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유색미 겨 아라비녹실레인과 운동트레이닝이 Lipopolysaccharide 처치된 흰쥐의 면역인자 및 염증억제에 미치는 영향
손희정 ( Hee Jeong Son ),김형준 ( Hyung Jun Kim ),채정훈 ( Jeong Hoon Chae ),권형태 ( Hyung Tae Kwon ),여효성 ( Hyo Seong Yeo ),어수주 ( Su Ju Eo ),임예현 ( Yea Hyun Leem ),김효정 ( Hyo Jeong Kim ),김창근 ( Chang Keun Kim ) 한국응용생명화학회 2012 Journal of Applied Biological Chemistry (J. Appl. Vol.55 No.1
Arabinoxylan, Ara, rice bran has been shown to be a potent biological response modifier as manifested by stimulation of different arms of the immune system. We examined the effects of Ara rice bran and exercise on the immune function and cytokines in lipopolysaccharide (LPS)-stimulated rats. As the results, tumor necrosis factor-α as representative inflammatory cytokines showed a significantly lower in Ara supplement group, thus the Ara rice bran had a higher inhibitory activity than the both exercise and control group. However, 4 weeks of exercise training significantly increased inflammatory reactions rather than treatment with Ara in LPS-treated rats. The Ara rice bran acted to decrease the inflammatory reaction. These results suggest that the supplement of Ara rice bran is likely contribute to inflammation response and the Ara rice bran can be used as a possible safe alternative to the immunotherapeutic modalities.
인터렉션 디자인을 통한 교육정보 사이트 활용에 관한 연구
손희정(Hee Jung Son),전성복(Sung Bok Jun) 한국기초조형학회 2002 기초조형학연구 Vol.3 No.1
Today, with the rapid development of technology, the World Wide Web is gaining wider application limits. Also in educational fields, the recognition of the web`s practical usage is increasing. On the other hand, it is also true that we sometimes don`t get good results because of interfacial problems. These problems cause negative responses because they supply too much information and cause amusement. At this point, this research has found other useful factors by analyzing the ways in which interaction plays an important role for learners in achieving educational objectives especially in relation to the design field. Also, by developing these applied sites and by examining educational achievements through questioning, this writer made a concentrated argument for raising the educator`s participation in the Internet design field and allowing the highest degree of learning to be achieved.
이준행 ( Jun Haeng Lee ),김영호 ( Young Ho Kim ),현재근,성인경 ( In Kyung Sung ),손희정 ( Hee Jung Son ),이풍렬 ( Poong Lyul Rhee ),김재준 ( Jae J. Kim ),고광철 ( Kwang Cheol Koh ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chul Rhe 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
<목적> 대장선종에서 대장암으로서 진행과정에서 아포토시스는 감소되고 세포증식은 증가한다고 알려져 있다. 그런데 대장암에서 아포토시스와 세포증식의 상호관계나 병기에 따른 아포토시스나 세포증식의 변화양상에 대해서는 논란이 있어왔다. 본 연구에서는 각 병기에 따른 직장암 조직에서의 아포토시스와 세포증식의 정도를 정량적으로 관찰하고, 기존에 알려진 예후인자와 bcl-2 및 p53 의 발현과의 상관관계를 조사하였다. <방법> 수술로 절제된 57예의 직장암 조직을
무증상 성인에서 헬리코박터 파일로리 감염과 다양한 전신 염증 표지자의 연관성 결여
김태준 ( Tae Jun Kim ),표정의 ( Jeung Hui Pyo ),이혁 ( Hyuk Lee ),백선영 ( Sun-young Baek ),안수현 ( Soo Hyun Ahn ),민양원 ( Yang Won Min ),민병훈 ( Byung-hoon Min ),이준행 ( Jun Haeng Lee ),손희정 ( Hee Jung Son ),이풍렬 ( Poong 대한소화기학회 2018 대한소화기학회지 Vol.72 No.1
Background/Aims: Helicobacter pylori (H. pylori) infection has been known to cause various extra-gastric diseases, which may be mediated by an increase in systemic inflammation. Thus, we examined the association between H. pylori infection and various markers of systemic inflammation in a large sample of asymptomatic adults. Methods: Cross-sectional data were obtained from 17,028 adults who completed routine health check-ups. H. pylori infection status was determined using a serum immunoglobulin G test, and systemic inflammation was assessed using the C-reactive protein (CRP) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). Results: Multiple linear regression model-adjusted for potential confounders-revealed that H. pylori infection was not associated with CRP levels (coefficient: -0.012, 95% confidence interval [CI]: -0.037, 0.012, p=0.319), NLR (coefficient: 0.055, 95% CI: -0.027, 0.138, p=0.192), or PLR (coefficient: 1.798, 95% CI: -1.979, 5.574, p=0.351). In a multivariable logistic regression