http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Clinical Significance of Dense Fine Speckled Pattern: Association with Inflammatory State
신강수,박민승,조은혜,박효순,권민정,이미연,우희연 대한진단검사의학회 2024 Laboratory Medicine Online Vol.14 No.1
배경: 29개의 항핵항체 형광양상 중 dense fine speckled (DFS) 양상의 임상적 의미는 불분명하다. DFS 양상은 건강한 정상인뿐만 아니라 다양한 환자에게서 검출되며, 염증성 미세환경의 지표가 될 수 있다고 보고되었다. 본 연구에서는 DFS 양상과 염증 표지자 및 다양한 질환과의 연관성을 분석하였다. 방법: 2019년부터 2022년 사이의 기간에 일개 3차 병원의 건강검진 또는 외래에서 ANA 검사가 의뢰된 862명(DFS 양성 436명, DFS 음성 426명)의 의료 정보를 수집하였다. 염증 표지자와 DFS 양성 사이의 연관성을 평가했고 로지스틱 회귀 모델을 사용하여 교란 변수를 조정한 오즈비(odds ratio)를 추정하였다. 결과: DFS 양성과 C-반응성 단백질(CRP), 백혈구 수, 호중구 비율과 같은 염증 표지자 사이에 유의한 연관성이 관찰되었다. 그러나 알레르기 비염만 DFS 양성과 유의한 연관을 보인 반면, 다른 염증성 질환들은 DFS 음성과 유의한 연관성을 보였다. 항 Ro/SSA 항체 및 항 La/SSB 항체와 DFS 양성과의 유의한 관련성은 주목할만했다. 결론: CRP, 백혈구 수, 호중구 비율과 같은 염증 표지자가 DFS 양성과 유의하게 관련이 있었지만, 염증 상태와 DFS 양성 사이의 연관성이 있다고 결론을 도출하기에는 부족했다. Background: The clinical significance of the nuclear dense fine speckled (DFS) pattern is unclear among 29 antinuclear antibody (ANA) patterns. DFS pattern has been reported in healthy individuals and in various patients, and is proposed to be an indicator of a proinflammatory microenvironment. We analyzed the association of DFS pattern with inflammatory markers and various diseases. Methods: Medical information was collected for 862 subjects (436 DFS-positive and 426 DFS-negative subjects) who were tested for ANA in regular health checkups or at the outpatient clinic at a tertiary hospital between 2019 and 2022. Statistical analyses were performed to assess the association between inflammatory markers and DFS positivity, and logistic regression models were used to estimate the odds ratios (ORs) adjusted for confounding factors. Results: A significant association was observed between the DFS positivity and inflammatory markers such as C-reactive protein (CRP) levels, white blood cell (WBC) counts, and proportions of neutrophils. However, only allergic rhinitis showed a significant association with DFS positivity, whereas other inflammatory-based diseases were significantly associated with negative DFS patterns. The significant relation of anti-Ro/SSA and anti-La/SSB antibodies with DFS positivity was remarkable. Conclusions: Although inflammatory markers such as CRP levels, WBC counts, and proportions of neutrophils were significantly associated with DFS positivity, the link between inflammatory states and DFS positivity remains controversial.
Oroantral Fistula의 이차적 폐쇄에 대한 치험례
김성권,신강수 朝鮮大學校 口腔生物學硏究所 1990 口腔生物學硏究 Vol.14 No.-
When the primary repair of an oroantral fistula fails to heal spontaneously during the first three weeks postoperatively a second repair may be indicated. Secondary repair of oroantral fistula is one of the more challenging and difficult problems in the field of oral and maxillofacial surgery. Numerous techniques have been recommended for the closure of these communications, most of which share an equal degree of success and failure. This article presents a technique using the connective tissue under the palatal mucosa ; results have been satisfactory in all 4 patients treated.
Liver Fibrosis Biomarker Validation Using Machine Learning Algorithms
김민경,권현주,신강수,박효순,우희연,박창훈,권민정 대한진단검사의학회 2023 Laboratory Medicine Online Vol.13 No.3
Background: Liver fibrosis which causes several liver diseases, requires early screening and management. The gold standard for fibrosis assessment, liver biopsy, has recently been replaced by noninvasive scores. In this study, we validated liver fibrosis-associated biomarkers using machine learning techniques applied in medical research and evaluated their prediction models. Methods: Noninvasive scores were assayed in 144 patients who underwent transient elastography (TE). The patients were divided into three groups (<7 kPa, 7–10 kPa, ≥10 kPa) according to their TE results. Feature selection and modeling for predicting liver fibrosis were performed using random forest (RF) and support vector machine (SVM). Results: Considering the mean decrease in impurity, permutation importance, and multicollinear analysis, the important features for differentiating between the three groups were Mac-2 binding protein glycosylation isomer (M2BPGi), platelet count, and aspartate aminotransferase (AST). Using these features, the RF and SVM models showed equivalent or better performance than noninvasive scores. The sensitivities of RF and SVM models for predicting ≥7 kPa TE results were higher than noninvasive scores (83.3% and 90.0% vs. <80%, respectively). The sensitivity and specificity of RF and SVM models for ≥10 kPa TE result was 100%. Conclusions: We used machine learning techniques to verify the usefulness of established serological biomarkers (M2BPGi, PLT, and AST) that predict liver fibrosis. Conclusively, machine learning models showed better performance than noninvasive scores.
Bone book 을 이용한 하악골 탈구에 대한 치험례
여환호,김광진,신강수 朝鮮大學校 口腔生物學硏究所 1989 口腔生物學硏究 Vol.13 No.-
The longer the mandible remains dislocated, the more difficult is the management of the condition. Muscle relaxation and manipulation may reduce the dislocation after a few minutes or hours ; however, the passage of time brings more severe muscle spasm and fibrotic preauticular changes, increasing the problem. Manual reposition is not possiblem anymore in most cases. Most of the reported case of prolonged dislocation have been treated surgically. The following report discusses a case of anterior dislocation of the mandible of five months' duration that was treated successfully by the conservative method using the bone hook.
여환호,김광진,신강수 朝鮮大學校 口腔生物學硏究所 1990 口腔生物學硏究 Vol.14 No.-
This is a case report of asymmetrical mandibular porgnathism with TMJ disorder. A patient, who had been sufferring from the maticatory difficulties resulting from the significant malocclusion with posterior cross bite and the facial disfigurement due to asymmetrical mandibular prognathism, visited to our Dept. for further evaluation and definitive treatment. About TMJ problem, the conservative treatment such as occlusal splint, myo-therapy, and orthodontic treatment was done preoperatively, and the orthognathic surgery was followed by means of sagittal split ramus osteotomy on the right side and vertical ramus osteotomy on the left side. In one year postoperatively, there were no significant complications such as compromised healing, poor segment position, malocclusion, and decreased function. The patient was satisfied with corrected dentofacial deformity an resolved TMJ disorder. The results are as follows: 1. This case was mandibular prognathism associated with TMJ disorder which was developed by the occlusal dysfunction and the emotional stress due to facial disfigurement. 2. In case of mandibular prognthism with TMJ disorder, the further cooperated studies of D/ oral and maxillofacial surgery, otrhodontics, and prosthetics were much necessary to achieve normal function after surgical repositioning of the jaws.