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경계성 절제가능형 췌장암의 치료와 국소 진행형 췌장암의 국소 치료
손병관 ( Byoung Kwan Son ) 대한췌장담도학회 2015 대한췌담도학회지 Vol.20 No.1
With the advances in the imaging techniques, it is now possible to more accurately diagnose and stage pancreatic cancer. However, there is no uniform definition of “borderline resectable pancreatic cancer (BRPC)” and consensus on this terminology has not been reached yet. Although there has been much progress in the therapeutic strategies for pancreatic cancer, the optimal treatment scheme for BRPC is still under debate. In order to overcome these problems, prospective studies using multidisciplinary approaches are warranted. This article is intended to review the currently available definitions and management of BRPC. Promising novel ablative methods that are used as local treatments for locally advanced pancreatic cancer are also introduced. In the near future, these ablative methods might prove to be invaluable for those with BRPC.
내시경 역행성 담췌관조영술에서 시술자에 대한 방사선 방호의 부족
손병관 ( Byoung Kwan Son ),이규택 ( Kyu Taek Lee ),김재선 ( Jae Seon Kim ),이승옥 ( Seung Ok Lee ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.2
Background/Aims: ERCP using fluoroscopy should be practiced with an adequate radiation protection. However, the awareness of gastrointestinal endoscopists to radiation protection was considered insufficient. In Korea, a country with a rapid increase the number of ERCP procedures, there is no data about radiation protection practices for gastrointestinal endoscopists. The purpose of this study was to investigate current clinical practices and the awareness on radiation protection in ERCP performing physicians in Korea. Methods: An anonymous questionnaire regarding radiation protection practices was mailed to 100 members of Korean Pancreatobiliary Association who was porforming ERCP. The questionnaire included ERCP volume of each endoscopist, use of protection devices such as apron, thyroid shield, lead glasses and any mobile shield for scattered radiation, and whether they monitored their own radiation exposure dosage. Results: All respondents wore lead aprons during ERCP. While 52.5% of endoscopists answered that they always wear thyroid guards, 26.9% rarely or never wore it. Only 14% wore lead glasses during the procedure and 69% never wore it. The preparation rates of mobile shields or lead curtains were only 14% and 24%, respectively. Only 10% of endoscopists attached an X-ray badge and 66.7% never used it. Moreover, 75% of endoscopists responded that they did not monitor their own exposure dose to radiation during ERCP. Conclusions: The lack of radiation protection of ERCP endoscopists in Korea was seemed serious. Awareness of radiation hazard should be more concerned and educated in parallel with the preparation of radiation protection equipments. (Korean J Gastroenterol 2011;58:93-99)
손병관 ( Byoung Kwan Son ),손주현 ( Joo Hyun Sohn ),장명희 ( Myung Hee Chang ),박윤경 ( Yoon Kyung Park ),김태엽 ( Tae Yeob Kim ),전용철 ( Yong Cheol Jeon ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.5
Duodenal varix is a rare cause of hemorrhage in patients with portal hypertension, however their rupture is serious and often life threatening. Treatments for duodenal variceal bleeding include endoscopic procedures, surgery, or interventional radiologic procedures. We report a case of duodenal varices rupture in a 45-year-old man with alcoholic liver cirrhosis who presented with melena and dizziness. Emergent upper endoscopy revealed large nodular varices with a ruptured erosion on the top in the distal second portion of duodenum. Two consecutive injections with 1.0 mL of n-butyl-2-cyanoacrylate (Histoacryl; Braun-Melsungen, Germany) mixed with 1.0 mL of lipiodol (Laboratoire-Guerbet, France) were performed intravariceally and achieved successful hemostasis. This suggests that endoscopic injection sclerotherapy with histoacryl may be an effective therapeutic option for the control of ruptured duodenal variceal bleeding. (Korean J Gastroenterol 2007;49:336-340)
