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총명탕(聰明湯)과 목근피총명탕(木槿皮聰明湯)이 CT105와 ${\beta}A$로 유도된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향
박지운,정인철,이상룡,Park, Ji-Un,Jung, In-Chul,Lee, Sang-Ryong 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.1
Objective : This research investigates the effect of the CMT and MCMT on Alzheimer‘s disease. Methods : The effects of the CMT and MCMT extract on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, GFAP, CD68 abd CD11b; (5) the infarction area of the hippocampus in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Results : 1. The CMT and MCMT extract suppressed the expression of APP, AChE, and mRNA in PC-12 cells treated with CT-105. 2. The CMT and MCMT extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and MCMT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and MCMT extract suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, GFAP, CD68 abd CD11bCD68/GFAP, in the mice with Alzheimer's disease induced by ${\beta}A$. 5. The CMT and MCMT extract reduced the infarction area of hippocampus with Alzheimer's disease induced by ${\beta}A$ 6. The MCMT showed more excellent effects than CMT in the every experiments except PC-12 cells. Conclusions : These results suggest that the CMT and MCMT extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CMT and MCMT extract for Alzheimer's disease is suggested for future research.
총명탕(聰明湯)과 목근피총명탕(木槿皮聰明湯)이 CT105와 βA로 유도된 Alzheimer`s Disease 병태(病態) 모델에 미치는 영향
박지운 ( Ji Un Park ),정인철 ( In Chul Jung ),이상룡 ( Sang Ryong Lee ) 대한한방신경정신과학회 2006 동의신경정신과학회지 Vol.17 No.1
Objective: This research investigates the effect of the CMT and MCMT on Alzheimer`s disease. Methods : The effects of the CMT and MCMT extract on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11b; (5) the infarction area of the hippocampus in Alzheimer`s diseased mice induced with βA were investigated. Results : 1. The CMT and MCMT extract suppressed the expression of APP, AChE, and mRNA in PC-12 cells treated with CT-105. 2. The CMT and MCMT extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and MCMT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and MCMT extract suppressed the over-expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11bCD68/GFAP, in the mice with Alzheimer`s disease induced by βA. 5. The CMT and MCMT extract reduced the infarction area of hippocampus with Alzheimer`s disease induced by βA. 6. The MCMT showed more excellent effects than CMT in the every experiments except PC-12 cells. Conclusions : These results suggest that the CMT and MCMT extract may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the CMT and MCMT extract for Alzheimer`s disease is suggested for future research.
조동백,박지운,백지영,최원식,Cho, Dong-Baek,Park, Ji-Un,Baek, Ji-Young,Choi, Won-Sik 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.6
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign vascular lesion that is characterized by proliferation of small to medium-sized vascular structures lined by histiocytoid or epithelioid endothelial cells and often accompanied by an inflammatory infiltrate comprising lymphocytes, plasma cells and eosinophils. A 34-year-old man without any generalized systemic conditions presented with a slowly enlarging painless swelling in the buccal area. An excisional biopsy was conducted and the diagnosis of Angiolymphoid hyperplasia with eosinophilia was confirmed. We report a case of angiolymphoid hyperplasia with eosinophilia of the buccal area in oral cavity and review the previously reported cases and literatures of angiolymphoid hyperplasia with eosinophilia.