model, H. pylori infection was not associated with the risk of CRP levels being elevated to ≥0.1 mg/dL (odds ratio: 0.96, 95% CI: 0.81, 1.08) or ≥0.3 mg/dL (odds ratio: 1.02, 95% CI: 0.84, 1.19). In the multivariable model, CRP levels elevated to ≥0.1 mg/dL were significantly associated with body mass index, current smoking status, hypertension, and diabetes mellitus. Regular exercise and high-density lipoprotein cholesterol were factors that minimized the elevation of CRP levels. Conclusions: Chronic infection with H. pylori was not associated with various inflammatory markers. Further investigation is needed to clarify the interaction between H. pylori infection, systemic inflammation, and extra-gastric disease. (Korean J Gastroenterol 2018;72:21-27)
증례 : 비호지킨 림프종에서 리툭시맙 투여에 의한 간질성 폐질환 1예
최영준 ( Young Jun Choi ),정우진 ( Woo Jin Jung ),오세일 ( Se Il Oh ),전민혁 ( Min Hoyk Jeon ),손희정 ( Hee Jung Sohn ),한은미 ( Eun Mee Han ),서철원 ( Cheol Won Suh ) 대한내과학회 2006 대한내과학회지 Vol.71 No.4
리툭시맙은 CD20항원에 대한 단클론 항체로서 CD20을 발현하는 B세포계열의 비호지킨 림프종의 치료에 사용되어지고 있다. 리툭시맙 치료에 대한 부작용은 경증의 주입관련 이상 반응 외에 유의한 부작용은 없는 안전한 약으로 증명되었으나 최근들어 몇몇 환자에서 간질성 폐질환이 관찰되었다는 국외보고가 있었다. 저자들은 비호지킨 림프종 환자에서 리툭시맙에 의한 간질성 폐질환 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Rituximab targets CD20+ B cells and has been used increasingly for the treatment of B-cell Non-Hodgkin Lymphoma, alone or in combination with cytotoxic agents. Rituximab can kill CD20+cells by multiple mechanisms. Rituximab therapy has often been associated with an infusion-related symptom complex consisting of fever, chills, and rigors that is usually self-limited. These complications are transient without long-term effects. Several delayed pulmonary events involving interstitial reactions and bronchiolitis obliterans with organizing pneumonia have recently been described in conjunction with the use of Rituximab. In the lymphoma patient presented here there was no respiratory symptoms; however, respiratory difficulty developed after the third round of Rituximab plus CHOP chemotherapy. High resolution computed tomography (HRCT) and positive emission tomography (PET) were performed and revealed diffuse ground glass opacities. We report a patient with Non-Hodgkin Lymphoma in whom interstitial lung disease developed after Rituximab therapy.(Korean J Med 71:449-455, 2006)
기능성 소화불량증 환자에서의 Electronic Barostat을 이용한 위 팽창 반응에 관한 연구
이규택(Kyu Taek Lee),손희정(Hee Jung Son),이종균(Jong Kyun Lee),이준혁(Joon Hyeok Lee),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이종철(Jong Chull Rhee),노재형(Jae Hyung Noh),최성호(S 대한소화기학회 1997 대한소화기학회지 Vol.29 No.2
N/A Background/Aims: A decreased perception threshold of gastric distension has been observed recently in selected patients with functional dyspepsia(FD) in the absence of changes in gastric compliance. The sensations induced by changes in intragastric pressure and volumes have been shown to be independent of gastric emptying times. In Korea, there has been no report about the response to gastric distension using electronic barostat in patients with FD. Thus, we aimed to evaluate whether decreased perception threshold to the gastric distension could be one of the pathogenic factors in FD. Methods: Thirty patients with dysmotility-like FD(9 men and 21 women; age range, 27-57 years) and 20 healthy individuals without gastrointestinal symptorns(10 men and 10 women; age range, 20-54 years) were included in this study after receiving written informed consent. We measured intragastric minimal distending pressure(MDP), gastric compliance, aMominal discomfort level, and gastric emptying rate of solid meal. We used a dual drive barostat (G&J Electronics, Canada) and biad gamma camera(Trionix). MDP was defined as the first pressure level to inflate an intra gastric bag volume > 30mL. And then, symptoms and volume of the intragastric bag, which was inflated by increasing intragastric bag pressur, was measured in 1 mmHg steps every 3 minutes, We compared gastric compliance at a low pressure zone(0-2 mmHg above MDP) and at a high preassre zone(6-8mmHg above MDP), We calculated the mean values( SD) of the parameters, and statistical comparisons