대장 선종의 위험 인자로 복부 비만 및 인슐린 저항성에 대한 연구
이항락 ( Hang Lak Lee ),손병관 ( Byoung Kwan Son ),이오영 ( Oh Young Lee ),전용철 ( Yong Chul Jeon ),한동수 ( Dong Soo Han ),손주현 ( Ju Hyun Sohn ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( Joon Soo Hahm ),이민 대한소화기학회 2007 대한소화기학회지 Vol.49 No.3
목적: 대장암은 유전 소인, 흡연, 음주, 식습관 등의 환경인자가 작용하여 발생하며 또한 비만, 고지혈증, 고혈당, 고인슐린 혈증 및 인슐린 저항성이 대장암의 발암과정과 연관이 있다. 다양한 비만 지표를 이용해서 대장 선종과 비만 및 인슐린 저항성과의 연관성을 알아보고자 하였다. 대상 및 방법: 2004년 1월부터 2004년 10월까지 한양대학병원에서 검진 목적으로 대장내시경검사와 기타 검사를 시행 받은 환자를 대상으로 전향적으로 환자 대조군 연구를 시행했다. 크기가 0.5 cm 이상이며 조직학적으로 대장 선종이 증명된 50명의 환자를 대상으로 했으며, 대조군은 동일 기간 중 대장내시경검사를 시행 받았으나 특이 병변이 없었던 자로 정했다. 결과: 인슐린, 공복혈당, 총 콜레스테롤, triglyceride, LDL, HDL 수치, 수축기 및 이완기 혈압은 환자군에서 모두 증가되었으나 환자군과 대조군 사이에 유의한 차이는 없었다. HOMA-IR은 환자군에서 인슐린 저항성 수치가 높았으나 통계적인 유의성은 없었다. 그러나 체질량지수, 복부 비만, 체지방, 비만도는 환자군이 대조군 보다 유의하게 높았다. 다변량 분석에서 복부 비만이 가장 의미 있는 위험 인자였으며 체질량지수가 증가함에 따라 대장 선종의 위험도도 증가했다. 체지방, 비만도 역시 중요한 위험 인자였다. 결론: 비만과 대장 선종의 연관성에서 복부 비만이 가장 중요한 위험 인자였으며 복강 내 지방조직이 중요한 역할을 할 것으로 기대한다. 향후 대규모의 환자 대조군 및 코호트 연구가 필요하며 복강 내 지방의 역할에 대한 분자생물학적인 연구가 필요하다. Background/Aims: Abdominal obesity and hyperinsulinemia or insulin resistance are of interest in connection with colon carcinogenesis. We conducted a prospective case controlled study for the evaluation of relationship between abdominal obesity, insulin resistance, and colorectal adenoma. Methods: Fifty patients with colorectal adenoma and fifty healthy subjects were included in this study. Total colonoscopic examinations were performed in all the subjects. Fasting blood sugar (FBS), insulin, homeostasis model assessment (HOMA-IR), triglyceride (TG), cholesterol (CROL), BMI (body mass index), WHR (waist hip ratio), percent body fat (PBF) and obesity degree (OD) were measured. HOMA-IR was considered to represent insulin resistance. Diabetic patients were excluded from this study. Results: There were no differences in sex, serum insulin, FBS, HOMA-IR, TG, CROL between adenoma and control group. Subjects with high BMI, WHR, percent body fat, and obesity were more likely to have colonic adenoma. Multiple logistic regression analysis after adjusting confounding factors, had revealed that WHR was the most important independent risk factor for colon adenoma. Conclusions: Abdominal obesity was most closely related to colonic adenoma. However, insulin resistance was not related to colonic adenoma. A larger case controlled study is needed. (Korean J Gastroenterol 2007;49:147-151)
75세 여자 환자에서 재발성 간성뇌증으로 발현한 유전성 출혈성 혈관 확장증
하정훈 ( Jung Hoon Ha ),손병관 ( Byoung Kwan Son ),안상봉 ( Sang Bong Ahn ),조영관 ( Young Kwan Jo ),김성환 ( Seong Hwan Kim ),조윤주 ( Yun Ju Jo ),박영숙 ( Young Sook Park ),정윤영 ( Yoon Young Jung ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.1
Osler-Weber-Rendu disease is a rare autosomal dominant disorder of fibrovascular tissues, characterized by a classic triad of mucocutaneous telangiectasias, recurrent hemorrhages, and a familial occurrence. Portosystemic encephalopathy in a patient with Osler-Weber-Rendu disease is rare, but we experienced a case presenting with recurrent portosystemic encephalopathy in Osler-Weber-Rendu disease. We report on a case of a 75-year-old female presenting with an altered mentality. Initial studies including brain imaging study did not reveal any specific cause for her mental status. She was diagnosed with the rare disease after a series of tests and received conservative treatment. Her neurological status recovered fully without complication after conservative treatment and she was discharged after 18 hospital days. This case demonstrated an extremely rare case of Osler-Weber-Rendu disease presenting as portosystemic encephalopathy treated successfully with conservative treatment. For patients who have shown hepatic encephalopathy without a definite cause, we recommend evaluation for the possibility of Osler-Weber-Rendu disease. Conservative treatment based on treatment of advanced liver cirrhosis could be an alternative solution.
