오령산의 피오글리타존 부작용 경감 효과

신은정,최한별,한은정,정성현,Shin, Eun-Jung,Choi, Han-Byul,Han, Eun-Jung,Chung, Sung-Hyun 대한약학회 2007 약학회지 Vol.51 No.5

Thiazolidinediones (TZDs) induce insulin sensitization through the activation of PPAR${\gamma}$. However, the undesirable effect such as weight gain was observed. The purpose of this study was to find out an herbal drug that could reduce the side effects of pioglitazone. Among herbal formula that we have searched, oryung-san (OR) inhibited the differentiation of preadipocytes and did not affect on glucose uptake in 3T3-L1 adipocytes. In vitro, glucose uptake assay and Oil Red-O staining in 3T3-L1 adipocytes were conducted. In vivo, pioglitazone (PIO, 30 mg/kg), oryung-san (OR, 300 mg/kg), or pioglitazone co-administered with oryung-san (PIO+OR) were administered orally for 7 weeks in high fat diet (HFD) fed ICR mice and measured the body weight and blood glucose level every week. PIO+OR group significantly reduced body weight gain, triglyceride, and total cholesterol compared to PIO group. In addition, PIO+OR group showed a significant reduction of plasma glucose level (72%) compared to HFD control group. Insulin levels in PIO+OR group was also markedly decreased by 85% and 41% compared to HFD control and PIO group, respectively. Diameter of white adipocytes was decreased in the PIO+OR group compared to that in PIO group. Moreover, PIO+OR group reduced expression of PPAR${\gamma}$ and SREBP1a compared to PIO group. Taken together, oryung-san can improve side effects of pioglitazone, such as weight gain and edema, and shows a synergistic effect in plasma insulin levels.

상가권리금의 가치형성요인에 관한 연구

신은정,유선종,김명기,Shin, Eun-Jung,Yoo, Seon-Jong,Kim, Myeong-Gi 한국국토정보공사 공간정보연구원 2017 지적과 국토정보 Vol.47 No.1

In this study, collecting data in real retail-premium market and the influencing factors were extracted explored the formation of retail-premium. This should identify the level of retail-premium through an objective estimate of expenses, revenues, etc. A hierarchical regression analysis was conducted focusing on how the operating profit affected the formation of retail-premium. Store operators will have to be accompanied by the management of the operating profit to keep the initial payment and in order to receive a raise retail-premium. Through this process, It is possible to prevent the gap between retail-premium calculated through the appraisal and market practices. Ultimately, I believe and achieve the objective, transparent, the advancement of retail-premium market. 본 연구에서는 상가권리금의 가치에 영향을 미치는 요인에 관하여 고찰하고 영향의 정도를 분석하기 위하여 실제 권리금 거래 자료를 바탕으로 연구를 진행하였다. 특히 영업이익이 권리금의 형성과정에 어떠한 영향을 미치는지를 중심으로 분석을 진행하였다. 위계적 회귀분석결과 상가권리금에 가장 큰 영향을 미치는 독립변수는 월영업이익이었으며, 두 번째로 영향이 큰 변수는 월환산임대료로 나타나 권리금의 형성은 영업이익의 크기에 의하여 주로 결정되는 것을 확인할 수 있었다. 이러한 결과를 토대로 권리금을 지불하고 점포를 임차하는 경우 매출, 제반 비용 등에 대한 객관적인 추정을 통해서 권리금수준을 파악해야 할 것으로 사료된다. 또한 점포 운영자는 당초 지급한 권리금을 유지하고 상향된 권리금을 수수하기 위해서는 영업이익의 관리가 수반되어야 할 것이다. 법제화 이후 상가권리금 제도의 안정적인 정착을 위해서는 권리금에 대한 인식의 대전환이 필요한 시점이다. 이를 통하여 시장관행상 형성된 권리금과 감정평가를 통해 산정한 권리금과의 괴리를 방지하고 권리금 시장이 객관화, 투명화, 선진화되기를 기대한다.

