윤리적 성향에 따른 집단 간 환경 리터러시와 친환경 행동의 차이

소병훈,유역준,독몽기,왕일범 한국방송학회 2023 한국방송학회 학술대회 논문집 Vol.2023 No.11

Exercise-induced myokines in health and metabolic diseases

소병훈,김희재,김진수,송욱 한국한의학연구원 2014 Integrative Medicine Research Vol.3 No.4

Skeletal muscle has been emerging as a research field since the past 2 decades. Contraction of a muscle, which acts as a secretory organ, stimulates production, secretion, and expression of cytokines or other muscle fiber-derived peptides, i.e., myokines. Exercise-induced myokines influence crosstalk between different organs in an autocrine, endocrine, or paracrine fashion. Myokines are recently recognized as potential candidates for treating metabolic diseases through their ability to stimulate AMP-activated protein kinase signaling, increase glucose uptake, and improve lipolysis. Myokines may have positive effects on metabolic disorders, type 2 diabetes, or obesity. Numerous studies on myokines suggested that myokines offer a potential treatment option for preventing metabolic diseases. This review summarizes the current understanding of the positive effects of exercise-induced myokines, such as interleukin-15, brain-derived neurotrophic factor, leukemia inhibitory factor, irisin, fibroblast growth factor 21, and secreted protein acidic and rich in cysteine, on metabolic diseases.

장내 미생물, 당신의 운동 능력을 변화시킵니다!

소병훈 한국스포츠정책과학원 2022 스포츠과학 Vol.161 No.-

시스템좌굴 해석법을 이용한 라멘형가교 주요부재의 좌굴설계에 관한 사례 연구

경용수,소병훈,방진환,김문영,Kyung, Yong Soo,So, Byoung Hoon,Bang, Jin Hwan,Kim, Moon Young 한국강구조학회 2007 韓國鋼構造學會 論文集 Vol.19 No.1

일반적으로 가교량은 주형와 강재교각이 강결 연결된 강재 라멘구조를 형성하고 있다. 강재 라멘구조의 경우, 작용하는 하중에 의해 축력 및 휨을 받는 부재/축력 및 휨을 동시에 받는 부재가 발생한다. 본 연구에서는 이러한 부재에 대해서 시스템 좌굴해석을 통하여 가교량 주요부재의 유효길이를 산정하고 이를 이용하여 안정성 해석을 수행한다. 이를 위하여 실제 설계/시공될 수 있는 가교의 6가지 유형을 선택하고, 고정하중, 온도하중 그리고, 활하중조합에 대한 3차원 좌굴설계를 실시한다. 결과적으로 6가지 가교에 대한 사례연구를 통하여 주형 및 교각부의 유효길이 산정법, 3차원 좌굴모드에 대한 고찰, 그리고 2차해석의 효용을 조사한다. Generally, main girders and steel piers of temporary bridges form the steel rahmen structure. In this study, the rational stability design procedure for main members of temporary bridges was presented using a 3D system buckling analysis and second-order elastic analysis. Six types of temporary bridges, which can be designed and fabricated in reality, were chosen and the buckling design for them was performed in consideration ofload combinations of dead and live loads, thermal load, and wind load. Effective buckling length of steel piers, transition of 3D buckling modes, and effects of second-order analysis were investigated through a case study involving six temporary bridges.