오일환 ( Il Hwan Oh ),손병관 ( Byoung Kwan Son ) 대한췌담도학회 2018 대한췌담도학회지 Vol.23 No.4
십이지장경은 선단부에 겸자올림 장치와 겸자올림 와이어 채널 같은 복잡한 구조를 가지고 있기 때문에 세척과 소독에 어려움이 많다. 이러한 이유로 십이지장경에 의한 교차 전염의 주된 원인은 불충분한 내시경 재처리로 인식되어 왔다. 그러나 최근 십이지장경을 통한 카바페넴 내성 장내세균 및 다른 다제내성균 교차전염은 적절한 십이지장경 재처리를 준수하였는데도 불구하고 발병하였다. 따라서 현재는 십이지장경에 적합한 재처리 지침을 재정립하여야 하고 십이지장경 재처리를 좀 더 용이하게 하기 위하여 선단부의 디자인을 개선해야 할 시점일 것이다. 본고는 십이지장경 연관 감염에 대한 현 상황과 외국의 대처방안 및 한계에 대해서 검토하고 십이지장경 연관 감염을 방지하기 위한 향후 대처방안에 대해서 논하고자 한다. A duodenoscope is complex instrument with an elevator and an elevator wire channel which are difficult to access and not readily amenable to cleaning and disinfection. Lapses in endoscope reprocessing have been regarded as a major cause of duodenoscope-associated transmission of infection. However, recent outbreaks of carbapenem-resistant Enterobacteriaceae or other multidrug-resistant organisms have emerged in spite of proper adherence to the manufacturer’s reprocessing instructions. It is the time to reestablish reprocessing protocol appropriate for duodenoscope and revise a new design of duodenoscope that makes reprocessing easier in order to prevent cross-transmission of infection by duodenoscope. This manuscript reviews current state of duodenoscope-associated infections, recent measures from the United States government agencies and its limitations, and future strategies to prevent duodenoscope-associated infections. Korean J Pancreas Biliary Tract 2018;23(4):145-149
김병욱 ( Byung-wook Kim ),손병관 ( Byoung Kwan Son ),김원희 ( Won Hee Kim ),명대성 ( Dae-sung Myung ),조영석 ( Young-seok Cho ),장병익 ( Byung Ik Jang ) 대한내과학회 2017 대한내과학회지 Vol.92 No.3
Korean Society of Gastrointestinal Endoscopy (KSGE) issued its guidelines for endoscope reprocessing for the first time in 1995, and the version of the guidelines has been updated in August 2009, August 2012 and March 2015, respectively. Guidelines for endoscope reprocessing should be revised continuously because new disinfectants and devices are introduced. The current official version of the KSGE guidelines for endoscope reprocessing is explained herein to assist the reader in understanding of KSGE requirements for cleaning and disinfection of endoscopes. (Korean J Med 2017;92:239-244)