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난소암에서 대식구 집락자극인자 , 과립구 대식구 집락자극인자와 그 수용체들의 발현
송승규,이헌영,남궁성은,김수평,한구택,류기성,류부학,박혜정,제동성 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.8
Colony-stimulating factors(CSFs) are a family of glycoprotein that are involved in the survival, proliferation, differentiation and activation of hematopoietic cells at various stages of their development. The clinical ramification and therapeutic evalutation of hematopoietic growth factors are a rapidly growing field taht holds promise for the treatment of various medical illness. Many nonhematopoietic tumors produce hematopoietic growth factor that mayinfluence cellular proliferation either by autocrine or by paracrine mechanism. So hematopoietic growth factors have been implicated in protean nonhematopoietic process. In this study, expression of macrophage colony-stimulating factor(M-CSF), M-CSF receptor(M-CSF-R), granulocyte macrophage CSF(GM-CSF) and GM-CSF receptor(GM-CSF-R)was investigated in 37 gynecologic tissues including 31 samples of malignant ovarian tumor and 6 samples of benign ovarian tumor by RNA dot blot method. We systematically examined the relationship between the expression of CSFs and their receptors and clinical disease status. The results were as follows; 1. In 31 ovarian malignincies, RNA expression of CSFs and their receptors was detected from 15 cases(48.4%) in M-CSF,20(64.5%) in M-CSF-R, 13(41.9%) in GM-CSF-R, Co-expression of M-CSF-R was found in 13 cases(41.9%) and that of GM-CSF and GM-CSF-R in 10 cases(30.3%). In 6 benign ovarian cysts, GM-CSF and GM-CSF-R expressions were not detected, but M-CSF-R expressions were detected in one case even though at very low intensity 2. CA125, the most sign tumor maker in ovarian career, was significantly elevated in the ground that expressed the M-CSF(p=0.045), but not in M-CSF-R and GM-CSF-R. 3. There were significantly high rates of RNA expression of M-CSF, M-CSF-R. GM-CSF and GM-CSF-R in poorly differentiated tumors(grade 3) compared with well and moderately differentiated tumors(p=0.001, p=0.035, p=0.005, respectively). By means of Mantel-Haenszel Chi-square analysis, the intensity of RNA expression also showed significant correlation with the histologic grades in M-CSF(p=0.041). 4. Age of patinent tumor size, pathologic diagnosis and FIGO Stage did not show any significant relation with the expression of CSFs and their receptors. This results indicate that hematopoietic growth tactor modulate tumorigenesis by autocrine and paracrine mechanisms and the expression of hematopoietic growth factor and its receptor in ovarian malignancies could coptribute to their proliferative and invasive characteristics in vivo.