P/M Fecralloy의 성형성 및 전기저항특성 향상에 관한 연구

박진우,고병현,정우영,박동규,안인섭,Park, Jin-Woo,Ko, Byung-Hyun,Jung, Woo-Young,Park, Dong-Kyu,Ahn, In-Shup 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.6

The Fe-Cr-Al alloy system shows an excellent heat resistance because of the formation of an $Al_2O_3$ film on the metal surface in an oxidizing atmosphere at high temperatures up to $1400^{\circ}C$. The Fecralloy needs an additive that can act as a binder because of its bad compactability. In this study, the green compacts of STS434L and Al powder added to Fecralloy are oxidized at $950^{\circ}C$ for up to 210 h. Fecralloy and Al is mixed by two types of ball milling. One is vented to air and the other was performed in a sealed jar. In the case of Al addition, there are no significant changes in the electrical resistance. Before the oxidation test, Al oxides are present in the Fecralloy surface, as determined from the energy dispersive spectroscopy results. The addition of Al improves the compactability because of an increased density, and the addition of STS434L increases the electrical resistivity by forming a composite oxide.

P/M Fecralloy 성형체의 고온산화 및 전기저항 안정성에 미치는 SiO₂ 첨가 효과

박진우,옥진욱,정우영,박동규,안인섭,Park, Jin-Woo,Ok, Jin-Uk,Jung, Woo-young,Park, Dong-kyu,Ahn, In-Shup 한국분말야금학회 2017 한국분말재료학회지 (KPMI) Vol.24 No.4

A metallic oxide layer of a heat-resistant element contributes to the high-temperature oxidation resistance by delaying the oxidation and has a positive effect on the increase in electrical resistivity. In this study, green compacts of Fecralloy powder mixed with amorphous and crystalline silica are oxidized at $950^{\circ}C$ for up to 210 h in order to evaluate the effect of metal oxide on the oxidation and electrical resistivity. The weight change ratio increases as per a parabolic law, and the increase is larger than that observed for Fecralloy owing to the formation of Fe-Si, Fe-Cr composite oxide, and $Al_2O_3$ upon the addition of Si oxide. Si oxides promote the formation of $Al_2O_3$ and Cr oxide at the grain boundary, and obstruct neck formation and the growth of Fecralloy particles to ensure stable electrical resistivity.

타당성 평가가 보완된 모델 운용상의 전투실험 모의분석 절차 연구

박진우,김능진,강성진,서혁,Park, Jin-Woo,Kim, Nung-Jin,Kang, Sung-Jin,Soo, Hyuk 한국시뮬레이션학회 2010 한국시뮬레이션학회 논문지 Vol.19 No.4

Currently, our society has been changed from the industrial society to the information society. As the war progresses to Information Warfare, Network-Centric Warfare, Long-Range Precision Engagement and Robot Warfare, the military should advance to High-tech Scientific force. For this creation of the war potential, it is regarded as the warfighting experiment is a critical method. Surely it is rational that LVC(Live Virtual Constructive simulation) is desirable to make the warfighting experiment. But because it is limited by the cost, the time, the place and the resource, the constructive simulation(M&S : Modeling&Simulation) is a good tool to solve those problems. There are some studies about the evaluation process for developing the model, but it is unsatisfying in the process of the constructive simulations' operation. This study focuses on the way of constructive simulation operation, which is supplied with the evaluation process(VV&A : Verification Validation & Accreditation). We introduce the example of the rear area operation simulation for "appropriateness evaluation to the organization of logistic corps" by the AWAM(Army Weapon Analysis Model). This study presents the effective methods of the constructive simulations, which is based on the reliable evaluation process, so it will contribute to the warfighting experiments.