were performed using tbe repeated measures ANOVA. Results: The MDP was significantly decreased in FD(3.9>1.8 mmHg) compared to the controls(5.7+ 1.7 mmHg; p<0.001). The gastric compliance(Cw) at a high pressure zone was significantly higher in FD(46.5+30.6 mL/rnmHg) compared to the control(31.3 + 15.3 mL/mmHg; p<0.05). Whereas there was no difference in compliance(C) at the low pressure zone(41.2+25.6 mL/mmHg in FD vs. 43.9+23.1 mL/mmHg in the control). Patients with FD had gastric hypersensitivity to distension(discomfort threshold at 8.3+3.8 mmHg and 392+109 mL in FD vs. 14.S+3.8 mmHg and 558+135 rnL in controls; p<0.001). There were no differences in MDP, compliance, and discomfort level according to gastric emptying times. Conclusions: We conclude that decreased perception threshold to gastric distension could be a pathogenic factor, and also an increased gastric compliance at high pressure zone may play a pathogenic role in FD. (Korean J Gastroenterol 1997;29: 135 - 144)
장시간의 일회성 지구성 운동 수행 시 노화에 의한 쥐 골격근의 NF-ĸB 신호전달 변화
김형준(Kim Hyung-Jun),권형태(Kwon Hyeong-Tae),손희정(Son Hee-jung),채정훈(Chai Jung-Hoon),어수주(Eo Su-Ju),김창근(Kim Chang-Keun),김효정(Kim Hyo-Jung) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.3
Nuclear factor kappa B (NF- kB) is an important transcription factor of skeletal muscle atrophy. Several studies have been explored the possibile pathways which may be modulated with exercise and age. The purpose of this study was to examine the effect of one single bout of endurance exercise on nuclear factor kappa B (NF-kB) activation and MuRF1 expression in old rat. 32 rats were used and were divided into two groups by age; 20 weeks (n=16) vs 72 weeks (n=16). Each experimental group was further divided into two subgroups; Before exercise (n=8) and after exercise (n=8). All animals in exercise groups performed a 3 hr swimming exercise (30min x 6 bouts with 5min rest). Following the swimming exercise, the protein level of NF-kB (p65) subunit was increased in both old and young group(p<.05). The protein level of NF-kB (p65) was higher in old than young group before exercise (p<.05) and the expression of MuRF1 in only old group was increased with the swimming exercise(p<.05). On the other hand, In this study phospho-IkBa was unchnaged (p>.05). These results suggest that the expression of nuclear factor kappa B (NF- kB) with endurance exercise may a key role in muscle atrophy in aged group.
한국성인에서 S상결장경검사로 관찰된 대장 용종의 빈도와 특성
이화영(Hwa Young Lee),김재준(Jae Jun Kim),김영호(Young Ho Kim),성인경(In Kyung Sung),전성국(Seong Gook Jeon),손희정(Hee Jung Son),이풍렬(Poong Lyunl Rhee),고광철(Kwang Chul Koh),백승운(Seung Woon Paik),이종철(Jong Chul Rhee),오영륜(Y 대한내과학회 1998 대한내과학회지 Vol.55 No.1
N/A Objectives: Colorectal polyps play an integral role in the development of colon cancer. The prevalence of colorectal polyps in Korea was reported to be 5-12%. However, these results were obtained from retrospective studies, in which the subjects were symptomatic patients. Therefore, we performed a prospective study in asymptomatic Korean adults to determine the prevalence, characteristics, and risk factors of colorectal polyps. Methods Flexible sigmoidoscopy was done during the period between August 1994 to November 1995 in 2,985 aymptomatic individuals who visited Samsung Medical Center for health check-ups. Results : 1) Polyps were found in 590 subjects (20.4%) out of 2,985 individuals. The prevalence rate increased with age. 2) In histologic findings of colorectal polyps, there were 369 cases (45.8%) of adenomatous polyps, 245 cases (30.4%) of hyperplastic polyps and 5 cases of carcinomas. 3) Moderate to severe dysplasia was found in 15.4% of adenomatous polyps and the grade of dysplasia increased with polyp size. 4) The prevalence rate of polyps increased according to obesity, blood cholesterol and triglyceride level, the frequency of alcohol consumption and the amount of smoking in cases. Conclusions: Screening by sigmoidoscopy is considered to be beneficial for detection of colorectal polyps in asymptomatic Korean adults, especially in individuals with risk factors such as obesity, heavy smoking and alcohol consumption.