플라즈마분자선에피탁시법을 이용한 C-면 사파이어 기판 위질화인듐갈륨박막의 에피탁시 성장

신은정,임동석,임세환,한석규,이효성,홍순구,정명호,이정용,Shin, Eun-Jung,Lim, Dong-Seok,Lim, Se-Hwan,Han, Seok-Kyu,Lee, Hyo-Sung,Hong, Soon-Ku,Joeng, Myoung-Ho,Lee, Jeong-Yong,Yao, Takafumi 한국재료학회 2012 한국재료학회지 Vol.22 No.4

We report plasma-assisted molecular beam epitaxy of $In_XGa_{1-X}N$ films on c-plane sapphire substrates. Prior to the growth of $In_XGa_{1-X}N$ films, GaN film was grown on the nitride c-plane sapphire substrate by two-dimensional (2D) growth mode. For the growth of GaN, Ga flux of $3.7{\times}10^{-8}$ torr as a beam equivalent pressure (BEP) and a plasma power of 150 W with a nitrogen flow rate of 0.76 sccm were fixed. The growth of 2D GaN growth was confirmed by $in-situ$ reflection high-energy electron diffraction (RHEED) by observing a streaky RHEED pattern with a strong specular spot. InN films showed lower growth rates even with the same growth conditions (same growth temperature, same plasma condition, and same BEP value of III element) than those of GaN films. It was observed that the growth rate of GaN is 1.7 times higher than that of InN, which is probably caused by the higher vapor pressure of In. For the growth of $In_xGa_{1-x}N$ films with different In compositions, total III-element flux (Ga plus In BEPs) was set to $3.7{\times}10^{-8}$ torr, which was the BEP value for the 2D growth of GaN. The In compositions of the $In_xGa_{1-x}N$ films were determined to be 28, 41, 45, and 53% based on the peak position of (0002) reflection in x-ray ${\theta}-2{\theta}$ measurements. The growth of $In_xGa_{1-x}N$ films did not show a streaky RHEED pattern but showed spotty patterns with weak streaky lines. This means that the net sticking coefficients of In and Ga, considered based on the growth rates of GaN and InN, are not the only factor governing the growth mode; another factor such as migration velocity should be considered. The sample with an In composition of 41% showed the lowest full width at half maximum value of 0.20 degree from the x-ray (0002) omega rocking curve measurements and the lowest root mean square roughness value of 0.71 nm.

비석(碑石)에 칠해진 주사(朱砂)안료에 관한 연구

신은정,한민수,강대일,Shin, Eun-Jung,Han, Min-Su,Kang, Dai-Il 국립문화재연구원 2005 헤리티지:역사와 과학 Vol.38 No.-