산화물 혼합상이 페라이트계 P/M스테인리스강의 고온산화 및 전기저항 안정성에 미치는 영향

박진우,고병현,정우영,박동규,안인섭,Park, Jin-Woo,Ko, Byung-Hyun,Jung, Woo-young,Park, Dong-Kyu,Ahn, In-Shup 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.3

In order to improve the high-temperature oxidation stability, sintered 434L stainless steel is studied, focusing on the effect of the addition of metallic oxides to form stable oxide films on the inner particle surface. The green compacts of Fecralloy powder or amorphous silica are added on STS434L and oxidized at $950^{\circ}C$ up to 210 h. The weight change ratio of 434L with amorphous silica is higher than that of 434L mixed with Fecralloy, and the weight increase follows a parabolic law, which implies that the oxide film grows according to oxide diffusion through the densely formed oxide film. In the case of 434L mixed with Fecralloy, the elements in the matrix diffuse through the grain boundaries and form $Al_2O_3$ and Fe-Cr oxides. Stable high temperature corrosion resistance and electrical resistivity are obtained for STS434L mixed with Fecralloy.

SOFM 자력등화를 이용한 와이브로 시스템 설계 방법

박진우,엄기환,Park, Jin-Woo,Eom, Ki-Hwan 한국정보통신학회 2008 한국정보통신학회논문지 Vol.12 No.9

와이브로는 OFDMA/TDD (Orthogonal frequency division multiple access/Time division duplexing) 기술을 기반으로하는 고속 이동 인터넷 표준이고, IEEE802.16e 무선 MAN 표준 통합 버전의 하나이다. 본 논문에서는 SOFM 자력등화를 이용한 와이브로 시스템의 설계 방법을 제안하였다. 제안한 설계 방법은 Broadband 16 QAM 와이브로 시스템 수신단에 Bussgang 알고리즘을 이용한 SOFM 신경망 자력등화를 사용한다. 제안한 설계 방법의 유용성을 확인하기 위하여 MSE와 BER에 대하여 시뮬레이션 하였으며, 시뮬레이션 결과 제안한 SOFM 자력등화를 이용한 와이브로 시스템의 등화 성능은 기존의 와이브로 시스템보다 개선되었음을 확인하였다. WiBro(Wireless Broadband Internet) is the standard of high-speed portable internet based on OFDMA/TDD techniques, and the subset of consolidated version of IEEE802.16e Wireless MAN standard. In this paper, we propose the design method of WiBro system using the SOFM Blind Equalization. Proposed design method used SOFM neural network blind equalization with Bussgang algorithms in the Broadband 16 QAM WiBro system receiver. To verificate the proposed design method usability, the MSE and the BER are simulated. The simulation results shown that is improved the equalization performances of the proposed WiBro system using the SOFM Blind equalization than the existing WiBro system.

Studies on the Anticoagulation Process (Fibrinolysis) by Urokinase I. Purification and Characterization of Urokinase from Human Urine

박진우,이현재,김수자,Park, Jin-Woo,Lee, Hyun-Jae,Kim, Soo-Ja 생화학분자생물학회 1980 한국생화학회지 Vol.13 No.3

Urokinase는 비활성 혈장단백질인 프라스민 전구체를 활성화시키는 효소로서, 이 효소반응의 산물인 프라스민이 혈류의 응혈요소인 피브린 가수분해 과정에 참여될 수 있음으로 이 효소, 즉 Urokinase가 지닌 특성을 연주 검토하였다. 효소 시료의 정제는 ECTEOLA 수지에 의한 이온 교환 크로마토그래피 방법과 알지닌 또는 아그마틴을 ligand로 하는 친화성 크로마토그래피 방법을 도입하여 약 60배의 정제도를 얻었으며 이 경우 효소의 비활성도는 약 1,300 units/mg protein 이였다. 효소의 특성 중 특기할만한 사실은 기질 특성으로서, 다른 단백질 분해 효소인 trypsin과 작용은 비슷하나 프라스민 전구체인 프라스민노젠에만 특이하게 작용함을 알았으며 효소활성도의 최적 pH와 최적온도 등에 있어서도 다른 유사단백질 분해효소들과 다름을 알았다. 그 밖의 효소 특성인 기질에 대한 친화력 및 저해제에 의한 결과 등을 토대로 이 효소가 지난 생리적 역할, 즉 피브린 가수분해 조절기능에 대하여도 검토하여 보았다. The activation of plasminogen to an active fibrinolytic enzyme, plasmin, was studied withe urokinase(EC 3.4.26.99). A crude form of urokinase obtained from human urine was purified partially by an ion exchange column of ECTEOLA and further by an affinity column employing arginine or agmatine as a ligand on Sepharose 4B matrix. The specific activity of the final enzyme preparation was about 1,300 units per ㎎ protein based on the caseinolytic assay measuring the rate of casein hydrolysis by plasmin formed. The mode of the enzyme action seems to be similar to that of trypsin in term of the esterase activity, but the enzyme is found to be very specific toward plasminogen as the substrate. Characteristic properties of the enzyme including molecular weight, pH and temderature optimum, and some kinetic properties were studied and compared with that of the other proteolytic enzyme of trypsin and plasmin. In addition, based on its associative properties, the nature and the physiological role in the fibrinolysis were also discussed.

