http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
라미부딘 내성이 발생한 만성 B형간염에서 아데포비어에 대한 초기 치료 반응이 아데포비어 내성 발생에 미치는 영향
김인희 ( In Hee Kim ),김성훈 ( Seong Hun Kim ),김현철 ( Hyun Chul Kim ),신경덕 ( Kyoung Deok Shin ),김상욱 ( Sang Wook Kim ),이승옥 ( Seong Ok Lee ),이수택 ( Soo Teik Lee ),김대곤 ( Dae Ghon Kim ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3
기능성 소화불량 및 활동성 십이지장궤양에서 Omeprazole을 포함하는 Helicobacter pylori 박멸제를 이용한 치료효과
신경덕,서재석,이수택,김대곤,안득수 의과학연구소 1999 全北醫大論文集 Vol.23 No.2
Background and objectives : H. pylari has been known important cause of functional dyspepsia and duodenal ulcer. It was reported that duodenal ulcer and functional dyspepsia were improved after eradication of H. phlori. Combination therapy of proton pump inhibitor and two antibiotics(clarithromycin, nitroimidazole or amoxicillin) was recommended. This study was performed to compare the effectiveness of three different regimens in patients with H. pylori. Methods : We performed three tests including endoscopipc biopsy, urea breath test, rapid urease test, before the start of treatment in 15 patients of functional dyspepsia and duodenal ulcer. Drugs of different triple therapy regimen were administered to each pattient randomly for 1 week. The enrolled patients were assigned to one of three treatment schedules. Group Ⅰ : omeprazole 20 ㎎ bid, amosicillin 1,000㎎ bid, clarithromycin 500 ㎎ bid, Group Ⅱ : omeprazole 20 ㎎ bid, clarithromycin 500㎎ bid. And, omeprazole single dose of 20㎎ was administered to all patients for 2 weeks. Urea breath test and rapid urease test were performed to all patients repeatedly through gastrofiberscopy after treatment of two weeks. Results : Fifteen patients with active duodenal ulcer were cured completely by very short term therapy with omeprazole, combination of antibiotics such as tinidazole, clarithromycin, amoxicillin. There were no significant differences in effects and eradication rate of three different treatment regiment including low dose clarithromycin. The eradication rate of three regimens were 80%, 90.9%, 100%, respectively. Symptoms of patients with functional dyspepsia were improved significantly. Adverse effects such as bitter sensation, abdominal discomfort, constipation, diarrhea, dizziness, headache occurred during treatment. But no patient stopped treatment because of any adverse effect. We had done endoscopy as follow-up after 6 months of treatment. No patients have recurred. Conclusions : Active duodenal ulcer could be cured by three weeks regimen completely. Three different triple combinatio therapy containing proton pump inhibitor was effective and safe. But further large scale long term follow-up study is needed to evaluate the reactivation or reinfection of H. pylori.
두가지 형태의 스테인레스 스틸 풍선확장형 관동맥 튜브스텐트를 경험한 단일 병원에서의 임상결과 비교 연구
채제건,신경덕,김현철,이병현,이수택,김원호,고재기 의과학연구소 2000 全北醫大論文集 Vol.24 No.1
Background and Objectives : Since the introduction of Palmaz-Schatz stent, various second generation stainless steel ballon-expandable tube stents such as MultiLink or NIR stents have been developed and used in the field of coronary intervention. The initial results of these stents were comparable to or even better than those of Palmaz-Schatz stent. However, the clinical and angiographic results comparing with these second generation stents have not been known yet. The purpose of this study was to evaluate the initial and late outcomes of these second-generation tube stents in the experiences of the single institution. Materials and Method : We retrospectively analyzed the efficacy of MultiLink or NIR stents which had been implanted for elective stenting in 140 patients with 155 de novo lesions. Patients with the multiple stents in a single lesion were excluded. There was no limitation of the clinical presentations. Group 1 included the patients who underwent the implantation of short MultiLink 15mm, Group 2 included also the similar length of NIR stent 9mm/16mm. The patients who underwent the implantation of intermediate length of MultiLink 25mm/35mm were group 3, NIR 25(26)mm/32mm was underwent the implantation of intermediate length of MultiLink 25mm/35mm were group3, NIR 25(26)mm/32mm was group 4. Repeat coronary angiography was performed at 187±59 days after stenting with quantitative coronary angiographic analysis (QCA). Results : There were no sgnificant differences in any baseline clinical and angiographic variables between each groups. The mean procedural success rates were 85% and similar in all groups. During the follow-up periods, there were no subacute stent thrombosis, re-infarcrion and death in all groups. Each restenosis rate was 26%, 23%, 14% and 27% and each target lesion revascularization (TLR) rate was 15.0%, 4.7%, 6.7% and 9.5% in group 1, 2, 3 and 4, respectively. These results exhibited that short MultiLink group showed higher TLP rate than short NIR group (p<0.05). Conclusion : There were no sgnificant differences in immediate or midterm clinical and angiographic outcomes after the implantation of MultiLink or NIR stents, which have different designs of stainless-steel ballon expandable tube type except higher TLR rate in short MultiLink than short NIR stents. The midterm outcomes of intermediate length of two tubular stents were similar with those of short stents. However, more experiences and futher evaluations should be warranted.