적층제조용 고분율 γ′ 초내열합금의 성분설계 및 고온변형 거동 고찰
홍현욱(Hyun-Uk Hong),박지운(Ji-Un Park),이병수(Byoung-Soo Lee),이해진(Hae-Jin Lee) 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.5
Ni기 초내열합금은 L12 규칙격자 γ′-Ni3(Al,Ti) 석출상의 분율이 높을수록, 전위의 움직임을 효과적으로 방해하여 고온강도와 크리프 특성이 우수해지나, 용접성은 불리해진다. 용접시 급열 이후 고온에서 냉각하는 동안에 석출 kinetics가 매우 높은 γ′이 다량 석출되어 수축하고 이로 인해 인장 잔류응력이 발생하여 고온균열 (응고균열, 액화균열 등)이 발생하기 쉽기 때문이다. 용접과 물리적인 현상이 동일한 분말 적층제조 역시 용접성이 좋지 않으면 적층제조 용이성도 좋지 않다. 이러한 이유로 현재까지 γ′ 분율이 20% 이하로 낮은 초내열합금들 (Inconel 718, 625 등)에 대해 적층제조 연구가 주로 이루어졌다. 하지만, 가스터빈의 온도를 높여 효율을 향상시키기 위해서는 고온 크리프 특성이 우수한 고분율 γ′ 합금들의 적층제조 연구가 중요하게 고려되고 있다. 본 연구에서는 전자 빔 용해(Electron Beam Melting, EBM) 방식을 사용해 γ′ 강화상 분율이 40%이상 높은 René 80을 reference합금으로 적층제조를 시도하였다. 넓은 범위의 EBM 조건에서 적층제조를 하더라도, arc blowing 현상과 심각한 고온균열 발생으로 20mm 높이 이상으로 적층이 불가능하였다. 이에 본 연구에서는 대규모 열역학 계산 방식을 접목하여, 고온강도는 René 80급 동등이상으로 확보하면서 적층제조 용이성을 크게 향상시키는 맞춤형 합금설계를 도출하였다. 기존 René 80 성분의 기준선에서 Ti 감소 (5 → 3 wt %), 2.5 wt % Ta 첨가 및 1.0 wt % Hf 첨가는 균열없는 EBM 제조뿐만 아니라 더 나은 분말 특성 (구형에 더 가까운)을 얻는데 성공하였다. 표준 열처리된 EBMed 부품은 870℃에서 기존 주조 제품에 비해 우수한 인장 특성을 나타내었다. Primary γ ‘는 a / 3<112> 부분 전위에 의해 전단되어 적층 결함을 남기고, 50nm 미만의 미세한 secondary γ’와의 강한 상호 작용의 결과로 높은 밀도의 tangled 전위들이 관찰되어, 우수한 고온 인장특성을 잘 반영해 준다.
震顫을 主 症狀으로 入院한 患者 30例에 對한 臨床的 考察
朴智雲,李相龍 대전대학교 한의학연구소 2001 혜화의학회지 Vol.10 No.1
The clinical study was carried out the 30 patients with tremor who were treated in Daejeon University Oriental Hospital from 1 April 1997 to 31 March 2001. The results were summarized as follows. 1. The ratio of female was higher, especially in the psychosomatic tremor, the ratio of female was higher and in the age distribution the aged over 50 were higher frequence. 2. The case without past history was most, the most ordinary preceding disease was hypertintion and the next was diaetes, dringking history had no concern with tremor, first visit was msot, in the psychosomatic tremor complicaiton by relation was the most inducing factor and both parkinson tremor and essential tremor were no inducing factor. 3. Tremor appeared to be busy in extremities, parkinson tremor appeared to be accompanied with musculoskeletal system symptoms and they were in descending order lower limb weakness, extremities numbness, general body weakness e.t.c. both essential trmor and psychosomatic tremor appeared to be accompanied with psychosomatic symptoms and they were in descending order dizziness, headache e.t.c. 4. In classification of Four Human coporeal constitution the number of patients, Tae-Eum-In(太陰人) was most, the prescription drugs of tranquillizing the liver and relieving anxiety such as GYEJIYONGGOLMORYETANG(桂枝加龍骨牡蠣湯) and nourishing Yin, blood and relieving anxiety such as SAMULANSINTANG(四物安神湯) were used to be busy. 5. The rate of treatment was collectively improved and was higher in the yaung age than in the old age, the period of the clinical history was the shorter within on e month, the rate of improvement was the better