Sr_1-xBa_xAl₂O₄:Eu²⁺, Dy³⁺계 축광성 형광체의 합성과 그의 발광특성

박진우,김정식,Park, Jin-Woo,Kim, Jung-Sik 한국세라믹학회 2006 한국세라믹학회지 Vol.43 No.6

In this study, the $Sr_{1-x}Ba_{x}Al_{2}O_{4}:Eu^{2+},Dy^{3+}$ phosphor were prepared by the solid-state reaction method and its photoluminescence properties were investigated. Starting powders of $SrCO_3,\;BaCO_3,\;and\;Al_{2}O_3$ were mixed with $Eu_{2}O_3$ as activator, $Dy_{2}O_3$ as co-activator and $B_{2}O_3$ as flux. Then, the mixed powders were heated at the temperature of $1100{\sim}1400^{\circ}C$ for 3 h under the reducing ambient atmosphere of $95%Ar+5%H_2$. The effect of Ba addition from 0.0 to 1.0 mol on photoluminescence was investigated. As the amount of Ba increased, the intensity of emission increased and the optimum long phosphorescence occurred at the amount of 0.1 mol Ba. The optimum sintering condition for long phosphorescent phosphor of $Sr_{1-x}Ba_{x}Al_{2}O_{4}:Eu^{2+},Dy^{3+}$($x=0{\sim}1.0mol$) was found at $1400^{\circ}C$. The excitation spectra showed a broad band of $250{\sim}450nm$ with maximum peak at 360 nm. The maximum peak intensity of emission spectra occurred at the range of $480{\sim}520nm$, depending on Ba content.

군집분석을 이용한 다목적 조사의 층화에 관한 연구

박진우,윤석훈,김진흠,정형철,Park, Jin-Woo,Yun, Seok-Hoon,Kim, Jin-Heum,Jeong, Hyeong-Chul 한국통계학회 2007 응용통계연구 Vol.20 No.2

본 연구는 여러 가지의 양적변수들을 조사하는 다목적, 다변량조사 표본설계에서 층화 문제를 다룬다. 다변량 층화변수를 사용하는 층화 방법으로 일변량 층화변수가 있을 때 사용하는 누적도수제곱근법을 독립적으로 여러 층화변수에 적용하는 방법, 군집분석을 이용하는 방법, 인자분석과 군집분석을 함께 이용하는 방법 등 세 가지 방법을 제시한다. 한편, 2001년 농업총조사 자료에 나타난 동 읍 면의 농기계별 보유대수 정보를 층화변수로 활용하여 세 가지 층화 방안의 효율을 실증적으로 비교하게 되는데 그 결과 인자분석과 군집분석을 함께 고려한 층화방법이 비교적 효율적인 것으로 나타났다. This paper considers several stratification strategies for multivariate and multipurpose survey with several quantitative stratification variables. We propose three methods of stratification based on, respectively, the method of cumulative frequency square root which is the most popular one in univariate stratification, cluster analysis, and factor analysis followed by cluster analysis. We then compare the efficiency of those methods using the Dong-Eup-Myun data of the holding numbers of farming machines, extracted from the 2001 Agricultural Census. It turned out that the method based on cluster analysis with factor analysis would be a relatively satisfactory strategy.

