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- 저자 : 변석호 (검색결과 42 건)
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연령연관황반변성에서 망막혈관종성증식과 동반된 망막색소상피 박리의 임상양상과 일차적인 광역학치료의 결과
변석호,홍진표,이효,오상준,김성수,고형준,이성철,권오웅 대한안과학회 2006 대한안과학회지 Vol.47 No.9
Purpose: To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin. Methods: Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment. Results: The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium. Conclusions: Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.
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선천성 수정체 결손증 환자에 적용된 인공수정체 광학부 포획 1예
변석호,김완수 대한안과학회 2006 대한안과학회지 Vol.47 No.11
Purpose: To report the effect of the optic capture in the treatment of congenital lens coloboma. Methods: A 5-year old boy was transferred to Maryknoll Hospital with congenital lens coloboma in his right eye. Lens coloboma at superotemporal area and capsular cataract around the coloboma was observed in the slit lamp examination. Posterior continuous curvillinear capsulorrhexis was performed after irrigation and aspiration of the lens. Optic was captured behind the posterior capsule while its haptics were placed in the sulcus. Results: Best corrected visual acuity improved from preoperative 20/63 to 20/20 postoperatively. Intraocular lens decentration and rotation and other sight threatening complications were not found during the follow up period. Conclusions: Optic capture is thought to be a safe and effective means to prevent IOL decentration and posterior capsular opacity in the treatment of congenital lens colobomas.
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변석호,김완수,Suk Ho Byeun,M,D,Wan Soo Kim,M,D,Ph,D 대한안과학회 2006 대한안과학회지 Vol.47 No.10
Purpose: To evaluate the stability of three different hydrophilic acrylic intraocular lenses (IOLs), which have different shapes. IOLs included in this study are three-piece acrylic IOL with PMMA (Polymethylmethacrylate) haptics (Hydroview? H60M, Bausch &Lomb, U.S.A), one-piece acrylic IOL with broad optic-haptic junction (Centerflex?570H, RAYNER, UK), and one-piece acrylic IOL with narrow optic-haptic junction (Aquasens, Ophthalmic Innovations International, U.S.A). Methods: We evaluated 69 patients (100 eyes) who had undergone cataract surgeries and who had hydrophilic acrylic IOLs implanted from September, 2003 to March, 2004. Forty eyes implanted with three-piece acrylic IOL with PMMA haptics, 40 eyes implanted with one-piece acrylic IOL with broad optic-haptic junction, and 20 eyes implanted with one-piece acrylic IOL with narrow optic-haptic junction were included. Slit lamp examination, best corrected visual acuity (BCVA), anterior chamber depth (ACD), refraction, and IOL decentration were evaluated at one week and at one, three, and six months postoperatively. Results: There was no statistically significant difference in BCVA, ACD, mean SE or decentration between patients implanted with three different types of hydrophilic acrylic IOL during the 6 month follow-up period (P>0.05). However, Postoperative myopic shift was discovered in 4 eyes (4/20) with Aquasens. Conclusions: There were no statistically significant difference in the Stabilities of the 3-different hydrophilic acrylic IOLs. However, patients who were implanted Aquasens shold be observed carefully because Aquasense has the posibilitiy to have myopic shift more than 1 Dioptor.
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한국인의 혈관내피성장인자 3’ 비번역 부위의 유전자 다형성과 당뇨망막증과의 상관성
변석호,오현섭,안보영,홍선표,김진국,권오웅 대한안과학회 2005 대한안과학회지 Vol.46 No.11
Purpose: Recent studies suggest that increased expression of the vascular endothelial growth factor (VEGF) may play a role in the pathogenesis of diabetic complications. The aim of this study was to assess the potential association of VEGF gene polymorphisms with disease expression of retinopathy in patients with diabetes mellitus. Methods: We studied 96 diabetic patients to determine whether there is an association between diabetic retinopathy in VEGF and VEGFR gene; all patients were unrelated Korean individuals (PDR, n=32; NPDR, n=25; no DMR, n=39). We analyzed VEGF and VEGFR SNP by restriction fragment mass polymorphism (RFMP). PCR was performed with primers designed to introduce a type IIS restriction endonuclease recognition sequence (FokI, BstF5I) ahead of the polymorphism site. The enzymatic cleavage of the products resulted to excision of two oligonucleotide fragments containing the variation site, and then masses of the resulting oligonucleotide fragments were examined by matrix assisted laser desorption time of flight mass spectrometry (MALDI-TOF MS). Difference are seen as the presence, absence, or mass change in peaks corresponding to the fragments affected by existence of polymorphism that have base substitution at the site of variation. Results: We found that the genotype frequencies of two polymorphisms shown to be completely linked to each other (rs3025039; vf1, rs3025040; vf2) and one polymorphism (rs3812867; vfr1) within 3`-untranslated regions (3`-UTR) of the VEGF and VEGFR1 significantly differed between patients with and without retinopathy. The frequencies of the vf1, vf2 and vfr1 did not differ significantly between the NPDR and PDR group Conclusions: These data implicate the polymorphisms in the 3`-UTR of the VEGF and VEGFR1 genes as risk factors for diabetic retinopathy.
