high in soy consumption is related to a low incidence of breast cancer. Fatty acid synthase (FAS) is a multi-protein enzyme responsible for de novo biosynthesis of fatty acids. Recent studies have demonstrated that high levels of FAS occurs in a subset of human cancers, such as breast cancer, ovarian cancer, and prostate cancer. High level of FAS are associated with a poor prognosis. Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate genes involved in lipid metabolism, including FAS. Recent studies show that expression of SREBP1c is correlates with FAS expression. The aim of this study is to investigate the effect of genistein on the expression of FAS in breast cancer cells. Methods: We performed immunofluorescent staining to examine the expression of FAS under different concentration of genistein. RT-PCR was also performed to investigate the mRNA expression of FAS and SREBP1c in different conditioned breast cancer cells treated with different concentration of FAS inhibitor and genistein. Results: By immunofluorescent staining, the FAS expression after treatment with the FAS inhibitor, C75, decreased at a 10 M concentration. However the expression of FAS decreased at all concentrations of genistein (0.5, 1, 5, 10 M). The mRNA levels of FAS and SREBP1c after treatment with C75 decreased constantly according to time and concentration. However the effect was noted only after 12 hr. The mRNA level of FAS and SREBP1c following treatment with genistein decreased at only a 10 M concentration (p<0.005). Conclusion: Genistein may down regulate FAS expression in breast cancer cells through modulation of SREBP-1c. This finding may account for the relatively low incidence of breast cancer in Asians who consume a large amount of soy in their diet.
Recent Research Trends in Nanoscale Electro-mechanical Systems for Bio-medical Applications
윤대성,Su Ho Chung,최범준,이상우 대한의용생체공학회 2011 Biomedical Engineering Letters (BMEL) Vol.1 No.1
For the past decade, researches seeking systematic understanding of molecular interactions or biological behaviors in single cells at single-molecule resolution, have been intensively done by many scientists. Accordingly, much attention regarding biomedical applications of nanoscaleelectro-mechanical systems (NEMS) has been given to single molecule-level biosensor/bioelectronics and in vivo diagnostics in a single biological cell. This trend has served as the fuel of the development in the field of NEMS for biomedical applications. That development of the NEMS techniques has also made contributions to advance the understanding of the molecular interaction or the biological behaviors. Therefore, one of the most valuable topics is to review novel NEMS techniques that can be applied in the biomedical and clinical fields. In this article, we briefly survey important and notable results among recent research activities in NEMS, and discuss their importance and possible applications in relevant fields.