우리나라에서 고대에 사용하던 붉은 색 안료에는 주사, 석간주, 장단 등이 있다. 이중에서 주사는 고급스러운 상품(上品)으로써 벽사의 상징적 의미를 지니고 있어 단청, 벽화, 회화를 비롯해 비석, 지석 등에 다양하게 나타나고 있다. 특히 "공사견문록(公私見聞錄)"의 기록에서는 고려재상의 지석 음각에 붉은 칠을 메웠다고 기록되어 있어 비, 신도비, 지석 등에 주사와 같은 붉은 칠이 된 것은 고려시대 또는 그 이전부터라고 볼 수 있을 것이다. 문헌기록을 토대로 하여 비석에 남아있는 붉은 안료들의 몇 사례를 조사해 본 결과 대부분 주사, 장단, 석간주 등이 칠해졌음이 분석되었다. 또한 붉은 색의 발색을 더욱 선명히 하기 위해 붉은 칠 아래 바탕칠로써 호분칠이 된 경우도 발견되었다. 현존하는 붉은 안료가 칠해진 비석들은 대부분 조선시대 이후의 사례들이므로 조선시대에는 비등에 붉은 안료로 주사를 사용했음을 알 수 있었는데, "공사견문록(公私見聞錄)"에 남겨진 기록을 보아 고려시대에도 칠해졌음을 추정해 볼 수 있다. 또한 삼국시대 이미 주사안료가 중국으로부터 수입되어 우리나라에 고가의 상품으로 사용되던 역사적 배경을 살펴볼 때 비에 붉은 안료를 칠하던 것은 고려 이전부터 였을 가능성도 배제할 수 없다. 이렇게 붉은 안료로 주사를 주로 사용했을 것은 주사가 지닌 벽사적 상징의미를 미루어 볼 때 상당히 가능성이 있으며 당시 주사가 매우 고가인 탓에 한때 사용이 금지되기도 하였기에 주사 대신 석간주나 장단과 같은 대체안료가 사용되기도 했을 것으로 추정된다. Red ocher, red lead or cinnabar has been as red colorant for ages. Cinnabar of the red pigments has been highly regarded as a valuable ingredient because it represent a symbol of exorcising and a haute image. It was used as a pigment of painting and mural painting, bowl, clothes, rock writing, gravestone, etc. It is powder which dissolves in perilla oil or glue before using. Because it is high-priced, the use of cinnabar may be limited to the privileged class. Therefore, red ocher or red lead was used instead of cinnabar. "Gongsagyunmunrok" demonstrated that government official's gravestonea has been painted red by two colorants in the period of the Goryeo dynasty. However, cinnabar may be used to paint gravestones for the first time in the period of the Three States because it has been transmitted since the times. This study discuss the results obtained from an analysis of the pigments used on the red pigments of the Stone Monuments. The results can be briefly summarized as below; First, the microcrystalline structures seen on the surface section of analyzed pigments, samples of which were taken from various parts of red pigments show that different sizes and shapes of pigment particle. Second, a result of the analysis on the composition and structure of the pigments shows that the main components in their composition are : Red pigments - Red lead($Pb_3O_4$), Cinnabar(HgS) and Hematite($Fe_2O_3$) White pigments - Calcite($CaCO_3$) Especially, we knew that red Stone Monuments were found to be natural mineral pigments, which were used as a singular or a mixture.

대장균에서 분자 chaperone에 의한 alginate lyase의 가용성 발현 증대

신은정,이재형,박소림,김형락,남수완,Shin, Eun-Jung,Lee, Jae-Hyung,Park, So-Lim,Kim, Hyeung-Rak,Nam, Soo-Wa 한국생명과학회 2007 생명과학회지 Vol.17 No.1

E. coli에서 Pseudoalteromonas elyakovii 유래의 alginate lyase유전자(aly)를 발현시킬 때, 대부분의 단백질이 불용성 내포체 형태로 발현됨을 확인하였다. Alginate lyase를 가용성 활성형으로 생산하기 위해 aly와 DnaK/DnaJ/GrpE 또는 aly와 GroEL/ES을 공발현하는 형질전환체를 얻었다. 공발현 결과, 단백질의 올바른 접힘을 도와주는 DnaK/DnaJ/GrpE chaperone이 가용성 및 활성형의 alginate lyase 생산에 매우 효과적임을 알 수 있었다. DnaK/DnaJ/GrpE chaperone의 발현에 유도제인 L-arabinose 최적 농도는 0.05 mg/ml이었으며, 이러한 공발현에 의해 약 34%의 alginate lyase가 가용성 분획에서 생산되었다. 또한 10%의 cetylpyridinium chloride를 첨가함으로써, 공발현 콜로니 주위에 투명환이 형성됨을 확인할 수 있었고, 이는 활성형 alginate lyase 효소에 의해 alginate가 분해되었음을 시사하였다. When alginate lyase gene (aly) from Pseudoalteromonas elyakovii was expressed in E. coli, most of the gene product was produced as aggregated insoluble particles known as inclusion bodies. In order to produce a soluble and active form of alginate lyase, E. coli cells fore cotransformed with the plasmids designed to permit coexpression of aly together with molecular chaperones such as DnaK/DnaJ/GrpE or GroEL/ES chaperones. The results revealed that the coexpression of aly together with DnaK/DnaJ/GrpE chaperone had a marked effect on the production of this protein as a soluble and active form, presumably through facilitating correct folding of alginate lyase protein. The optimal concentration of L-arabinose for the induction of DnaK/DnaJ/GrpE chaperone was found to be 0.05 mg/ml. When DnaK/DnaJ/GrpE chaperone was coexpressed, about 34% in the total alginate lyase was produced in the soluble fraction. By addition of 10% cetylpyridinium chloride, a clear zone around the colony coexpressing aly and DnaK/DnaJ/GrpE chaperone was formed, indicating that the alginate in the medium was hydrolyzed by active alginate lyase enzyme.