Active Site Functional Residues of Urokinase as a Plasminogen Activator

박진우,김수자,이현재,Park, Jin-Woo,Kim, Soc-Ja,Lee, Hyun-Jae 생화학분자생물학회 1983 한국생화학회지 Vol.16 No.2

In order to elucidate the mechanism of the urokinase- induced plasminogen activetion, catalytically active functional groups which involved in the active site of urokinase molecule were investigated by a series of kinetic and chemical modification experiments. Inhibition study with several lysine and arginine derivatives indicates there involves hydrophobic interaction between urokinase and plasminogen molecules. 6-Amino hexanoic acid shows an exceptional high degree inhibition. The results from a set of pH-activity profiles and several chamical modification experiments suggest there involve at lease one serine hydroxyl moiety and one histidine imidazole group in the active site of the activator urokinase for the catalytic conversion of plaminogen into plasmin. Based on the results obtained, a minimal three step mechanism of the UK-induced plasminogen activation process was proposed as a working model. Urokinase에 의한 plasminogen 활성화 반응은 urokinase-plasminogen 복합체인 acyl-중간체를 경유하는 것으로 믿어지며, urokinase 분자내 활성화 부위 작용기로서는 histidine imidazole 잔기와 serine hydroxyl가 각각 염기성 및 천핵성 촉매제로서 작용, plasminogen의 활성화 반응에 참여될 수 있음을 pH 변화에 따른 반응 속도론적 실험과 착용기에 대한 화학적 불활성화 실험을 통하여 입증할 수 있었다. 아울러 본 연구결과를 토대로 하여 urokinase에 의하여 유도되는 plasminogen 활성화 반응에 대한 3단계 반응 메카니즘도 구상 검토해 보았다.

Cellular activities of osteoblast-like cells on alkali-treated titanium surface

박진우,이덕혜,여신일,박광범,최석규,서조영,Park, Jin-Woo,Lee, Deog-Hye,Yeo, Shin-Il,Park, Kwang-Bum,Choi, Seok-Kyu,Suh, Jo-Young The Korean Academy of Periodontoloy 2007 Journal of Periodontal & Implant Science Vol.37 No.2

