고빈도전침자극(高頻度電鍼刺戟)의 자극시간(刺戟時間)에 따른 중추신경계(中樞神經系) 신경세포(神經細胞)의 활성변화(活性變化)에 미치는 영향(影響)

손성세,남상수,이재동,최도영,안병철,박동석,이윤호,최용태,Sohn Sung-Sae,Nam Sang-Soo,Lee Jae-Dong,Choi Do-Young,Ahn Byoung-Choul,Park Dong-Seok,Lee Yun-Ho,Choi Yong-Tae 대한침구의학회 1998 대한침구의학회지 Vol.15 No.2

The present study was designed to investigate the effect of different stimulation-duration of high frequency electroacupuncturet(EA) treatment on the neuronal activities in the spinal cord and brainstem using Fos immunohistochemical technique. Three different stimulus-duration was used in this experiment : 30minutes, 1 hour and 2 hours. The summerized results were summerized as follow : 1. The number of Fos expression was significantly increased in the spinal cord dorsal horn depending upon the increase of stimulus-duration (P<0.05). Otherwise, there was no significant difference between 30 minutes EA treated group and anesthetic control. 2. High frequency EA biphasic stimulation significantly enhanced the Fos expression in the DR, middle and rostral portion of PAG LD, and caudal PAG LV after 1 hour and 2 hours treatment. The number of Fos immunoreactive neuron in the brainstem was increased accorcting to the length of stimulus-duration. Those results indicate that at least 1 hour EA treatment was necessary to increase the neuronal activities in the spinal cord and brainstem. Those basic data from this study can be applied to establish the effective treatment of EA for pain control in the clinical field.

개흉술후 동통억제를 위한 침의 효과

박동석,조규석,김수철,이재영,손성세 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1997 東西醫學硏究所 論文集 Vol.1997 No.-

개흉술을 시행받은 환자에 있어서 수술후 발생하는 동통은 해결하기 힘든 문제로 다양한 방법들이 시도되어 왔다. 저자들은 침의 효능에 주목하여 개흉술후 동통억제에 침치료가 얼마나 효과가 있는지를 관찰하였다. 1995년 3월부터 9월까지 흉부질환으로 액와 절개술을 이용한 개흉술을 시행받은 20례를 무작위로 2개의 군으로 분류하였다. 동통치료를 위해 통상적으로 사용하는 진통제를 투여한 군을 대조군(n=10)으로 하고 침치료를 시행한 군을 실험군(n=10)으로 하였다. 수술후 진통효과를 평가하기 위해 고려대학교 의과대학 흉부외과학교실에서 정한 수술후 통증에 대한 점수체계를 이용하였다. 환자가 느끼는 동통의 정도와 술측의 팔운동장애의 정도에서 두 군간의 유의한 차이는 없었다. 그러나 진통제의 투여회수는 침치료를 시행한 군에서 유의하게 감소하였다(p<0.05). 따라서 저자들은 개흉술을 시행받은 환자의 수술후 동통억제시 침술을 이용함으로써 진통제의 투여회수를 줄일 수 있으며 간기능 저하인 환자나 진통제 주사에 대해 부작용을 나타내는 환자에게 도움이 될 것으로 생각한다. The management of post-thoracotomy pain is one of the difficult clinical problems. A variety of pain management methods have been used with variable efficacy. We compared the effect of acupuncture with the effect of analgesics for the post-thoracotomy pain control. From March 1995 to September 1995, 20 patients who underwent elective thoracotomy were randomized into two groups. The patients were treated with analgesics in control group(n = 10) and acupuncture in the other group(n = l0). Postoperative analgesic effects were evaluated by the scoring system which was made by the Department of Thoracic and Cardio-vascular Surgery, Korea University Medical Center. No significant difference was observed between two groups concerning the subjective pain and limitation of motion of operated side. Although the number of analgesic requirement was reduced significantly in the acupuncture group(P<0.05). We conclude that acupuncture is an effective method to control post-thoracotomy pain and it is safer than the analgesics bacause of its lower side effects.

