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신혜지,정하연,박병덕,이기용 한국생약학회 2016 Natural Product Sciences Vol.22 No.1
A method for simultaneously identifying antioxidative compounds was developed using time-based LC-MS coupled with DPPH assay regardless of the time consuming process. The methanolic extract of Polygonum aviculare (Polygonaceae) showed significant DPPH radical scavenging activity. Time-based DPPH assay for simultaneous identification of active compounds from the extracts of P. aviculare was used. Major peaks of ethyl acetate fraction of P. aviculare showed high DPPH radical scavenging activity. A simple phenolic compound (1) and six flavonoids (2-7) were isolated from the ethyl acetate fraction of P. aviculare by silica gel and sephadex LH-20 column chromatography. The structures of seven compounds were determined to be protocatechuic acid (1), catechin (2), myricitrin (3), epicatechin-3-O-gallate (4), avicularin (5), quercitrin (6), and juglanin (7) based on the analysis of the 1H-NMR, 13C-NMR and ESI-MS data. All compounds exhibited significant antioxidant activity on DPPH assay and active compounds were well correlated with predicted one.
돼지 난자의 체외성숙에서 합성배양액에 첨가된 과당이 난자의 성숙 및 단위발생 배아의 체외발육에 미치는 영향
신혜지,김민지,이주형,이승태,박춘근,현상환,이은송 한국수정란이식학회 2017 한국동물생명공학회지 Vol.32 No.3
The objective of this study was to determine the effect of fructose that was supplemented to a chemically defined in Vitro maturation (IVM) medium on oocyte maturation and embryonic development after parthenogenesis in pigs. The base medium for in Vitro maturation (IVM) was porcine zygote medium (PZM) that was supplemented with 0.05% (w/v) polyvinyl alcohol (PVA) or 10% (v/v) porcine follicular fluid (pFF). In the first experiment, when immature pig oocytes were matured in a chemically defined medium that was supplemented with 5.5 mM glucose or with 1.5, 3.0 and 5.5 mM fructose, 3.0 mM fructose resulted in a higher nuclear maturation (91.5%) than 1.5 and 5.5 mM fructose (81.9 and 81.9%, respectively) but showed a similar result with 5.5 mM glucose (94.2%). However, there was no significant differences among groups in the embryo cleavage (89.4-92.4%), blastocyst formation (37.5-41.1%), and mean cell number of blastocyst (30.8-34.2 cells). Fructose at the concentration of 3.0 mM (1.08 pixels/oocyte) resulted in a higher intra-oocyte glutathione (GSH) content than 1.5 and 5.5 mM fructose (1.00 and 0.87 pixels/oocytes, respectively) while the cumulus cell expansion was not influenced. In the second experiment, effect of individual and combined supplementation of a chemically defined maturation medium with 5.5 mM glucose or 3.0 mM fructose was examined. No significant effect was found in the nuclear maturation (86.3-92.6%). Embryo cleavage was significantly increased by the combined supplementation with glucose and fructose (95.2%) compared to that with 3.0 mM fructose only (85.7%) while blastocyst formation (37.3-42.8%) and embryonic cell number (33.3-34.1 cells) were not altered. Effect of supplementation of pFF-containing medium with glucose and fructose + glucose was examined in the third experiment. No significant effect by the supplementation with glucose and fructose or glucose alone was observed in the nuclear maturation of oocytes (90.7-94.1%) and blastocyst formation (51.0-56.5%). Our results demonstrate that 3.0 mM fructose was comparable to 5.5 mM glucose in supporting in Vitro oocyte maturation and embryonic development after parthenogenesis and could be used as an alternative energy source to glucose for in Vitro maturation of pig oocytes.
