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온영근 대한부정맥학회 2017 International Journal of Arrhythmia Vol.18 No.1
Køber L, Thune JJ, Nielsen JC, Haarbo J, Videbæk L, Korup E, Jensen G, Hildebrandt P, Steffensen FH, Bruun NE, Eiskjær H, Brandes A, Thøgersen AM, Gustafsson F, Egstrup K, Videbæk R, Hassager C, Svendsen JH, Høfsten DE, Torp-Pedersen C, Pehrson S; DANISH Investigators. N Engl J Med. 2016;375:1221–1230.
온영근,현민수,김성구,권영주 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Cushing's syndrome is produced by the hypersecretion of adrenal glucocorticoids and is characterized by moon face, central obesity, disappearance of diurnal variation of plasma cortisol and unsuppressibility of plasma cortisol by low dose dexamethasone. We report two cases of adrenal mass manifested with hypertension. One of the cases is adrenal macronodular hyperplasia and the other case is adrenal adenoma. Abdominal CT revealed well defined adrenal tumor in both cases. Laparoscopic adrenalectomy was performed and hypertension disappeared after operation.
온영근(Young Keun On),김상현(Sang Hyun Kim),김효수(Hyo Soo Kim),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young Woo 대한내과학회 1995 대한내과학회지 Vol.49 No.5
N/A Objectives: Different patterns of coronary atherosclerotic involvement between acute myocardial infarction and chronic stable angina have been suggested, however, little data are available in Korean patients. Methods: 22acute myocardial infarction patients (509years, 21males) as his first clinical manifestation and 33chronic stable angina patients(556years, 21males) with at least 2years' duration undertook coronary arteriography. Clinical coronary artery disease risk factors, indices of coronary atherosclerotic involvement such as number of diseased vessels, stenosis score, diffusiveness of the lesion and extent of collaterals were compared between two groups. Results: Compared to acute myocardial infarction group, chronic stable angina group showed more advanced coronary arterial involvement in terms of number of involved vessels(2.0±0.8 vs. 1.1±0.4, p<0.01), stenosis score(6.9±4.3 vs. 2.5±1.0, p<0.01) and diffusiveness(58% vs. 14%, p<0.01), However, prevalence of risk factors for the coronary artery disease were similar in two groups. Conclusion: More advanced coronary arterial involvement in patients with chronic stable angina, compared to that in patients with acute myocardial infarction, might suggest different pathogenetic mechanisms between two disease entities.
고혈압 환자에서 내피의존성 혈관반응에 대한 칼슘길항제와 비타민 C 의 효과에 대한 요구
온영근(Young Yeun On),최진호(Jin Ho Choi),채인호(In Ho Chae),김철호(Cheol Ho Kim),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi) 대한내과학회 2001 대한내과학회지 Vol.61 No.5
N/A Background: The effect s of antihypertensive agents on endothelial function have not been fully evaluated in human hypertension and data on the forearm circulation of humans are controversial. The aim of this study was 1) to evaluate the endothelial function in hypertensive patients 2) to investigate whether vitamin C administration has any benefit on the endothelial function and 3) to determine whether treatment with calcium ant agonist improves endothelial dysfunction in hypertensive patients. Methods: The endothelial function was estimated using venous occlusion plethysmography (VOP) in 8 hyper tensive patients and 8 healthy volunteer s. The patients in the hypertension group were treated with amlodipine, then examined again. The change of forearm blood flow (FBF) was measured wit hacetylcholine infusion through brachial artery and also with intra-ar terial vitamin C. Results: Forearm blood flow response to acetylcholine was significantly enhanced with intra- arterial infusion of vitamin C in hypertensive group before antihypertensive treatment. Co- infusion of L- NMMA, an inhibit or of nitric oxide synthase, blunted forearm blood flow response toacetylcholine. After treatment with amlodipine for 2 months in hypertensive group, endothelium-dependent vasorelaxation to acetylcholine was significantly improved comparedt opretreatment, and vitamin C did not affect the improved endothelial function by amlodipine treatment. Conclusion: Vitamin C (acutely) and amlodipine (chronically) improved endothelial function inhypertensive patients. These results suggest that increased oxidative stress, at least in part , maybe involved in the decreased endothelial function in hypertension.(Korean J Med 61:518- 526, 2001)
온영근 ( Young Keun On ) 대한내과학회 2011 대한내과학회지 Vol.81 No.4
Atrial fibrillation (AF) is the most common cardiac arrhythmia and its prevalence is expected to increase with increasing age. The risk of stroke also increases substantially with age. There are three strategies for the management of AF, that is, rate control, rhythm control and anticoagulation for prevention of embolism. Antiarrhythmic drugs are usually used for rhythm control as first line therapy but there are some limitations in using antiarrhythmic drugs for AF. Catheter ablation of AF should be considered as second line therapy. The primary indication for catheter ablation is the presence of symptomatic AF refractory or intolerant to antiarrhythmic medication. Warfarin is more effective effective in preventing stroke than aspirin and combination aspirin- clopidogrel. Despite its proven efficacy, warfarin is often not well tolerated by patients, has a very narrow therapeutic range, and has a high risk for bleeding complications. Echocardiography and autopsy studies showed that the left atrial appendage (LAA) was the source of thrombi in more than 90% of patients with non-valvular AF. Percutaneous catheter-based devices have been developed to close and thereby effectively exclude the LAA from the systemic circulation. (Korean J Med 2011;81:428-433)