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한국산 담자균류의 항암성분에 관한 연구 - 만년 버섯의 균사 배양 및 항암 성분 -
강창율,심미자,최응칠,이영남,김병각 ( Chang Yul Kang,Mi Ja Shim,Eung Chil Choi,Young Nam Lee,Byong Kak Kim ) 생화학분자생물학회 1981 BMB Reports Vol.14 No.2
To find antineoplastic components from Korean higher fungi, the mycelium of Ganoderma lucidum (Fr.) Karsten was grown in shake culture and a protein-bound polysaccharide was isolated. This component suppressed tumor growth of sarcoma 180 grafted in A-strain mice. The component was administered intraperitoneally to the mice at a dose of 50 ㎎/㎏ daily for five days. Ten days later, the mice were immunized with 1×10^7 sheep red blood cells. The number of plaque-forming cells in their spleen was significantly greater than that of control mice. Three monosaccharides and sixteen amino acids were identified from the protein-bound polysaccharide.
맥각균의 배양에 관한 연구(Ⅳ) : 한국산 맥각균의 배양
김병각(Byong Kak Kim),심미자(Mi Ja Shim),최응칠(Eung Chil Choi),박영인(Young In Park) 한국생약학회 1975 생약학회지 Vol.6 No.1
To isolate ergot strains which are capable of growing and producing alkaloids in submerged culture, strains were isolated from the sclerotia parasitizing the Graminae plants in Korea and the experiments of submerged culture of these strains yielded the following results: 1) The mycelia which were respectively isolated from the sclerotia parasitizing Agropyron semicostatum NEES, Arundinella hirta TANAKA var. ciliata KOIDSUMI, Ischaemum anthephoroides MIQ. var. eriostachyum HONDA, and Phleum pratense L. grew in Medium D by submerged culture. 2) When the strain of the ergot of Agropyron semicostatum was inoculated into six different nutrient solutions for submerged culture, its mycelium grew well in Media C, D and F, but produced alkaloids only in Medium C, indicating that Medium C is relatively suitable for the strain. 3) The extraction of the alkaloids from the culture broth by ether and T.L.C. analysis of the extract showed that it contained at least two types of alkaloids.
한국산 담자균류의 항암성분에 관한 연구 -만년 버섯의 균사 배양 및 항암 성분-
강창율,심미자,최응칠,이영남,김병각,Kang, Chang-Yul,Shim, Mi-Ja,Choi, Eung-Chil,Lee, Young-Nam,Kim, Byong-Kak 생화학분자생물학회 1981 한국생화학회지 Vol.14 No.2
To find antineoplastic components from Korean higher fungi, the mycelium of Ganoderma lucidum (Fr.) Karsten was grown in shake culture and a protein-bound polysaccharide was isolated. This component suppressed tumor growth of sarcoma 180 grafted in A-strain mice. The component was administered intraperitoneally to the mice at a dose of 50 mg/kg daily for five days. Ten days later, the mice were immunized with $1{\times}10^7$ sheep red blood cells. The number of plaque-forming cells in their spleen was significantly greater than that of control mice. Three monosaccharides and sixteen amino acids were identified from the protein-bound polysaccharide. 한국산 고등 균류 중에서 항암성분을 탐색할 목적으로 담자균류의 하나인 만년 버섯, Ganoderma lucidum (Fr.) Karsten의 균사를 진탕 배양하여 얻은 균사체와 그 배양여액으로부터 단백다당류를 추출 분리하였으며 종양 억제작용 및 면역에 미치는 영향을 검토하였다. Sarcoma 180 세포를 흰 쥐에 이식한 후 이 단백다당류를 주사하였을 때 60% 이상의 저지율을 나타내었다. 또한 흰 쥐에 이 단백다당류를 5일간 복강내에 주사하여 10일이 지난뒤에 $1{\times}10^7$개의 면양 적혈구를 주사했을 때 용혈반을 만드는 비장세포의 수가 현저히 증가함을 관찰하였다. 이 단백다당류를 산으로 가수분해하여 3종의 단당류과 16종의 아미노산을 확인하였다.
한국산 고등 균류의 성분 연구 ( Ⅵ ) Amanita Spissaceea 및 Amanita Vaginata 의 아미노산
김병각,이영수,최응칠,심미자,이영남 ( Byong Kak Kim,Young Soo Lee,Eung Chil Choi,Mi Ja Shim,Young Nam Lee ) 생화학분자생물학회 1977 BMB Reports Vol.10 No.1
Amanita spissacea which is indiginous to Korea and Japan and Amanita vaginata which is an edible mushroom, grow wildly in Korea. However, their constituents have never been studied. These higher fungi were collected in the Gyeong Gi Province, Korea, and analyzed for their free and total amino acids, using gas chromatography and amino acid auto-analyzer. Fourteen free amino acids (alanine, glycine, valine, leucine, isoleucine, threonine, aspartic acid, methionine, phenylalanine, histidine, tyrosine, lysine, arginine, and tryptophan) were identified in both species. The contents of eight free essential amino acids in A. spissacea and a. vaginata were : threonine 7.26 and 3.15 ㎎/g, lysine 2. 85 and 2.5 ㎎/g, methionine 2.48 and 2.70 ㎎/g, phenylalanine 1.35 and 0.98 ㎎/g, isoleucine and leucine combined 1.65 and 1.05 ㎎/g, valine 1.24 and 0.68 ㎎/g, and tryptophan 0.90 and 0.93 ㎎/g, respectively. The total contents of the respective amino acids in A. spissacea and A, vaginata were: lysine 5.18 and 12.28 ㎎/g, histidine 3.00 and 5.12 ㎎/g, arginine 7.76 and 9.80㎎/g, threonine 8.88 and 8.00 ㎎/g, glutamic acid 20.10 and 34.94 ㎎/g, alanine 10.22 and 11.62 ㎎/g, valine 9.64 and 8.94 ㎎/g, glycine 8.32 and 8.30 ㎎/g, methionine 1.90 and 1. 63 ㎎/g, isoleucine 6.66 and 7.88 ㎎/g, leucine 12.74 and 14.00 ㎎/g, phenylalanine 7.00 and 7.82 ㎎/g, cysteine 0.82 and 1.26 ㎎/g, aspantic acid 16.94 and 15.28 ㎎/g, serine 9.84 and 10.34 ㎎/g and threonine 3.62 and 3.90 ㎎/g, respectively.