기성품 바 어태치먼트 시스템인 SFI bar를 이용한 피개의치 전악수복 증례

신은정,주한성,방몽숙,양홍서,박상원,임현필,윤귀덕,Shin, Eun-Jung,Joo, Han-Sung,Vang, Mong-Sook,Yang, Hong-So,Park, Sang-Won,Lim, Hyun-Pil,Yun, Kwi-Dug 대한치과보철학회 2014 대한치과보철학회지 Vol.52 No.4

전통적인 바와 클립 유지형 피개의치의 경우, 인상채득 및 기공과정에서 오차가 생길 수 있어 바가 nonpassive fit하게 제작될 수 있다. 최근에 나온 기성품 바 어태치먼트 시스템인 SFI-Bar (Stress Free on Implant Bar) system (Cendres+Metaux, Biel/Bienne, Switzerland)은 튜브바로 연결하여 조립하는 방식이므로 밀링방식이나 캐스팅방식에서 겪을 수 있는 작업상의 많은 어려움과 긴 작업 시간의 단점을 보완 할 수 있고, 임플란트 주위골에 가해지는 스트레스도 줄여줄 수 있다. 본 증례에서는 골흡수가 심한 상악 무치악 환자에게 최근에 나온 stress free implant bar인 SFI-Bar system을 사용한 피개 의치로 수복하였다. SFI Bar를 이용한 피개의치 제작시 수동적 적합을 얻을 수 있어 임플란트에 스트레스를 덜 가하는 장점을 얻을 수 있을 것으로 생각한다. 추후 정기적인 검사를 통해 장기적인 결과에 대한 평가가 필요하리라 사료된다. In conventional bar- and clip-retained overdentures, all errors during impression making and cast fabrication result in non-passive fit of bars. SFI bar is prefabricated and assembled in the patient's mouth without the use of soldering, laser welding or conventional bonding techniques, thus reducing stress transmission to, bone loss around the implants and leading to fewer errors and lower costs. A clinical case will be presented below to demonstrate the use of the SFI Bar (Stress Free on Implant Bar) to restore an severe atrophy edentulous maxilla. In this case, no lateral stress could be applied to the implants due to the telescopic design of the bar joints. However, periodic recall check is necessary and long-term clinical results are required.

인스타그램에서의 페르소나와 패션을 통한 자기표현에 관한 연구 -20~30대 여성을 중심으로-

원연정 ( Yeon Jung Won ),신은정 ( Eun Jung Shin ),고애란 ( Ae-ran Koh ) 한국의류학회 2021 한국의류학회지 Vol.45 No.5

This study qualitatively explored the case of users utilizing multiple accounts on one social network service to create their own multiple spaces and different personas. The purpose of the study was to understand the behavior of people who use multiple accounts to express their identity online using Carl Jung's personality theory. We used in-depth interviews and the Zaltman metaphor elicitation technique (ZMET), targeting 19 people in their 20s and 30s who use more than one personal account on Instagram. Creating a shared consensus map using the configuration concept of ZMET derived six personas in relation to Instagram accounts. The motivations for the respondents' self-presentation associated with their personas and self-presentation types shown on Instagram were analyzed in terms of persona and fashion and subdivided into five dimensions: relationship management strategic presentation, self-monitoring presentation, competence demonstration presentation, anonymous presentation, and persona-centered presentation. Each respondent's persona and self-presentation formed by the Instagram account was analyzed.

콜라겐과 식초의 복합식이가 40-60대 여성의 손톱에 미치는 영향

신은정 ( Eun Jung Shin ),강상모 ( Sang Mo Kang ) 한국미용학회 2013 한국미용학회지 Vol.19 No.2

This study investigated the effect on improvement of nail, aimed at women in their 40 s, 50 s, 60 s who begun to suffer from aging and were expected to be in hypochlorhydria, and conducted a 12-weeks dietary experiment to 11 persons in each group, by categorizing into complex diet group of collagen+vinegar(C+V), single diet group of collagen(C), single diet group of vinegar(V) and control group(Cont). The results could be arranged as follows; Brightness in nail color of C+V group was shown to be most improved, Nail thickness of C+V group was shown to be increased 1.5 times that of C group. Nail density of C+V group was shown to be increased 1.9 times that of C group. Health of nail surface of C+V group was shown to be more improved for roughness and cracks compared to C group, V group. From above result, we found that Complex diet group of Collagen+Vinegar had a greater effect on improvement of nail than Single diet group of Collagen or Vinegar respectively, putting women in their 40 s, 50 s, 60 s into object.

