원보 ; 오메프라졸 - 에칠렌디아민 복합체를 이용한 제제설계

오세종,박성배,박선희,황성주,이계주 ( Sea Jong Oh,Seong Bae Park,Sun Hee Park,Sung Joo Hwang,Gye Ju Rhee ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

The study was carried out to develop useful formulation for omeprazole(OMP) through OMP-ethylendiamine complex(OMPED), and the pharmaceutical properties of formula were tested to find out the difference in vivo behaviors of formulations between the free and complexed OMP. Oral and suppository dosage forms were also formulated and the dissolution profiles and pharmacokinetic parameters were measured to observe the difference in bioavailability between the free and complex form, and the correlation between dissolution rate and bioavailability was evaluated. The results are summarized as follows; In the case of formulation for oral administration, the release of OMP from enteric OMPED pellets was found satisfactory to the requirement standard and no decomposition of OMP in the pellets was found in acidic solution. Therefore the enteric OMPED pellets are anticipated to be a stable formulation. The release of OMP from OMPED tablet with chitosan as excipient and coated with cellulose acetate phthalate was found to be significantly retarded. The results of bioavailability test for OMP and OMPED tablets with lactose-excipient showed that the AUC value of OMP tablet was 116.89 ㎍·min/㎖, that of OMPED tablet was 161.10 ㎍·min/㎖, respectively. The reason why was thought that OMP decomposes more readily in body than OMPED, and the AUC of the tablet with chitosan-excipient and coated with cellulose acetate phthalate was most enhanced. In the case of bioavailability for suppositories with OMP, OMP-β-cyclodextrin complex and OMPED, the AUC of OMPED suppository was most increased. From the above results, it is thought that the more stable and bioavailable oral or rectal dosage forms could be developed by using the OMPED as a potential OMP complex.

원보 ; 오메프라졸의 안정화를 위한 에칠렌디아민 복합체 개발

오세종,김은영,김길수,김윤정,이계주 ( Sea Jong Oh,Eun Young Kim,Kil Soo Kim,Yuon Jeung Kim,Gye Ju Rhee ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

To stabilize omeprazole(OMP), ethylenediamine(ED) complex of omeprazole(OMPED) was prepared by reaction between OMP and ED in methanol, and the complex formation was confirmed by the instrumental analysis, i.e., IR, DSC, EA, NMR, MS and XRD. The rates of decomposition of OMP and OMPED in aqueous solution and the shelf lives at standard temperature were measured by accelerated stability analysis. The results are summarized as follows; The mole ratio of OMP and ED in OMPED complex is 1:1, the energy of formation within OMPED might be combined between polar imidazole group of OMP with induced a dipole amine group in the readily polarizable ED molecule. At standard temperature the degradation rate constant of OMP in aqueous solution is 2.540×10^(-2) hr^(-1) and the shelf life is 4.15 hrs, and in the case of OMPED the degradation rate constant is 7.986×10^(-4) hr^(-1) and the shelf life is 131.96 hrs. So, the OMPED has about 31 times longer shelf life than OMP. The activation energy of OMP and OMPED are 5.23 and 18.55 ㎉ mole^(-1) respectively. The stability of OMP is dependent chiefly on pH in the solutions and it decomposes readily in acidic medium by hydrogen ion catalized reaction but becomes stable beyond pH 9.0. In case of the ED-complex, OMPED is stable in neutral as well as in dilute acidic solutions even in pH 6, OMPED is very stable to light(UV), that is, the rate constant and shelf life of OMP are k=1.0188×10^(-2) day^(-1), T_(90%)=4.5 days, on the other hand, the those of OMPED are k=7.138×10^(-4) day^(-1), T_(90%)=64.1 days, respectively. From the above results, it is thought that new dosage forms could be developed by using the OMPED as a potential OMP complex.

