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박희철,Shinichi Shimizu,Akio Yonesaka,Kazuhiko Tsuchiya,Yasuhiko Ebina,Hiroshi Taguchi,Norio Katoh,Rumiko Kinoshita,Masayori Ishikawa,Noriaki Sakuragi,Hiroki Shirato 연세대학교의과대학 2010 Yonsei medical journal Vol.51 No.1
Purpose: The purpose of this study is to evaluate the clinical results of treatment with a high dose of 3-dimensional conformal boost (3DCB) using a real-time tracking radiation therapy (RTRT) system in cervical cancer patients. Materials and Methods: Between January 2001 and December 2004, 10 patients with cervical cancer were treated with a high dose 3DCB using RTRT system. Nine patients received whole pelvis radiation therapy (RT) with a median dose of 50 Gy (range, 40-50 Gy) before the 3DCB. The median dose of the 3DCB was 30 Gy (range, 25-30 Gy). Eight patients received the 3DCB twice a week with a daily fraction of 5 Gy. The determined endpoints were tumor response, overall survival, local failure free survival, and distant metastasis free survival. The duration of survival was calculated from the time of the start of radiotherapy. Results: All patients were alive at the time of analysis and the median follow-up was 17.6 months (range, 4.9-27.3 months). Complete response was achieved in nine patients and one patient had a partial response. The 1- and 2-year local failure free survival was 78.8% and 54%, respectively. The 1- and 2-year distant metastasis free survival was 90% and 72%, respectively. Late toxicity of a grade 2 rectal hemorrhage was seen in one patient. A subcutaneous abscess was encountered in one patient. Conclusion: The use of the high dose 3DCB in the treatment of cervical cancer is safe and feasible where intracavitary brachytherapy (ICBT)is unable to be performed. The escalation of the 3DCB dose is currently under evaluation.
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박희철,김종필,박근호 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
화학물질에 대한 규제가 강화되고 있는 세계적인 추세에 따라 UN에서는 2020년까지 화학물질 최소화를 목표로 하는 SAICM(Strategic Approach to International Chemicals Management) 채택을 권고하고 있다. 대내적으로 가습기 살균제사고 (2011년), 구미 불소누출사고(2012년)등 연이은 화학사고와 미지의 화학물질 유해성으로부터 건강 및 환경의 보호성이 대두되어, 화학물질 등록 및 평가에 관한 법률 (이하 화평법)과 화학물질 관리법(이하 화관법)이 ’15년 1월부터 시행되었다. 화평법은 신규 화학물질 및 연간 1t 이상 제조ㆍ수입되는 기존 화학물질에 대해 유해성 심사를 의무화하여 시장 유통 전 등록을 통한 사전 예방적 화학물질 관리를 강화하고, 화관법은 시장 내 유통되는 화학물질의 안전한 취급을 통해 사고예방 및 대응을 목적으로 제ㆍ개정되었다. 이러한 법은 국민의 건강과 환경보호를 위해 필요한 사항임에도 불구하고 기업에 경제적 부담과 더불어 국내 제조업의 생산활동에도 영향을 줄 수 있기 때문에 우려의 목소리가 있는것도 사실이다. 이와 관련하여 본 사업장 실행사례에서는 화평법ㆍ화관법에 대한 이해를 돕고, 기업의 차원에서 원활한 법규 대응을 위해 신규물질 환경성 검토, 화학물질 인벤토리 작성, 관계자(연구,구매, 개발 등)교육 및 대응방안 등에 대하여 사업장에서 법규를 이행하는데 손쉬운 접근방법을 제시하고자 한다.
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Homogenization for fissured medium equations
박희철 충청수학회 2008 충청수학회지 Vol.21 No.1
We introduce the homogenized dierential systems forssured medium equations representing the small temperature vari-ation or densities of a uid in a system consisting of two compo-nents.
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Incompressible Navier-Stokes equations inheterogeneous media
박희철 충청수학회 2006 충청수학회지 Vol.19 No.4
The homogenization of non-stationary Navier-Stokesequations on anisotropic heterogeneous media is investigated. Theeective coecients of the homogenized equations are found. Itis pointed out that the resulting homogenized limit systems areof the same form of non-stationary Navier-Stokes equations withsuitable coecients. Also, steady Stokes equations as cell problemsare identied.A compactness theorem is proved in order to deal with timedependent homogenization problems.
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박희철 대한의사협회 2013 대한의사협회지 Vol.56 No.11
The role of radiotherapy in practice is mainly palliative. According to the Practice Guidelines for Management of Hepatocellular Carcinoma (2009) developed by the Korean Liver Cancer Study Group and the National Cancer Center, Korea, radiotherapy can be applied for 1)refractoriness to trans-catheter hepatic arterial chemo-embolization, 2) portal vein tumor thrombosis,and 3) palliative therapy to reduce the symptoms caused by hepatocellular carcinoma. Radiotherapy is one of the most rapidly developing fields of medical research. Recent advances in intensity-modulated radiotherapy, image-guided radiotherapy, and respiratory-gated radiotherapy technologies have enabled more accurate and precise radiation delivery for the treatment of hepatocellular carcinoma. Proton therapy is also emerging as a candidate therapy for ablative measures for patients ineligible for other curative local therapies. Due to recent advances in radiotherapy technologies, radiotherapy for hepatocellular carcinoma has been evolving into stereotactic ablative radiotherapy, which delivers an ablative dose of radiation in 1 to 4sessions. Clinical series have confirmed that it is safe in Child-Pugh A patients and local control is sustained. The possibility for performing phase 3 randomized clinical trials involving the radiotherapy modality has increased with those advances. Not merely palliative, the role of radiotherapy in the treatment of hepatocellular carcinoma will be expanded to potentially curative therapy in patients who are ineligible for other curative local therapies.
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박희철,전홍선,김용준,양형철 대한치과재료학회 2017 대한치과재료학회지 Vol.44 No.4
This study aimed to examine the effect of phosphatidylserine-treated macrophages (THP-1) on the differentiation of human dental pulp cells. Phosphatidylserine, phosphatidylcholine, and cholesterol were mixed at a molar ratio of 2:1:1, and liposomes were produced via the vacuum evaporation method. Conditioned media (CM) were collected after treating macrophages, with liposomes for 6 and 24h, and were used for differentiating human dental pulp cells. To confirm the differentiation, we performed an evaluation of alkaline phosphatase (ALP) activity, reverse transcriptase polymerase chain reaction (RT-PCR) of dentin sialophosphoprotein (DSPP) and osteocalcin (OCN) gene expressions, and extracellular matrix mineralization assay via alizarin red S staining. There was a statistically significant increase in alkaline phosphatase activity with the conditioned medium containing 10% in the overall culture medium. RT-PCR assay revealed that conditioned media did not increase the mRNA expressions of DSPP and OCN genes. The degree of matrix mineralization was not affected by the conditioned medium. These results confirm a slight effect of the conditioned medium on the differentiation of human dental pulp cells. Future studies may adopt a method in which macrophages and human dental pulp cells are closely co-existed, to evaluate the effect of phosphatidylserine on the interaction between these cell types
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