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송계용,한지윤,조윤화,임연순,서동혜,강현영 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.2
The papillary eccrine adenoma is a rare benign sweat gland neoplasm, first described by Rulon and Helwig in 1977. It is usually present as a solitary dermal nodule on the distal extremities. Histological examination revealed a well circumscribed, non capsulated dermal nodule consisting of multiple ducts with various size. These ducts were composed of double layered epithelial cells mostly and intraluminal papillation with eosinophilic luminal materials was seen. We report a case of papillary eecrine adenoma in 52-year-old male who presented single nodule on the right midback, uncommon area.
거대 우췌상 desmoplastic Spitz 모반 1예
송계용,이종육,박철종,양종규,현정선 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.5
Desmoplastic Spitz nevus is a distinct histological variant of Spitz nevus characterized by thick desmoplastic stroma, nevus cells with intranuclear invaginations of cytoplasmic material, and little or no junctional activity, nest formation and melanin pigment. We, herein, present a 40-year-old man with an asymptomatic, 1.7×1.5×0.9cm, dark brown to black verrucous tumor of a 2-year duration on his left earlobe, posterior aspect. Histopathologic examination shows thick desmoplastic stroma, nevus cells with intranuclear invaginations of cytoplasmic material, junctional activity, nest formation, and melanin pigment.
송계용,노병인,홍창권,김명남,천태종 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3
Lichen planus is a common dermatologic disorder involving the glabrous skin, hair bearing skin, scalp, nails, mucous membrane of the oral cavity, penis and vulva. We report a 28-year-old man with lichen planus occuring in both the oral and genital area. The oral lesion shows typical white lace-like patches and the genital lesion shows annular plaques.
송계용,한지윤,조윤화,서동혜,손호찬 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.1
Localized primary cutaneous amyloidosis consists of three types: nodular, macular, and lichenoid amyloidosis. Lichen amyloidosis is characterized by the appearance of paroxysmally itchy lichenoid papules on the shins. Although the origin of the amyloid is controversial and can not provide any definite answer, some of amyloid substances can be derived from epidermal cells and others from degenerative collagen fibers. We suggested the origin of amyloid in our cases as epidermal keratinocyte and collagen degenerations. Because degeneration of basal keratinocyte is observed on electron microscopy and degeneration of collagen is in H&E and Masson's trichrome stain although amyloid materials are negatively stained against pankeratin antibody and collagen antibody. The skin lesion was improved after triamcinolone intralesional injections which reduce collagen synthesis. We report two cases of lichen amyloidosis which stained negatively for antikeratin antibodies and improved with triamcinolone intralesional injection.
태아 및 성인의 간에서 Glutathione S-Transferase출현도에 관한 면역조직화학적 관찰
송계용,이윤덕,박상철 중앙대학교 의과대학 의과학연구소 1993 中央醫大誌 Vol.18 No.3
Both acidic placental form(GST-Pi) and basic liver form(GST-L ) of human glutathione S-transferase were studied in the developing, normal and abnormal livers using immunohistochemical peroxidase and antiperoxidase method. Time of appearance, temporal change of the activity and distribution pattern were particularly examined using 27 cases of human fetuses of ranging in age from 12 to 32 gestation weeks, 5 cases of normal infant as well as 12 cases of cirrhosis or carcinomas of the liver. The results were as follows; 1. Expression of the GST-Pi in the liver was weak in fetuses between 12 to 16 weeks but became conspicuous between 17 to 21 weeks and then it decreased to show weak posititivy between 24 to 32 weeks. The staining reaction was mild in childhood and adult livers. Meanwhile GST-L was stained weakly in fetuses between 12 to 13 weeks but became conspicuous from 14th week and of staining reaction was mild to moderate noted thereafter, in childhood and adult. 2. Expression of the GST-Pi in the bile ducts was weak in fetus between 12 to 16 weeks and became conspicuous in 17 to 24 weeks and stained strongly between 26 to 32 weeks and the strong of reaction was noted in childhood and adult intrahepatie bild ducts. GST-L was not demonstrated through the fetal period from 12 to 32 weeks but weakly positive in the large bile duct epithelium of childhood and adult. 3.Expression of the GST-Pi was the same degree of positivity as the normal in the hepatocytes and bile ducts adjacent to the hepatocellular carcinoma. GST-Pi showed moderately in the hepatocytes of regenerating nodule and adjacent proliferatinf bile ducts. It was weak to strong in trabe cular and acinar hepatocellular hepatoblastoma. Meanwhile, GST-L was of positive as the normal hepatocytes and bild ducts adjacent to the hepatocellular carcinoma of the liver. GST-L is weakly positive in regenerating nodule and weak to moderate in trabecular hepatocellular caricinoma, and negligible in acinar type. In conclusion, It was suggested that maturation and distribution pattern of GST-Pi and GST-L are significantly different between normal and neoplastic condition, and a possibility of dianostic application of isozymes of glutathione S-transferase in the differential diagnosis of neoplasms of hepatobiliary system could be raised.
송계용,김숙이,서중석,지제근 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
To observe the developing process of human fetal eccrine sweat gland during the intrauterine life, an electron microscopic study was carried out based on 12 fetuses ranging from 20 to 42 weeks of gestation. These fetuses were the products of induced deliveries found to have not associated disease or congenital anomalies at the autopsy. Following observations were made. The various types of cell consisting coiled portion of eccrine sweat gland were recognized at the 20th weed of gestation and they were clear cells, undifferentiated dard cells, myoepithelial cells. clear cells were located in central central portion and dark or myoepithelial cells were in peripheral portion. While undifferentiated dark cells were randomly distributed in the straight portion of eccrine sweat gland. The differential points between clear cell and undifferentiated dark cell were its round nucleus and glycogen contents. Marked hydropic changes of clear cells were noted at the 30th week of gestation. Secretory granules were noted at the 31st week of gestation. Secretory cells in the coiled portion of eccrine sweat gland was not fully mature until the 42nd week of gestation. Clear cells showed clear cytoplasm, abundant free ribosomes and scanty organelles. Undifferentiated dark cells showed many mitochondria and few glycogen. Secretory granules were rarely seen. Myoepithelial cells showed a few mitochondria, glycogen and microfilaments. Among three portions of eccrine gland, duct lumen in the acral and coiled portion were formed through the intracellular canaliculus and in the straight portion were made through the intercellular canaliculus. The main basic morphological mechanism of the lumen formation were microvesicle formation and pinched off phenomenon.