임플란트와 골 사이의 결합력을 증가시키기 위하여 타이타늄 표면에 변화를 주기위한 많은 연구들이 진행되고 있다. 타이타늄의 표면 구조나 미세 지지도의 변화가 임플란트에 대한 세포의 반응에 영향을 미치며, 골아 유사세포는 표면 조도가 높은 타이타늄 표면에 더 잘 부착하며, 세포외 기질의 합성과 광물화 결정이 더 잘 일어난다고 알려져 있다. 그러나 대부분의 연구들은 마이크로 단위의 미세 지지도에 대한 연구들이고 나노 단위의 미세 지지도에 대한 연구들은 미미하다. 이에 본 연구에서는 ROS 17/2.8 cell line을 이용하여 기계적 처리만한 군을 대조군으로 하여 blasting 처리한 마이크로 단위의 미세 지지도 표면과 알칼리 처리된 나노 단위의 미세 지지도 표면에 대한 골아 유사세포의 세포 부착양상, 증식 그리고 골아 유사세포의 표식인자 발현양상 등을 상호 비교하여 골아 유사세포에 미치는 영향을 관찰하고자 하였다. SEM을 이용한 미세 지지도 관찰에서 알칼리 처리군에서는 약 200mm의 초미세 다공성의 양상을 나타내었고, blasting 처리한 군에서는 $10\;{\mu}m$ 이하의 움푹 파인 양상을 보였다. 표면조도 측정에 있어서는 blasting 처리한 군에서 기계적 처리와 알칼리 처리된 군보다 더 높은 표면 조도를 보였으며 이는 통계학적으로 유의한 차이를 나타내었다 (p<0.01). 표면결정성 분석에서는 알칼리처리 군에서 anatase와 rutile결정형이 보였으나, blasting 처리한 군과 기계적 처리 군에서는 관찰되지 않았다. 골아 유사세포 1시간 배양 후의 전자현미경 관찰에서 모든 군의 세포는 부착 및 전개 과정을 보였고, 3시간 배양에서는 모든 군의 세포가 더 많이 전개되었으나, blasting 처리한 군과 알칼리처리 군에서 세포가 다소 더 불규칙한 형태를 나타내었다. 24시간 배양에서는 모든 군의 세포에서 완전히 전개가 일어난 양상을 보였다. 1, 4, 7일간 세포배양 후 세포활성을 평가하기 위한 MTT assay에서는 모든 군에서 시간이 증가함에 따라 세포수가 증가하였으며, 1일째에 blasting 처리한 군과 알칼리처리 군에서 기계적 처리 군에 비해 세포활성도가 통계학적으로 유의한 증가를 보였다(p<0.01). 골아 유사세포 표식인자인 osteopontin, alkaline phosphatase, ${\alpha}\;1(1)$ collagen의 유전자 발현양상을 관찰해 본 결과, osteopontin, alkaline phosphatase, ${\alpha}\;1(1)$ collagen의 유전자 발현양상이 세 군 모두에서 유의한 차이는 관찰할 수 없었으나, blasting 처리한 군과 알칼리처리 군에서 기계적 처리 군에 비해 유전자 발현양상이 다소 증가하는 경향을 보였다. 결론적으로 blasting 처리한 마이크로 단위의 미세 지지도 표면과 알칼리 처리된 나노 단위의 미세 지지도 표면이 기계적 처리 군에 비해 골아 유사세포의 기능을 촉진시키나, 알칼리 처리된 나노 단위의 미세 지지도 표면은 blasting 처리한 마이크로 단위의 미세 지지도 표면이 골아 유사세포의 기능에 미치는 영향을 압도하지는 않는 것으로 사료된다. To improve osseointegration at the boneto-implant interface, several studies have been carried out to modify titanium surface. Variations in surface texture or microtopography may affect the cellular response to an implant. Osteoblast-like cells attach more readily to a rougher titanium surface, and synthesis of extracellular matrix and subsequent mineralization were found to be enhanced on rough or porous coated titanium. However, regarding the effect of roughened surface by physical and mechanical methods, most studies carried out on the reactions of cells to micrometric topography, little work has been performed on the reaction of cells to nanotopography. The purpose of this study was to examme the response of osteoblast-like cell cultured on blasted surfaces and alkali treated surfaces, and to evaluate the influence of surface texture or submicro-scaled surface topography on the cell attachment, cell proliferation and the gene expression of osteoblastic phenotype using ROS 17/2.8 cell lines. In scanning electron micrographs, the blasted, alkali treated and machined surfaces demonstrated microscopic differences in the surface topography. The specimens of alkali treatment had a submicro-scaled porous sur-face with pore size about 200 nm. The blasted surfaces showed irregularities in morphology with small(<10 ${\mu}m$) depression and indentation among flatter-appearing areas of various sizes. Based on profilometry, the blasted surfaces was significantly rougher than the machined and the alkali treated surfaces (p<O.01). On the x-ray diffraction analysis, anatase and rutile($TiO_2$) were observed on alkali treated surfaces, whereas not observed on machined and blasted surfaces. The attachment morphology of cells according to time was observed by the scanning electron microscope. After 1 hour incubation, the cells were in the process of adhesion and spreading on the prepared surfaces. After 3 hours, the cells on all prepared surfaces were further spreaded and flattened, however on the blasted and alkali treated surfaces, the cells exhibited slightly irregular shapes and some gaps or spaces were seen. After 24 hours incubation, most cells of the all groups had a flattened and polygonal shape, but the cells were more spreaded on the machined surfaces than the blasted and alkali treated surfaces. The MTT assay indicated the increase on machined, alkali treated and blasted surfaces according to time, and the alkali treated and blasted surfaces showed significantly increased in optical density comparing with machined surfaces at 1 day (p<0.01). Gene expression study showed that mRNA expression level of ${\alpha}\;1(I)$ collagen, alkaline phosphatase and osteopontin of the osteoblast-like cells showed a tendency to be higher on blasted and alkali treated surfaces than on the machined surfaces, although no siginificant difference in the mRNA expression level of ${\alpha}\;1(I)$ collagen, alkaline phosphatase and osteopontin was observed among all groups. In conclusion, we suggest that submicroscaled surfaces on osteoblast-like cell response do not over-ride the one of the surface with micro-scaled topography produced by blasting method, although the microscaled and submicro-scaled surfaces can accelerate osteogenic cell attachment and function compared with the machined surfaces.