개흉술 후 동통억제를 위한 침의 효과에 관한 임상적 고찰

김수철,이윤호,박동석,이재영,조규석,손성세 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1996 東西醫學硏究所 論文集 Vol.1996 No.-

The effect of acupuncture on the post-thracotomy pain was studied on 20 patients who underwent thracotomy. We observed post-thracotomy pain control patients from April 1995 to September 1995 in Department of Thoracic and Cardiovascular Surgery, Kyung Hee Medical Center. The patients who received thracotomy were randomly allocated and divided into two groups. Control group was treated with analgesics. Experimental group was acupuncture treatment group, concist of needle insertion at four point; Chigu(TE6), Yangnungch'on(G34), Changmun(Liv13). Postoperative analgesic effects were evaluated by subjective pain, limited motion of operative side and analgesia requirement. The results were as followings. 1. The subjective pain of post surgery, the first two days were severe, but the pain decreased as the days passed, and there was no significant difference between the acupuncture and the control group. 2. Post surgery, limited motion of operative side was reduced as the days passed, there was no significant difference between the acupuncture and the control group. 3. The amount of analgesics taken into the acupuncture group was 0.4 times a day, the control group was taken 2.3 times a day, so there was a significant difference between the two groups. 4. The day of surgery and the 1st, 2nd, 3rd, 5th and 7th day, the average amount of analgesics taken into the acupuncture group was only 2.3 times within 6 day period but the control group was used 13.7 times within 6 day period therefore, the acupuncture group received much less analgesics than the other. According to the above results, post surgery of thracotomy, the use of acupunture will reduce the analgesics, also it will be effective on a patient with low liver function or side effect to analgesics.

원저 : 개흉술 후 동통억제를 위한 침의 효과에 관한 임상적 관찰 ( Original Article : The effect of Acupuncture on the Post - Thracotomy Pain )

손성세(Sung Sae Son),박동석(Dong Seok Park),이윤호(Yoon Ho Lee),이재영(Jae Young Lee),김수철(Soo Cheol Kim),조규석(Kyu Seok Cho) 경희대학교 경희의료원 1996 慶熙醫學 Vol.12 No.2

高頻度電鍼刺戟의 刺戟時間에 따른 中樞神經系 神經細胞의 活性變化에 미치는 影響

안병철,박동석,최용태,최도영,이윤호,남상수,이재동,손성세 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1998 東西醫學硏究所 論文集 Vol.1998 No.-

The present study was designed to investigate the effect of different stimulation-duration of high frequency electroacupuncture(EA) treatment on the neuronal activities in the spinal cord brainstem using Fos immunohistochemical technique. Three different stimulus-duration was used in this experiment: 30minutes, 1 hour and 2 hours. The summerized results were summerized as follow : 1. The number of Fos expression was significantly increased in the spinal cord dorsal horn depending upon the increase of stimulus-duration (P<0.05). Otherwise, there was no significant difference between 30 minutes EA treated group and anesthetic control. 2. High frequency EA biphasic stimulation significantly enhanced the Fos expression in the middle and rostral portion of PAG LD, and caudal PAG LV after 1 hour and 2 hours treatment, The number of Fos immunoreactive neuron in the brainstem was increased according to the length of stimulus-duration. Those results indicate that at least 1 hour EA treatment was necessary to increase the neuronal activities in the spinal cord and brainstem. Those basic data from this study can be applied to establish the effective treatment of EA for pain control in the clinical field.