운동으로 유도되는 Irisin의 역할

김희재,소병훈,손준석,송한솔,송욱 서울대학교 스포츠과학연구소 2016 스포츠과학리뷰 Vol.9 No.1

최근연구에따르면골격근은여러가지사이토카인을분비하는하나의내분비기관으로여 겨지고 있다. 수축하는 근육에서 분비되는 사이토카인은 마이오카인으로 명명하고 있으며, 운동으로 인해 유도되는 마이오카인은 여러 가지 생리학적, 병리학적 기전에 관여하고 있 다고보고되었다. 마이오카인의 정의는 수축하는골격근에서 생성되고, 발현되고, 분비되는 사이토카인 혹은 작은 펩파티드를 의미하고 이는 autocine, paracrine, 혹은 endocrine 형태 로 그 역할을 한다. 최근 알려진 대표적인 마이오카인에는 irisin, interleukin 15 (IL-15), leukemia inhibitory factor (LIF), brain derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF-21), secreted protein acidic and rich in cystein (SPARC) 등이 있다. 이중에서 irisin이라는 마이오카인은 백색지방조직의 갈색지방화 시키는 중요한 매개 물질 로여겨지고있다. 본리뷰논문에서는노화및대사증후군에서irisin의역할에대해서지금 까지나온연구들을정리하고, 앞으로irisin 연구의방향에대해서간략하게논의하고자한 다. Skeletal muscle has recently been recognized as an endocrine organ that produces and releases various cytokines termed myokine that are involved in the regulation of several physiological and metabolic pathways. Myokines are identified as cytokines and other peptides that are produced, expressed and released by muscle fibers and exert autocrine, paracrine or endocrine effects. In response to muscle contraction following exercise, muscle fiber express myokines such as irisin, interleukin 15 (IL-15), leukemia inhibitory factor (LIF), brain derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF-21), and secreted protein acidic and rich in cystein (SPARC), which subsequently exerts their effect locally within the muscle or their target organ. Among these myokines, irisin was identified as a potential mediator of exercise-induced incresaes in thermogenic gene in the adipose tissue. In the present review, we focused on the role of irisin in aging and metabolic diseases including obesity and diabetes.

Resistance training inhibited the elevation of skeletal muscle derived-BDNF expression concomitant with improvement of muscle strength in zucker diabetic rat

김희재,소병훈,손준석,송한솔,오승렬,성재경,이호영,송욱 한국운동영양학회 2015 Physical Activity and Nutrition (Phys Act Nutr) Vol.19 No.4

Purpose: In the present study, we investigated the effects of 8 weeks of progressive resistance training on the expression of skeletal muscle derived BDNF as well as glucose intolerance and muscle quality in Zucker diabetic rats. Methods: Six week-old male Zucker diabetic fatty (ZDF) and Zucker lean control (ZLC) rats were randomly divided into 3 groups: sedentary ZLC (ZLC-Con), sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). Progressive resistance training using a ladder and tail weights was performed for 8 weeks (3 days/week). Results: After 8 weeks of resistance training, substantial reduction in body weight was observed in ZDF-Ex compared to ZDF-Con. Though the skeletal muscle volume did not change, grip strength and muscle quality significantly increased in ZDF-Ex compared to ZDF-Con. In the soleus, the expression of BDNF was increased in ZDF-Con, but was significantly decreased (p<0.05) in ZDF-Ex, showing a training effect. Moreover, we found that there was a negative correlation (r= -0.657; p=0.004) between grip strength and BDNF expression whereas there was a positive correlation (r=0.612; p=0.008) between plasma glucose level and BDNF expression in skeletal muscle. Conclusion: Based upon our results, we demonstrated that resistance training inhibited the elevation of skeletal muscle derived-BDNF expression concomitant with the improvement of muscle strength in zucker diabetic rats. In addition, muscle-derived BDNF might be a potential mediator for the preventive effect of resistance training on the progress of type 2 diabetes. Keywords: type 2 diabetes, exercise training, zucker diabetic fatty, muscle quality

근감소증 예방을 위한 저항성 운동의 실제적 적용

김희재,윤동현,소병훈,손준석,송한솔,김대영,황수승,강민지,이동원,한가영,송욱 대한노인병학회 2015 Annals of geriatric medicine and research Vol.19 No.4

Sarcopenia is a major component of age-related frailty and also a strong predictor of disability, morbidity, and mortality in the aging population. Resistance exercise could be the most effective intervention that improves muscle mass, muscle strength and physical performance, thus preventing sarcopenia in older adults. The benefits of these exercise programs correlate with the intensity and the frequency of the exercise regimes used in the trials. Clinical trials vary in terms of population, setting, and exercise regimes; hence, more standardized clinical trials are required. In this review, we focus on the effects of resistance exercise on muscle mass, strength, cognitive and physical function, and the principle and applications of resistance exercise considering recent trends that include high-intensity interval training, high speed power training, eccentric exercise, and whole-body vibration exercise.