오메프라졸-에칠렌디아민 복합체를 이용한 제제설계

오세종,박성배,박선희,황성주,이계주,Oh, Sea-Jong,Park, Seong-Bae,Park, Sun-Hee,Hwang, Sung-Joo,Rhee, Gye-Ju 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

The study was carried out to develop useful formulation for omeprazole(OMP) through OMP-ethylendiamine complex(OMPED), and the pharmaceutical properties of formula were tested to find out the difference in vivo behaviors of formulations between the free and complexed OMP. Oral and suppository dosage forms were also formulated and the dissolution profiles and pharmacokinetic parameters were measured to observe the difference in bioavailability between the free and complex form, and the correlation between dissolution rate and bioavailability was evaluated. The results are summarized as follows; In the case of formulation for oral administration, the release of OMP from enteric OMPED pellets was found satisfactory to the requirement standard and no decomposition of OMP in the pellets was found in acidic solution. Therefore the enteric OMPED pellets are anticipated to be a stable formulation. The release of OMP from OMPED tablet with chitosan as excipient and coated with cellulose acetate phthalate was found to be significantly retarded. The results of bioavailability test for OMP and OMPED tablets with lactose-excipient showed that the AUC value of OMP tablet was $116.89\;{\mu}g\;{\cdot}\;min/ml$, that of OMPED tablet was $161.10\;{\mu}g\;{\cdot}\;min/ml$, respectively. The reason why was thought that OMP decomposes more readily in body than OMPED, and the AUC of the tablet with chitosan-excipient and coated with cellulose acetate phthalate was most enhanced. In the case of bioavailability for suppositories with OMP, $OMP-{\beta}\;-cyclodextrin$ complex and OMPED, the AUC of OMPED suppository was most increased. From the above results, it is thought that the more stable and bioavailable oral or rectal dosage forms could be developed by using the OMPED as a potential OMP complex.

오메프라졸의 안정화를 위한 에칠렌디아민 복합체 개발

오세종,김은영,김길수,김윤정,이계주,Oh, Sea-Jong,Kim, Eun-Young,Kim, Kil-Soo,Kim, Yuon-Jeung,Lee, Gye-Ju 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1

To stabilize omeprazole(OMP), ethylenediamine(ED) complex of omeprazole(OMPED) was prepared by reaction between OMP and ED in methanol, and the complex formation was confirmed by the instrumental analysis, i.e., IR, DSC, EA, NMR, MS and XRD. The rates of decomposition of OMP and OMPED in aqueous solution and the shelf lives at standard temperature were measured by accelerated stability analysis. The results are summarized as follows; The mole ratio of OMP and ED in OMPED complex is 1:1, the energy of formation within OMPED might be combined between polar imidazole group of OMP with induced a dipole amine group in the readily polarizable ED molecule. At standard temperature the degradation rate constant of OMP in aqueous solution is $2.540{\times}10^{-2}\;hr^{-1}$ and the shelf life is 4.15 hrs, and in the case of OMPED the degradation rate constant is $7.986{\times}10^{-4}\;hr^{-1}$ and the shelf life is 131.96 hrs. So, the OMPED has about 31 times longer shelf life than OMP. The activation energy of OMP and OMPED are 5.23 and 18.55 kcal $mole^{-1}$ respectively. The stability of OMP is dependent chiefly on pH in the solutions and it decomposes readily in acidic medium by hydrogen ion catalized reaction but becomes stable beyond pH 9.0. In case of the ED-complex, OMPED is stable in neutral as well as in dilute acidic solutions even in pH 6, OMPED is very stable to light(UV), that is, the rate constant and shelf life of OMP are $k=1.0188{\times}10^{-2}\;day^{-1}$, $T_{90%}=4.5 \;days$, on the other hand, the those of OMPED are $k=7.138{\times}10^{-4}\;day^{-1}$, $T_{90%}=64.1\;days$, respectively. From the above results, it is thought that new dosage forms could be developed by using the OMPED as a potential OMP complex.