콜라겐과 난백 및 식초의 복합식이가 혈액 성분 및 손톱의 아미노산에 미치는 영향

신은정 ( Eun Jung Shin ),강상모 ( Sang Mo Kang ) 한국미용학회 2012 한국미용학회지 Vol.18 No.4

This study was performed to examined the variation of contents of collagen, albumin, ferritin in blood and the change of amino acid content of nails of female adults, aged 40 to 60 who presumed to be hypochlorhydria and to be easily broken in their finger nails because aging began. This study was conducted for 12 weeks dietary experiment to 11 people in each group by categorizing into Complex Diet group of Collagen+Egg White+Vinegar, Single Diet group of Collagen+Egg White+Vinegar. The results showed that Complex Diet group of Collagen+Egg White+Vinegar(C+EW+V), increased 5.7 times more increased variation of collagen level in blood of Collagen(C) group, 1.2 times of Collagen+Vinegar(C+V) group, 8.1 times that of Egg White(EW) group, 3.0 times that of Collagen+ Egg White(C+EW) group, and 1.3 times that of Egg White+Vinegar(EW+V) group. As for a albumin level and ferritin levels in blood, Complex Diet group of Collagen+Egg White+Vinegar(C+EW+V) was the highest. The results showed that Complex Diet group of Collagen+Egg White+Vinegar (C+EW+V) increased 3.3 times increased variation of nail amino acid of Collagen(C) group, 1.7 times that of Collagen+Vinegar group(C+V), 3.8 times that of Egg White(EW) group, 2.7 times that of Collagen+Egg White group(C+EW), and 2.1 times that of Egg White+Vinegar group(EW+V), which found that increased amount of amino acid in Complex Diet group of Collagen+Egg White+Vinegar(C+EW+V) was the most.

여고생들의 피부건강관리에 대한 지식, 태도 및 실천행위

신은정 ( Eun Jung Shin ),전만중 ( Man Joong Jeon ),사공준 ( Joon Sakong ) 한국미용학회 2009 한국미용학회지 Vol.15 No.1

The knowledge, attitude and practice on skin health care were investigated among 200 high school girls at the girl`s high school in Yeongcheon city to provide proper skin care information and methods of actual skin care by using the structured questionnaire. The average score on knowledge of skin health care was 6.08 points(out of 14 points). It was not significantly different according to the characteristics including the student`s grade, economic status and level of mother`s education. However, it was significantly different higher among those girls having no older sisters(p<0.01), among those girls having very much interest of overall health(p<0.05) and the highest among those girls who obtain information about skin care management through the mass media(p<0.01). The average score on the attitude toward skin care management was 4.02 points(out of 11 points). It was significantly higher among those girls having no older sisters(p<0.01), among those girls whose mother`s level of education was high school(p<0.01), among those girls who had more than 60,000 won of monthly allowance(p<0.01) and among those girls who were interested in health(p<0.01). The average score of practice on skin care management was 2.98 points(out of 12 points). It was significantly higher among those girls from well-to-do families(p<0.05), among those girls having no older sisters(p<0.01), among those girls who were thought to be health(p<0.01), among those girls who were more interested in health(p<0.01), among those girls who were satisfied with external aspect and skin condition(p<0.01), and the highest among those girls who obtain skin care information from dermatology clinics and private skin care clinics(p<0.01). In conclusion, the levels of knowledge, attitude, and actual skin care were high among those girls having no older sisters, and among those girls who were interested in health. Therefore, it is suggested that education of skin health is needed with health education at school. Since there were many subjects who obtained information about skin care management through the mass media, education of skin health is needed at school to deliver correct skin care information and to let the students practice proper skin care.