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양병환,김석현,이영호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
About 150 years have passed since genetics introduced into the psychiatric fields. Nowadays, due to the development of biological psychiatry, psychiatric genetics become a very important section of the psychiatry, contributing to the research for genetic components of psychiatric disorders. But genetic studies of psychiatric disorders have many problems. One reason of the difficulty is that psychiatric disorders do not follow Mendelian inheritance. Instead, psychiatric disorders seems that they have polygenic and multifactorial inheritance characteristics. The authors reviewed the research methods of psychiatric genetics such as family study, twin and adoption study, segregation analysis, linkage and association studies. Also the problems and issues of the research methods were discussed.
전기경련충격시 경쟁적 역전사 중합효소연쇄반응(CRT-PCR)을 이용한 흰쥐 뇌 c-fos 유전자의 발현 양식 분석
양병환,이제욱,박응철,유재학,조광원,양보기,채영규,Yang, Byung-Hwan,Lee, Jei-Wook,Park, Eung-Chul,Yu, Jae-Hak,Cho, Goang-Won,Yang, Bo-Gee,Chai, Young-Gyu 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
To clarify the mechanism of action of electroconvulsive shack(ECS) in respect to molecular biology, and to detect the quantitative amount of change of c-fos gene expression after ECS in the rat's brain, the authors obtained brain specimens from the striatum, cerebral cortex, hippocampus, and cerebellum. Each brain was removed within 30min. after ECS(130V, 0.5sec) and ECS-sham. Then we performed RT-PCR. The results are 1) ECS was found to affect the expression of immediate early genes. 2) the cerebral cortex and hippocampus was more influenced by ECS thon in the cerebellum and striatum. From these results, we can suggest that ECS is related to the mechanism of cognition, mood, memory which is correlated to cerebral cortex and hippocampus.