경피적 알코올 중격절제술로 치료한 비후성 폐쇄성 심근병증 1예
고재기,신경덕,채제건 의과학연구소 1999 全北醫大論文集 Vol.23 No.1
특발성 비후성 심근병증은 좌심실 유출로의 역동적 폐쇄와 대동맥판막하 심실중격의 비대칭성비후를 특징으로 하는 질환이며 지금까지 베타차단제나 칼슘길항제를 이용한 약물요법과 영구형 심박동기를 설치하는 방법, 수술적인 방법이 이용되어 왔다. 저자들은 100% 알코올을 이용하여 비수술적 방법인 경피적 알코올 중격절제술을 시행함으로써 좌심실 유출로의 폐쇄와 압력차를 효과적으로 감소시킨 비후성 폐쇄성 심근병증 환자 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
전혈을 이용한 BiocardTM Helicobacter pylori IgG One-step Immunochromatographic Test 의 유용성
안득수,이수택,이흥범,신경덕,채제건 대한소화기학회 1999 대한소화기학회지 Vol.34 No.3
Background/Aims: The aim of this study was to evaluate usefulness of whole blood serologic test (BiocardTM H. pylori IgG one-step immunochromatographic test) in detecting IgG antibodies to Helicobacter pylori (H. pylori). Methods: For patients with dyspepsia and abdominal discomfort, gastroduodenoscopy was performed. We excluded patients who received treatments for H. pylori infection within a year or who took drugs such bismuth compounds, proton pump inhibitors, or antibiotics (metronidazole, amoxicilline, tetracycline) within 2 weeks. During gastroduodenoscopy, specimens were obtained from the antrum for rapid urease test and histologic examination (Hematoxyline-eosin stain, Giemsa stain). Biocard H. pylori test was performed using whole blood. Characteristics of the Biocard test were evaluated using Giemsa stain and rapid urease test as the $quot;gold standard.$quot; Results: Biocard test was carried out immediately after the endoscopic examination, and the result was available within 10 min in all cases. When the Biocard H. pylori test was compared with histology or rapid urease test, the sensitivity and specificity were 92.8% and 71.3%, respectively. Moreover, its positive predictive value was 92.8% and the negative predictive value was 71.3%. Conclusions: The Biocard H. pylori test using whole blood sample was an easy and rapid method and yielded relatively good performance. This test can be an accurate screening method for H. pylori infection in the office setting and primary care units.
김형식,안득수,김대곤,신경덕,이제경 대한소화기학회 1999 대한소화기학회지 Vol.34 No.2
Background/Aims: We determined whether the portal hypertension in patients with esophageal varices would be changed hemodynamically after endoscopic injection sclerotherapy (EIS). Present study was performed to find out hemodynamic change of portal hypertension, the occurrence of new gastric varix and the disappearance of previous gastric varix after EIS. Methods: The doppler sonographic parameters including cross sectional area, velocity of flow, blood flow volume, and congestion index were used to measure the portal hemodynamic change between before and after EIS in 22 patients. Additionally, gastrofiberscopic examination was performed to determine the effects of EIS on gastric varix formation before and a year after EIS. Results: Four parameters of doppler ultrasound were not significantly changed between before and after EIS, while the blood flow volume increased. One cases (67%) revealed newly formed gastric varix, but 3 out of 7 cases (43%, p=0.022) in which the early endoscopic examination identified the presence of gastric varix showed a decrease of it. Conclusions: In patients with esophageal varices, hemodynamics was not significantly changed after EIS. Moreover, gastric varix was not aggravated and even disappeared after EIS. Thus, EIS is supposed to be a positive therapeutic modality for treating esophageal varix.
만성 췌장염에 의한 가성동맥류 파열의 경도관 색전술을 통한 성공적 치료 1예
장재호,한영민,김형식,오상미,문병식,김광훈,신경덕,이수택,안득수,김대곤 대한소화기학회 1998 대한소화기학회지 Vol.31 No.4
Rupture of pseudoaneurysm from chronic pancreatitis is rare, but a fatal complication is encountered in patients with chronic pancreatitis. Tirnely diagnosis and treatment result in markedly reduced mortality. Surgery has been known as the established treatment for patients with chronic pancreatitis having pseudoaneurysmal rupture. Transcatheter embolization technique has also been regarded recently as one of the methods to avoid and decrease the surgical risk in such an emergency situation. An alcoholic 30-year-old man who had history of chronic pancreatitis with pseudocyst complained of fatigue and right upper quadrant pain. Celiac angiograpy revealed outpouching sac in the gastroduodenal artery. Thus, we performed embolization of the neck of the sac with steel coil successfully. After the embolization, subsidence of the symptoms was observed, Six months later, we checked abdominal CT. The pseudoaneurysm disappeared and surrounding hematorna was absorbed completely.