단기간 트레드밀 운동을 통한 in vivo 미토파지 실험모델 검증

김동현 ( Donghyun Kim ),소병훈 ( Byunghun So ),박진한 ( Jinhan Park ),강청훈 ( Chounghun Kang ) 한국체육학회 2021 한국체육학회지 Vol.60 No.4

미토콘드리아는 에너지공급 및 다양한 신호전달을 통해 세포의 항상성에 관여한다. 미토콘드리아의 손상은 만성질환과 밀접하게 관련되어 있으며, 질병 치료 및 예방목적으로 활발하게 연구되고 있다. 미토파지(mitophagy)는 손상된 미토콘드리아를 선택적으로 제거하여 세포기능의 유지 및 개선에 중요한 역할을 담당하는 세포 작용이다. 규칙적인 운동은 손상된 미토콘드리아를 제거하여 미토콘드리아 질적 조절을 통해 생리적 대사 및 기능을 제어하는 것으로 알려져 있다. 지금까지 미토파지 평가에 대한 연구방법은 많이 발전되어 왔지만, 미토파지 관련 현상의 in vivo 검증은 부족하다. 따라서 본 연구는 1주간의 마우스 트레드밀 운동이 골격근의 선택적 미토콘드리아 제거 신호에 미치는 영향을 mt-Kiema 마우스를 통해 분석하였다. 그 결과, 운동(EX)군이 대조(CON)군에 비해 더 높은 미토파지(red 형광) 수준을 나타냈으며, 이는 미토파지-관련 단백질 발현 결과와 유사성을 보였다. 본 연구는 in vivo 미토파지 평가 모델을 통해 미토콘드리아 질적조절에 대한 운동중재 효과를 보다 정확하게 검증할 수 있는 방법으로, 향후 본 연구모델의 활용가치가 높을 것으로 사료된다. Mitochondria are intracellular organelles, involve in regulating cellular homeostasis through various signaling pathways. Damaged mitochondria are closely related to chronic diseases, and have been actively studied for the patho-physiologic conditions. Mitophagy is a cellular mechanism of action that plays an important role in maintaining and improving cellular functions by selectively removing damaged mitochondria and exercise regimen is known to regulate mitochondrial quality control including the process of mitophagy. In this study, the effect of treadmill exercise for 1 week on the in vivo mitophagy of skeletal muscle was analyzed using mt-keima transgenic mice. As a result, the higher red fluorescence (pH 4.0; excitation: 561nm, emission range: 570-695nm) ratio was observed on confocal microscopy in the exercise (EX) group vs. the control (CON) group. These results were also consistent with the data that observed protein levels which are known to be induced during mitophagy. Therefore, the effect of exercise intervention on mitochondrial quality control can be more accurately verified through validation using the in vivo mitophagy evaluation model, mt-Kiema mice.

시스템좌굴해석법을 이용한 가교 주요부재의 유효좌굴길이 결정

경용수(Kyung Yong Soo),소병훈(So Byung Hun),방진환(Bang Jin Hwan),김문영(Kim Moon Yong) 대한토목학회 2005 대한토목학회 학술대회 Vol.2005 No.10

Effect of Treadmill Exercise on Interleukin-15Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats

김희재,박재영,오승렬,김용안,소병훈,성재경,송욱 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.5

Background: Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models. Methods: Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles. Results: After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04). Conclusion: The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.