高頻度電鍼刺戟의 波形에 따른 中樞神經系 神經細胞 및 腦幹의 Serotonin性 神經細胞의 活性變化에 미치는 影響

孫聖世,李潤浩,李裁東 慶熙大學校韓醫科大學韓醫學硏究所 1998 慶熙韓醫大論文集 Vol.21 No.1

The present study was designed to investigate the effect of different patterns of high frequency electroacupuncture(EA) treatment on the neuronal activities in the spinal cord and brainstem using Fos immunohistochemical technique. To analyze the effect of patterns of high frequency EA, the experimental animals were divided into three groups : high frequency biphasic rectangular wave treated group, high frequency positive monophasic rectangular wave treated group and high frequency negative monophasic rectangular wave treated group. Those different patterns of high frequency EA was applied to Zusanli point of experimental animals for two hours. The distribution and number of Fos positive neurons were evaluated in the spinal cord and brainstem. The summerized results were summerized as follow : 1. The patterns of high frequency EA increased number of Fos immunoreactive neurons in the laminae Ⅰ, Ⅱ and Ⅲ of the spinal cord dorsal horn compared to that of anesthetic control group(P<0.05). Among the different patterns of EA treatment, biphasic rectangular wave EA treatment showed dramatic increase in the number of Fos positive neurons of the spinal cord dorsal horn(P<0.05). 2. The increased neuronal activities was observed in the brainstem of high frequency biphasic and monophasic EA treated groups compared to that of control group(P<0.05). The biphasic and positive monophasic EA stimulation more effectively increased the Fos expression than negative monophasic EA stimulation. 3. The ratio of colocalization between serotonin containing neuron and Fos positive neuron in the brainstem was markedly increased in DR and middle portion of PAG LV as well as caudal portion of PAG LV after biphasic and positive monophasic EA stimulation for 2 hours. Those results indicate that high frequency biphasic EA stimulation is the most effective method to increase the neuronal activities in the spinal cord and brainstem for inducing analgesic effect of EA. In addition, the ratio of colocalization of serotoninergic neuron and Fos positive neurons is effectively increased by treatment of high frequency biphasic EA, suggesting that the analgesic effect of high frequency EA depends on the serotoninergic pathway of endogenous pain control system. Those basic data from this study can be applied to establish the effective treatment of EA for pain control in the clinical field.

화농성 척추염환자 치험 1례에 대한 임상적 고찰

고태현,손성세,최익선,엄재용,Ko, Tae-Hyun,Son, Sung-Se,Choi, Ik-Sun,Eom, Jae-Yong 대한침구의학회 2005 대한침구의학회지 Vol.22 No.4

Objectives : This report intended to estimate effect taken by using acupuncture, herbal medication on the patient with Pyogenic Spondylitis Methods : From 17 December, 2003 to 30 August, 2004. The patient received TDP, Infra-Red and Acupuncture therapy. Results : After being hospitalized for 8 months, the patient's Motor Grade, VAS, ODI, Nurick's grading system were improved each from III to IV+, from 5 to 4, from 21.25 to 17.5, from Gr. IV to Gr. II. Conclusion : We considered that oriental treatment has an useful effect on Pyogenic spondylitis patient's treatment and recovery.

산후 골반통에 추나 수기 요법의 효과에 대한 문헌 고찰

이미주,손성세,황덕상,이진무,장준복,이창훈 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.4

Objectives: The purpose of this review is to assess the effects of Chuna manipulation for postpartum pelvic pain and low back pain. Methods: To investigate the effects of Chuna manipulation for postpartum pelvic pain and low back pain, we searched the seven database (Korean Obstetrics and Gynecology, Oasis, National Digital Science Library, Pubmed, Cochrane Library, Embase, China National Knowledge Infrastructure) and manually checked related clinical trials up to May, 2019. Results: Seven studies were included in this review. Chuna and other manipulation (Osteopathy and Tuina) were effective in relieving postpartum pelvic pain and improving Oswestry Disability Index. Conclusion: This review suggests Chuna manipulation produces clinically relevant benefits for postpartum women with pelvic pain and low back pain. Further research may change estimates of effect, and larger, high-quality randomized controlled trials with robust comparison groups are recommended.

