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결핵성 뇌막염 진단에 있어서 뇌척수액 Adenosine Deaminase 활성도에 관한 연구
배선우(Seon Woo Bae),김원천(Won Tsen Kim),전근재(Geun Jae Jeon),성낙억(Nak Uk Sung),최경규(Kyung Gui Choi),최일생(Il Saing Choi) 대한내과학회 1988 대한내과학회지 Vol.34 No.4
N/A The prognosis of tuberculous meningitis is closely linked to the stage at which treatment is started. The cerebrospinal fluid findings, however, are often ambiguous, It has been suggested by recent investigations that ADA activities in cerebrospinal fluid may help differentiate tuberculous meningitis from aseptic meningitis. In this study, cerebrospinal fluid adenosine deaminase activities were measured in 23 cases of tuberculous meningitis, 9 cases of aseptic meningitis, 9 cases of purulent meningitis, 24 cases of miscellaneous neurologic conditions and 23 cases of normal controls. The results obtained were as follows: 1) The mean ADA activity in tuberculous meningitis was 17.39±10,34 U/L, in bacterial meningitis 7.87±8.52 U/L, in aseptic meningitis 2.83±1.92U/L, in miscellaneous neurologic conditions 2.80±5.61U/L and in control 1,09±0.51U/L. 2) The ADA activitiies in tuberculous meningitis showed significantly higher values than in other groups (P<0.001), 3) Cerebrospinal fluid ADA activities differentiated tuberculous meningitis from those with aseptic meningitis being higher than 4.5U/L in all and higher than 6.5U/L in 96% case of tuberculous meningitis, but lower than 6,5U/L in aseptic meningitis and less than 3.5U/L in normal controls. 4) In tuberculous meningitis, ADA activities showed significant correlation with protein in cerebrospinal fluid (P<0.01), but in other groups, no significant correlation with available routine parameters in cerebrospinal fluid. It is suggested that measurement of ADA activity in cerebrospinal fluid is a available test which is relatively easily performed for diagnosis of tuberculous meningitis, especially differential diagnosis with aseptic meningitis.
조직학적으로 확진한 결핵성 복막염 환자의 복수 Adenosine deaminase ( ADA ) 활성도에 관한 연구
배선우(Seon Woo Bae),진춘조(Choon Jo Jin),심영학(Young Hak Shim),신계철(Kye Chul Shin),권상옥(Sang Ok Kwon),김남동(Nam Dong Kim),차신웅(Shin Woong Cha),이광훈(Kwang Hoon Lee),장우익(Woo Ick Jang) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A Recent investigations have suggested that the measurement of ADA activities in various body fluids is useful in the diagnosis of tuberculous effusion. In this study, ascitic fluid ADA activities were measured in 18 cases of tuberculous peritonitis, 18 cases of malignant ascites and 33 cases of liver cirrhosis with ascites. The results obtained were as fallows: 1) The mean ADA activity in tuberculous peritonitis was 184.96±27.55U/L, in malignant ascites 22.35±3.10U/L and in liver cirrhosis 7.37±0.61U/L. 2) The ADA activity in tuberculous effusion was significantly higher than in the rest of the groups(p<0.001). 3) The malignant effusion show no significant difference with transudative effusion(p>0.05). 4) As a screening test for tuberculous peritonitis, the ADA activities above 50-70U/L had a sensitivity and specificity of 100%. In conclusion, the measurement of ascitic fluid ADA activity may be a simple and reliable screening test for the diagnosis of tuberculous peritonitis.
조직학적으로 확진된 복강내 악성병변에 대한 세침흡입 세포학적 검사의 진단적 가치
김남동(Nam Dong Kim),장우익(Woo Ik Chang),권상옥(Sang Ok Kwon),이광훈(Kwang Hoon Lee),배선우(Seon Woo Bae),김태승(Tae Seung Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A An ultrasound-guided percutaneous aspiration cytology was performed with a 22 G Chiba needle in 65 patients with intraabdominal malignancy confirmed by histologic diagnosis and the results were as follows: 1) Malignancy was confirmed by an exploratory laparotomy in 22 patients and by an aspiration biopsy in 43 patients. 2) The diagnostic accuracy of fine needle aspiration cytology was demonstrated in 89.1% of the patients. 3) The aspiration biopsy was diagnostic in 2 patients, even when the aspiration cytology was non-diagnostic. 4) There were no serious complications of the fine needle aspiration. In conclusion, the fine needle aspiration cytology with ultrasound guidance is safe, simple and accurate diagnostic method in the evaluation of space-occupying intra-abdominal malignancy. Histologic examination of tissue fragment obtained from the aspirated material appear to increase the yield of malignancy on aspiration cytology.
김태승(Tai Seung Kim),권상옥(Sang Ok Kwon),이광훈(Kwang Hoon Lee),배선우(Seon Woo Bae),노병선(Byoung Seon Rhoe),정순희(soon Hee Jung) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
Familial Polyposis Coli is a rare inherited disease and has been considered a disease in which polyps are confined to the colon and rectum. Systemic studies have recently been conducted on the polyps of the extracolonic gastrointestinal tract in Familial Polyposis Coli, which suggest that the incidence of polyps may be higher than previously suspected. So it seems that Familial Polyposis Coli affects the whole gastrointestinal tract, not only the colon and rectum as believed earlier. In Korea, several cases of Familial Polyposis Coli have been reported, but in all of them, the polyps were confined to the colon and rectum. Here we are reporting one case of Familial Polyposis Coli of the entire gastrointestinal tract.
Neuroleptic Malignant Syndrome 에 동반된 급성신부전증 1 예
이광훈,최승옥,진소영,김원천,배선우,전근재 대한내과학회 1988 대한내과학회지 Vol.35 No.5
Neuroleptic malignant syndrome is characterized by muscular rigidity, hyperthermia, altered consciousness, and autonomic dysfunction, and it appears to be an idiosyncratic reaction to major tranquilizers, all of which interfere with dopamine transmission in the hypothalamus and basal ganglia of the central nervous system. Usually the syndrome develops early in the course of treatment of when the dose of the drug is increased. Acute renal failure, one of the serious complications in neuroleptic malignant syndrome, develops very rarely. Myoglobinuria, following rhabdomyolysis, is responsible for the renal impairment. We report a case of neuroleptic malignant syndrome with myoglobinemic acute renal failure after ingestion of a large amount of various antipsychotic drugs for suicide. The patient recovered after treatment by hemodialysis, administration of bromocriptine and other conservative measures.