유비쿼터스 시대의 출판 커뮤니케이션 증진을 위한 기초 연구 - 문화기호학적 측면의 텍스트 분석을 중심으로

오세종(Oh Sea-Jong) 한국출판학회 2005 한국출판학연구 Vol.0 No.49

본 연구에서는 미디어 산업에서 중추적인 역할을 하고 있는 출판 커뮤니케이션 산업의 역사성 및 전통성과 밀접하다고 할 수 있는 ‘텍스트 문화의 기호학’과 ‘언설의 기호학적 측면’에서 담론, 즉 신화·민화·설화를 중심으로 접근하였다. 특히 유비쿼터스 출판 시대를 맞이한 현 시점에서, 출판 커뮤니케이션 측면에서 예측되는 정보격차를 해소하기 위한 방안의 일환으로 착안하게 되었으며, 그 기초적 접근 방안의 연구로서 출판 미디어를 통한 커뮤니케이션 문화의 기호학적 접근이 가능하다는 것을 제시하고자, 언설의 기호학과 담론을 통한 기호학의 기초 이론 및 기호학의 구조, 텍스트의 구조분석 방법까지 살펴보았다. 본 연구의 의의는 어떠한 현상이나 이야기의 줄거리를 텍스트화 하고, 기호학적으로 <텍스트>와 <맥락>의 구조를 분석하며, 사회의 다양한 현상과 연관시켜 그 현상을 이해하고 발전시켜 나가는데 그 의의가 있다고 볼 수 있다. 하나의 이야기 또는 문맥, 현상들을 대화적으로 접근하여 텍스화하고 기호화함으로써 기호작용을 통해서 총체적으로 이해하고 의미를 실현해 나가는 가능성이 있다는 것을 본 연구를 통해서 얻은 결론이다. 이러한 결론을 토대로 앞으로의 유비쿼터스 출판산업은 물론 미디어를 통한 커뮤니케이션 산업의 발전에 더욱 이바지 할 것으로 기대하며, 본 연구를 바탕으로 지속적인 관련 연구가 이루어져, 유비쿼터스 출판 환경에 모두가 적응 되어 정보 격차를 해소하는 시기를 앞당겼으면 한다. This study tried to approach with culture text analysis of confabulation(mythology, folktale, tale) on 'text culture semiology' & 'statement semiology' that is close to historicity and tradition of the publication communication industry that has played a key role media industry. Especially, This study tried to solve the knowledge and information gap on Ubiquitous Publication communication. I tried to search basic theory of semiology and structure of semiology, a structure analytical method of a text by semiology of a statement and confabulation so that presented that it was possible approach with communication culture semiology by the media including publication communication A meaning of this study is text a phenomenon or a plot of a story, analyzes structure of <text> and <context> with a semiology, and understanding and developing a various phenomena related to the society This study acquired conclusions that approach with a conversation one story or the context, the phenomenon to text and semiology by semiosis, possibility understanding and realizeing meaning overall. It is based on these conclusions that expected development of the media communication industry including Ubiquitous publication industry. The study which it sees the continuous relation this study becomes accomplished with all to be adapted to Ubiquitous Publication environment, it advances the time which is solved information gap.

논단(論壇) : 출판산업(出版産業)의 CSR 홍보효과(弘報效果) 제고(提高) 요인(要因)에 관한 연구(硏究)

오세종 ( Sea Jong Oh ) 출판문화학회 2008 出版 雜誌硏究 Vol.16 No.1

유비쿼터스 출판 산업의 360° 브랜딩 전략에 관한 연구

오세종 ( Sea Jong Oh ) 출판문화학회 2005 出版 雜誌硏究 Vol.13 No.1

희첨의 Steroid 성분에 관한 연구

오세종(Sea Jong Oh) 한국생약학회 1973 생약학회지 Vol.4 No.2

Five steroids (campesterol, stigmasterol, β-sitosterol, α-spinasterol and stigmast-7-enol) were isolated as mixture from Siegesbeckia pubescens MAKINO and analyzed by mass spectrometry.

연질캅셀제중 수용성 비타민의 젤라틴층 이행에 관한 연구

오세종(Sea Jong Oh),박원희(Won Hee Park),윤광재(Kwang Jai Yun),윤원용(Won Yong Yoon) 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.1

The previous vitamin assays in soft capsules have been performed only with capsule contents. Since some vitamins, however, could migrate into gelatin layer of the soft capsules, each vitamin of multivitamin soft capsules in the market was analyzed simultaneously in both capsule content and gelatin layer. The results showed that migrations of nicotinamide and pyridoxine hydrochloride into gelatin layer were pronounced, while those of other vitamins were negligible.

셀레늄 함유 건조효모제제 중 셀레늄 분석방법에 관한 연구

오세종(Sea Jong Oh),오영택(Young Taek Oh),윤원용(Won Yong Yoon),박성배(Sung Bae Park) 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.1

In order to improve the sensitivity of the current assay methods of selenium in dried-yeast preparations, atomic absorption spectrophotometry (AAS), high performance liquid chromatography (HPLC) and UV-Vis spectrophotometry were employed. The sample was prepared with the digestion by acid mixture of hydrochloric acid, nitric acid and perchloric acid after elimination of ether-soluble substances. The range of quantitation of selenium was 1.0∼6.0 ㎍/㎖ by UV-Vis spectrophotometry, 5.0∼20.0 ㎍/㎖ by HPLC and 0.03∼0.10 ㎍/㎖ by AAS.