4번째 동측으로 발생한 벨마비의 치험 1례

김남옥,채상진,손성세,Kim Nam-Ok,Chae Sang-Jin,Son Sung-Se 대한한방안이비인후피부과학회 2001 한방안이비인후피부과학회지 Vol.14 No.2

Recurrent Bell's palsy is a very rare case and have been reported that shows the incidence to be approximately 10 per cent in the Bell's palsy patents. It is generally accepted that facial paralysis caused by compression of the facial nerve by tumor develops slowly and has an unremitting course, however, reported cases have described the rare association of recurrent facial paralysis and intracranial tumor, and the same recovery rate. Usual symptoms of Bell's palsy include subacute facial palsy, hyperacusis on the affected side, postauricular pain on the affected side, altered sensation of taste, and partial trigeminal distribution hypesthesias. Complete resolution of symptoms is usually seen in 2-3months in $75-85\%$ of cases, with $25-35\%$ showing varying degrees of residual effects. We report a case of 4th ipsilateral recurrent Bell's palsy in a 14-year-old women, which was occurred in every winters. We treated her with acupuncture, moxibustion, herbal medication, carbon and silver spike point, and used House-Brackmnn grading system(HBGS) and the Fisch Detailed Evaluation of Facial Symmetry(DEFS) to assess the degree of paralysis in each part of face.

산후 한약 복용이 간기능에 미치는 영향 : 후향적 차트 리뷰

이미주,이혜정,손성세 대한한방부인과학회 2023 大韓韓方婦人科學會誌 Vol.36 No.4

Objectives: The purpose of this study is to investigate safety of postpartum herbal medicine by assessing the effect of taking herbal medicine of postpartum period on liver function. Methods: A retrospective chart review was conducted on 167 mothers who underwent liver function tests (LFT) within 3 months before and after childbirth among mothers who gave birth at ○○ Hospital between January 1, 2016 and May 31, 2018. Mothers with abnormally elevated LFT during pregnancy were excluded. Among 167 women, 6 women are herbal-medicine-group took herbal medicine for 5-6 weeks during postpartum period, and 161 patients are general -group who did not take herbal medicine. LFT Variation of Subjects before and after childbirth were compared between the two groups. And subjects who had elevated liver levels above the normal range after delivery were classified separately, the characteristics and causes of changes in liver levels were analyzed, and the presence or absence of drug-induced liver damage was confirmed. Results: Among a total of 167 subjects, there were 5 women in the herbal-medicine -group and 150 women in the general-group who had changes in liver values within the normal range after childbirth. Aspartate transaminase (AST) change before and after childbirth in the herbal-medicine-group was 3.40±1.82, and AST change in the general-group was 2.92±8.59, showing no significant difference between the two groups (p=0.901). Increase of Alanine transaminase (ALT) before and after childbirth in the herbal-medicine-group was 5.60±3.65, and ALT change in the general-group was 8.01± 11.81, showing no significant difference between the two groups (p=0.651). There were 12 subjects who had elevated AST, ALT above the normal range after delivery, including 1 in the herbal-medicine-group and 11 in the normal mothers group. Valuation of 1 Subject of the herbal-medicine-group before and after delivery was 17 IU/L of AST and 52 IU/L of ALT. Because results of AST, ALT is under the standard to diagnose to liver damage, she was observed without any treatment. However the cause of AST, ALT elevation was not found in the chart, she was receiving treatment for diabetes and hyperlipidemia. The general-group had an average increase of AST 35.64±22.67 IU/L and ALT 53.00± 26.80 IU/L. As a result of analyzing the cause, there were direct causes such as autoimmune hepatitis, chronic hepatitis B, and acute pyelonephritis. Abnormal elevations in liver levels were also found in mothers with hypothyroidism, diabetes, and fever of unknown cause, although they were not direct causes. Conclusions: To investigate the safety of taking herbal medicines, we assess the variation in AST and ALT within 3 months before and after delivery in the herbal-medicine -group and general-group. There was no significant difference between two groups.