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박현태,이두순,박기환 한국농촌경제연구원 2001 농촌경제 Vol.24 No.2
The pot-plants are various and have the characteristic of sensitivity to vogue. Recently Japan`s pot-plants have grown continuously due to becoming gardening. Moreover the structure of Korea`s flower exports is concentrated toward Japan. So the export potential of pot-plants toward Japan seems bright. Therefore, the structure of Japan`s flower market, and consumption preference need to be investigated in order to expand exports. If the strategy items through such investigation and analysis are exported, pot-plants growers will have an opportunity for overcoming current difficulties.
박현태,이두순 한국농촌경제연구원 2002 농촌경제 Vol.25 No.2
The structure of Korea`s vegetable seed industry has changed rapidly since the IMF financial crisis in 1997. That is, Korea`s major seed companies were merged and acquired by the multinational seed enterprises. The size of Korea`s vegetable seed market is estimated by 150 billion won, and is relatively small campare to its capacity. After all, over 50 companies compete with each other severely in the limited domestic market. In order to maintain their management balance soundly, it is necessary to break out through the seed export. This paper aims to review the situation of global seed market and to promote the scheme for enlarging vegetable seed export.
RE-05 : The effect of estradiol on adipose tissue inflammation
박현태,장항용,이경욱,김용진,신정호,허준용,김선행,김탁 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
It is known that premenopausal women have lower risks for cardiovascular disease compared to men, and this sex advantage for women gradually disappear after menopause. However, the mechanisms underlying these sex differeneces are insufficiently understood. Recent studies have demonstrated that inflammation in adipose tissue has strong impacts on cardiovascular diseases. Moreover, macrophage polarization in adipose tissue has grown to become a key player in cardio-metabolic disorder. Our aim was to investigate sex specific response of adipose tissue immune cells to high fat diet and the role of estradiol to adipose tissue inflammation We develpoed C57BL/6J male, non-ovariectomized (SHAM) female, ovariectomized female, and ovariectomized female with estradiol or aromatase inhibitor to receive a normal or high fat diet. High fat diet induced adipose tissue inflammatory markers and macrophage polarization in male mice. Female mice with intact ovary were resistant to HFD induced macrophage polarization. However, T cells (CD4, CD8), dendritic cells and macrophage polarization increased in ovariectomized femlae mice compared to SHAM group. Estradiol supplementation normalized these inflammatory changes wheareas aromatase inhibitor supplementation aggrevated these changes Macrophage polarization and B and T cells, and dendritic cell change by estrogen deficiency may play an important role in developing cardio- metabolic disorder in postmenopausal women.
癌細胞 L_(1210)의 增殖抑制에 미치는 大戟과 大黃 抽出物의 影響에 對한 硏究
朴鉉邰 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
This study is attempted to obtain basic data for the development of anticancer drug from Korean medicinal herbs, Galarhaeus pekinensis and Rheum coreanum. As a preliminary experiment, cytotoxic potencies were determined from six kinds of extract used various solvents based on their polarities. Then, the effects of incubation time, size distribution of cells, cloning efficiency, development of resistance against drugs, and stability of drug in the culture medium were. determined after treatment of chloroform extract which showed strongest activity. The experimental results obtained are summarized as follows. 1. The doubling time of L_(1210) cells used in this experiment was about 11 hours. 2. The cytotoxic activity of chloroform extract of Rheum coreanum(l unit=0. 009mg) was more active than the extract of Galarhaeus pekinensis(l unit=0.013mg). 3. The cytotoxic activities of Galarhaeus pekinensis and Rheum coreanum were shown highest within 12 hours during incubation, and then the activities were gradually decreased. 4. The peak of size distribution curve shifted from 240 c.m to 60 c.m when L_(1210) cells incubated with each chloroform extract. 5. The viability of L_(1210) cells was lost completely or above 90% within 5 hours when incubated in media containing 5 unit of Galarhaeus pekinensis or 2 unit of Rheum coreanum. 6. The stability of each extract in the culture medium decreased during incubation and resistance of L_(1210) cells against drugs observed somewhat when the cells mere treated with same concentration of drugs after medium change.
Ovarian Hyper-Response to Administration of an GnRH-Agonist Without Gonadotropins
박현태,배효숙,김탁,김선행 대한의학회 2011 Journal of Korean medical science Vol.26 No.10
Several case reports have indicated that a small subgroup of patients may develop ovarian hyperstimulation following the administration of gonadotropin-releasing hormone agonists (GnRHa) without gonadotropins. However, since only few such cases have been published,it is unclear what course to follow in subsequent cycles after ovarian hyperstimulation in the first cycle using only GnRHa. A 33-yr-old woman was referred to in vitro fertilization for oocyte donation. A depot preparation (3.75 mg) of tryptorelin without gonadotropins induced ovarian multifollicular enlargement with high estradiol level, and was followed by human chorionic gonadotropin administration and oocyte retrieval. In a subsequent cycle of the same patient, a low dose of tryptorelin (0.05 mg) did not induce ovarian hyperstimulation, and resulted in clinical pregnancy. This report shows potential management of ovarian hyperstimulation following the administration of GnRHa without gonadotropins.
Mannitol 投與에 依한 Na 及 水分의 排泄에 對하여
朴鉉邰,洪世鎔 고려대학교 의과대학 1976 고려대 의대 잡지 Vol.13 No.1
During the infusion of 20% mannitol, free water reasorption and osmolar clearance were studied in 15 normal man who were admitted to the department of Intermal Medicine, Woo Sok hospital, College of Medicine, Korea University from January to September, 1975. The result obtained were as followings. 1. Urine volume was increased by the infusion of mannitol. 2. The amount of excreted sodium and the rate of sodium excretion were increased by the infusion of mannital but none of them were influenced by GFR and the level of serum sodium. 3. Free water reabsorption and osmolar clearance were increased by the infusion of mannitol. 4. The slope of the increment of free water reabsorption and osmolar clearance during mannitol diuresis was significant.