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Bioactive Activities of Natural Products against Herpesvirus Infection
손명기,이민정,성기호,이태호,Yu Su Shin,Hyosun Cho,Paul M. Lieberman,강효정 한국미생물학회 2013 The journal of microbiology Vol.51 No.5
More than 90% of adults have been infected with at least one human herpesvirus, which establish long-term latent infection for the life of the host. While anti-viral drugs exist that limit herpesvirus replication, many of these are ineffective against latent infection. Moreover, drug-resistant strains of herpesvirus emerge following chemotherapeutic treatment. For example, resistance to acyclovir and related nucleoside analogues can occur when mutations arise in either HSV thymidine kinase or DNA polymerases. Thus, there exists an unmet medical need to develop new anti-herpesvirus agents with different mechanisms of action. In this Review, we discuss the promise of anti-herpetic substances derived from natural products including extracts and pure compounds from potential herbal medicines. One example is Glycyrrhizic acid isolated from licorice that shows promising antiviral activity towards human gammaherpesviruses. Secondly, we discuss anti-herpetic mechanisms utilized by several natural products in molecular level. While nucleoside analogues inhibit replicating herpesviruses in lytic replication, some natural products can disrupt the herpesvirus latent infection in the host cell. In addition, natural products can stimulate immune responses against herpesviral infection. These findings suggest that natural products could be one of the best choices for development of new treatments for latent herpesvirus infection, and may provide synergistic anti-viral activity when supplemented with nucleoside analogues. Therefore, it is important to identify which natural products are more efficacious anti-herpetic agents, and to understand the molecular mechanism in detail for further advance in the anti-viral therapies.
손명기 대한건축학회 1996 建築 Vol.40 No.6
일부 대규모 설계사무소를 제외한 대부분의 설계사무소의 컴퓨터 이용은 반복작업에 따른 인력과 시간절감을 위한 도면작성용 CAD정도이며, 설계에서 생산까지의 일관된 컴퓨터 이용시스템에 해당되는 CAD/CAM의 핵심단계이자 '통합적 정보화' 단계라 할 수 있는 '엔지니어링 데이터 베이스(Engineering Data Base:EDB)' 구축은 거의 이루어지지 않고 있는 실정이다.
손명기(Son Myong Gi) 구결학회 2005 구결연구 Vol.15 No.-
이 글은 점토석독구결 자료인『瑜伽師地論』(Yogac?rab??mi) 권8 중 13장 8행부터 14장 8행까지의 해독 방안을 모색한 것이다. This paper surveys the contents of ‘Yogac?rab??mi(瑜伽師地論) vol. 8, 13:08-14:08’ and presents a tentative decoding and interpretation of cipher kugyols inscribed in a part of that volume.