안면 비대칭을 동반한 골격성 I급 환자의 수술교정 치험례
신혜지,한영집,홍미희,경희문 대한치과교정학회 2020 대한치과교정학회 임상저널 Vol.10 No.4
The purpose of this case report was to describe the considerations in surgical orthodontic treatment of a patient with skeletal Class I malocclusion and facial asymmetry. A 22-year-old male presented with a chief complaint of facial asymmetry. Clinical examination showed severe facial asymmetry to the right side at his chin point. Also he showed lip canting and straight facial profile. Intraorally, he exhibited posterior crossbite in the right side with severe mandibular dental midline deviation to the right. After presurgical orthodontic treatment with dental decompensation was done, sagittal split ramus osteotomy (SSRO) with mandibular body shaving was done to correct the mandibular asymmetry. After orthodontic treatment, posterior crossbite and midline of the dentition was corrected, and asymmetry of the mandible was improved. For the patient with facial asymmetry, it is critical to eliminate dental compensation orthodontically and to move the teeth to their proper positions to avoid relapse and obtain stability.
문화인지를 통한 국립한글박물관의 체험전시 평가 연구 - 외국인 경험요소를 중심으로 -
신혜리,김보연 커뮤니케이션디자인학회(구 시각디자인학회) 2020 커뮤니케이션 디자인학연구 Vol.71 No.-
21세기에 들어 박물관은 문화적 경험을 겪을 수 있는 중요한 영역이 되었으나 외국인들은 겪는 언어적 한계점과 타문화 문화 배경을 가지고 있기에 경험 전시가 내국인과 다를 수밖에 없다. 시대가 바뀜에 따라 다감각적 상호작용을 할 수 있는 경험을 더 중요시하며 이에 기반을 둔 체험전시의 중요도가 높아져 가고 있으나, 아직 국립한글박물관의 전시 및 체험방식을 위한 연구 및 전시연출이 미흡한 상태이다. 이에 본 연구의 목적은 첫 번째로 외국인 관광객을 위한 체험전시의 방법을 제시하고, 두 번째로 체험전시의 외국인 경험요소를 평가하고 개선하는 방향성을 고찰하는 것이다. 연구 방법은 첫째, 외국인의 습득 문화와 경험 디자인을 접목해 체험전시에 구성요인이 어떻게 나뉘는지 알아볼 것이며, 둘째, 문화인지를 고려한 경험요소를 통해 만들어진 분석프레임을 통해 국립한글박물관의 전시를 평가하며, 셋째, 국립한글박물관의 체험전시 콘텐츠를 평가하되 상설전시 중인 '한글로 가는 길'로 평가를 제한하며 현황을 파악한다. 결과적으로 외국인의 경험요소는 문화인지 특성을 통해 체험전시 연출을 통한 분석프레임으로 평가한 결과, 국립한글박물관의 체험전시는 유물을 시각적으로 보며 정보를 습득하는 데에 집중을 주어 다른 문화인지 경험요소들이 공간에서 강화가 필요하다. 이를 토대로 하여 문화인지와 경험디자인을 이용한 체험전시 분석을 토대로 체험전시를 평가하였으며 향후 전시에서 외국인들의 경험의 해석을 더 확대시키고 극대화 시킬 수 있음을 바란다. In 21st century, museums have become an important area to experience cultural experiences, but they have language limitations and cultural backgrounds. Purposes of this study are: to propose a method of experience exhibition for tourists, and to evaluate the foreign experience elements of the experience exhibition and consider the direction. For a method of this study, we will find out how the components divides into experience exhibitions by incorporating the culture and experience design of foreigners, an exhibition through an analysis frame that takes into account whether it is a culture and the contents of an exhibition at the National Hangeul Museum, but limit the evaluation to a permanent exhibition in the National Hangeul Museum. As a result, the experience elements of foreigners need to strengthen in space by focusing on visualizing artifacts and learning information, according to the analysis frame through the characteristics of culture and exhibition. Based on the analysis of the experience exhibition using cultural awareness and experience design, we hope that the exhibition will be able to further expand and maximize the interpretation of foreigners' experiences in future exhibitions.