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수명곡선을 활용한 폐일반냉장고 발생량 추정방법 개발 적용에 대한 연구
김현경,변석호,김승도 한국폐기물자원순환학회 2015 한국폐기물자원순환학회지 Vol.32 No.8
This paper applied a new methodology to estimate the generation rate of waste refrigerator using Population Balance Model as well as assigning Weibull Distribution Function as probability distribution function (PDF) of lifespan. In order to determine the generation rate of waste refrigerator, it is necessary to estimate yearly sales quantity of new refrigerator and lifespan PDF of refrigerator. The average lifespan of refrigerator is determined to be 16.8 years as a result of averaging the lifespans of 4,682 waste refrigerators. We also developed a methodology to calibrate the PDF of lifespan of waste refrigerator. The generation rate of waste refrigerator in 2014 is estimated to be 1,822,633 decreasing sharply with time. The new methodology developed here can be applied to estimate the generation rates of other e-wastes.
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박서진,변석호,이준원 대한안과학회 2020 대한안과학회지 Vol.61 No.8
Purpose: To describe a case of acute retinal necrosis with clinical features of orbital inflammation. Case summary: A 33-year-old female presented with right eye injection, chemosis, and pain. At the first visit, the uncorrected visual acuity and intraocular pressure of her right eye were 20/20 and 20 mmHg, respectively. Slit-lamp examination showed inflammatory cell 2+ in the anterior chamber of the right eye; an evaluation of the peripheral retina was not conducted. The next day, computed tomography (CT) was performed due to aggravation of the orbital inflammation. High-dose intravenous methylprednisolone injection was initiated on the finding of posterior scleritis with orbital inflammation on CT scans; peripheral retinal necrosis and obstructive vasculitis were also noted. Clinically determined to be acute retinal necrosis, the patient began systemic antiviral therapy. A diagnostic anterior chamber paracentesis was positive for herpes simplex virus type 2 by polymerase chain reaction. The patient was treated with intravenous acyclovir and intravitreal injections of foscarnet, as well as barrier laser therapy. After two weeks of treatment, the patient was discharged with oral valacyclovir. During the three months of follow-up, the visual acuity of the right eye was hand motion, due to chronic optic disc swelling with chronic macular edema and macular degeneration. Neither eye showed retinal lesion progression. Conclusions: Rarely, acute retinal necrosis is accompanied by clinical manifestations of orbital inflammation. Therefore, if patients have uveitis with orbital inflammation, it is important to consider the possibility of acute retinal necrosis and to examine the peripheral retina carefully. 목적: 안와염증 증상으로 내원하여 급성망막괴사로 진단된 사례를 경험하였기에 이를 보고하고자 한다. 증례요약: 33세 여자 환자가 우안 충혈, 결막부종 및 통증을 주소로 본원 내원하였다. 내원 당시 우안 나안시력 1.0, 전방 내 염증세포는 2+로 관찰되었으며, 포도막염 및 안와염증을 동반한 후공막염 소견으로 고용량 스테로이드 정맥주사를 시행하였다. 이후 주변부 망막괴사와 폐쇄혈관염이 관찰되면서 급성망막괴사로 판단하고, acyclovir 정맥주사를 포함한 foscarnet 유리체강내 주사, 장벽레이저술을 시행하였고, 퇴원 후에도 valacyclovir 복용하면서 경과 관찰하였다. 치료 3달째, 우안의 유리체혼탁, 만성 시신경부종 및 허혈성 변화, 황반부의 변성 및 만성 부종으로 우안 시력은 안전 수동이나, 양안 새로운 병변의 발생 없이 안정적으로 유지되고 있다. 결론: 드물게 급성망막괴사가 안와염증의 형태를 동반할 경우 진단이 늦어질 수 있다. 따라서 안와염증 및 포도막염이 동반된 환자의 경우, 급성망막괴사의 가능성을 생각하고 주변부 망막검사를 철저히 하는 것이 필요하다.
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