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4 - 치환 - 1 , 2 - Benzothiazine - 3 - carboxamide - 1 , 1 - dioxide 의 합성 및 항염작용
서정진,홍유화,김병채 한국약제학회 1987 Journal of Pharmaceutical Investigation Vol.17 No.2
4-Pivaloyloxy, 4-benzenesulfonyloxy and 4-ρ-toluenesulfonyloxy compounds of piroxicam (2a, 2b and 2c) and isoxicam(4a, 4b and 4c) were synthesized in fairly good yield. Antiinflammatory and ulcerogenic effects of the 6 compounds were determined. Antiinflammatory effect of 2a was comparable to that of piroxicam and ulcerogenic effect of 2a was less than that of piroxicam.
서정진 대한영상의학회 1990 대한영상의학회지 Vol.26 No.2
Most benign esophageal strictures can be successfully dilated with conventional bougienage technique. But occasionally strictures are so tight, lengthy, or sometimes irregular that this technique fail and surgical intervention is required. Since 1974 Gruentzig balloon catheter has succeeded when used for strictures in the cardiac and peripheral vasculatures, the biliary and urinary tracts, the colon of neonates after inflammatory disease and also in the esophagus. fluoroscopically guided balloon catheters were used to dilate 30 esophageal strictures in30 patients over 3 years at department of Diagnostic Radiology Chonnam University, College of Medicine. The distribution of age was from 7 years to 71 days and the ratio of male to female was 15 : 15. The causes of benign stricture (23 cases) were post-operative strictures (13), chemical (4), achalasia 93), chronic inflammation (2), esophageal rupture 91) and those 0f malignant stricture 97 cases) were post-radiation stricture of primary esophageal cancer 96) & metastatic esophageal cancer 91). The success rate of procedure was 93% (28/30). The causes of failure were the failure of passage of stricture due to markedly dilated proximal segment of esophagus 91 case) and too long segment of stricture (1 case). Complication of procedure was the diverticula-formation of esophagus in 3 cases, but has no clinical significance in follow-up esophagography. In conclusion, fluoroscoically guided ballon dilation of esophageal stricture appears to be safe, effective treatment and may be have theoritical advantages over conventional bougienage and also should be considered before other methods of treatment are used.
서정진,이봉용,Suh, Jung-Jin,Lee, Bong-Yong 대한약학회 1989 약학회지 Vol.33 No.1
As potential xanthine bronchodilators related to Doxofylline (1b), 2-(7-theophyllineethyl)-1,3-dioxolane (3), 7-(3,3-dimethoxypropyl) theophylline(5), 2-methyl, 2-(7-theophyllinemethyl)-1,3- dioxolane (8a), 2-phenyl, 2-(7-theophyllinemethyl)-1,3-dioxolane (8b) and 2-(7-theophyllinemethyl)-1,3-benzodioxolane(14) were synthesized from theophylline (1a).
저압배전선로 전압안정화를 위한 상태관측과 반복제어를 적용한 무효전력 보상기
서정진,김영록,차한주 대한전기학회 2020 전기학회논문지 Vol.69 No.11
In this paper, a new reactive power control algorithm using a stat observer and repetitive control for voltage adjustment to the low-voltage distribution line is proposed and verified by simulation and experiment. A reactive power compensator has a single -phase full bridge inverter structure and consists of DC voltage controller to maintain a constant DC voltage, and current controller for reactive power generation. A DC ripple compensation method use an output from the state observer and the output is used as the DC voltage controller feedback to regulate the DC voltage constant. In order to inject a stable reactive power, the fundamental component of current is controlled by a PI controller, and a repetitive controller is connected in parallel with the PI controller to compensate for lower-order harmonics. The repetitive controller, as implemented in the synchronous coordinate system, serves to eliminate low-order odd harmonic components. The proposed control technique is experimented with a ±5kVar single phase inverter system and verified the performance of the proposed algorithm by confirming that THD is reduced to 2% from 9%.
서정진,홍유화 대한약학회 1987 약학회지 Vol.31 No.4
2-Cyclohexylimino-3-cyclohexyl-5-methyl-4-oxo-2H, 5H-1, 3-oxazino [5,6-C]-1, 2-benzothiazine-6,6-dioxide 2 was hydrolized in d-HCl/$CH_3$CN to give 5-methyl-3-cyclohexyl-2H, 5H-1, 3-oxazino [5, 6-C]-1, 2-benzothiazine-2, 4(3H)-dione 6, 6-dioxide 3 in 82% yield. The alkaline hydrolysis of 3 afforded to 4-hydroxy-2-methyl-N-(cyclohexyl)-2H-1, 2-benzothiazine-3-carboxamide-1, 1-dioxide 4 in 88% yield. On the other hand 3 was synthesized from 4 and ethylchloroformate on the reversed procedure.