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여재익,함휘찬,김용현,육승근 한국생산제조학회 2019 한국생산제조학회지 Vol.28 No.6
A microjet with a velocity of approximately 140 m/s and 150 μm diameter is injected into a narrow nozzle by a pressure wave delivered by laser-induced bubble expansion. The driving force of such an injector is a discontinuous pulse of a 10 Hz period. Every time a pulse ends, unnecessary air bubbles are introduced into the injector due to the decrease in its internal pressure. Such air bubbles interfere with the flow inside the injector, deteriorating its performance. Therefore, we developed a nozzle closure that reacts automatically to the driving force with a pulse shape. When the flow occurs, the nozzle is opened; when it does not, the nozzle is closed to prevent unnecessary air inflow. In this study, a microjet injector was applied to needle-free drug injection. We compared and analyzed the drug penetration performance of the injector with and without the nozzle closure attached to the injector.
절연파괴 현상을 구동력으로 하는 마이크로젯 인젝터 개발
함휘찬(Hwi-chan Ham),김용현(Yong-hyun Ghymn),육승근(Seung-keun Yook),여재익(Jai-ick Yoh) 한국생산제조학회 2020 한국생산제조학회지 Vol.29 No.1
Drug delivery via microjets is a method that can potentially overcome the disadvantages of conventional needle injections. We implemented a microjet injection system that operates with spark-generated bubbles. The system consists of three components: a battery, power supply system, and microjet injector, which allows 10-20 discharges and microjet injections per second. In order to increase discharge efficiency, the circuit elements and electrode shapes were optimized and the flow inside the discharge chamber was operated to minimize the influence of metal colloids generated by electrode erosion. The microjet ejection was captured by a high-speed camera to correlate the energy of the spark discharge with microjet characteristics in order to make the system suitable for transdermal drug penetration.