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Tympanometry를 이용한 삼출성 중이염의 임상적 관찰에 대한 연구
박외숙,윤희성,김희정,김규석,김윤범,Park, Owe-Suk,Yoon, Hui-Sung,Kim, Hee-Jeong,Kim, Keoo-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3
Objective: In order to help clinical approach on OME patient in progress observation and decision on improvement by clinical research results using tympanometry. Methods: Data was collected from 163 ears of 96 patients who were treated in Dept. of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, Kyung-Hee Medical Center from 2001-2-12 to 2005-4-29 for Otitis Media with Effusion(OME). Tympanometry was applied to all patients and the test result was used to evaluate progress and improvement. F/U cases below 3 times were excluded. Results & conclusion: 1. Age and sex distribution was as follows: Mean Age 5.5years old(Standard deviation: 2.1), age distribution 2-61years old, below 10years old 151cases(92.6%) and above 10years old 12cases(7.4%). Male and female ratio was 1.81:1. 2. There were 67people(69.8%) with bilateral affected ear. Unilateral was 29people(30.2%). Affected ear distribution according to sex came out similarly. 3. Affected period distribution was as follows: over 12weeks 71cases(43.6%), under 12weeks 92cases(56.4%). Out of under 12weeks cases, 2-4weeks was 34cases(20.9%), 0-1weeks and 5-8weeks 20cases(12.3%), 9-12weeks 18cases(11.0%). There was evident difference about affected period between male and female. 4. All patients who served previous Tx in medical clinic(118 cases) took antibiotics. Only 6cases took tube insertion. The period of Taking antibiotics was as fellows: over 6weeks 42cases(35.6%), under 5weeks 37cases(31.4%). unknown 25cases(21.2%), jntermittent 14cases(11.9%). 5. In Period of Tx distribution, 5-6weeks showed 40cases(24.5%) which was highest number. In Improved cases(85cases), 3-4weeks and 5-6weeks each 22cases(25.9%) which was highest number. 1-2weeks 3cases(3.5%), 7-8weeks 12cases(14.1%), 9-10weeks 9cases(10.6%), 11-12weeks 10cases(11.8%), over 12weeks 7cases(8.2%). 6. The cases which have gastrointestinal Sx were 71cases(43.6%), the others 92cases(56.4%). Details of gastrointestinal Sx were as follows: Sx associated with appetite 47cases(47.5%), constipation 15cases(15.2%), abdominal pain and diarrhea 14cases(14.1%), frequent vomitting Teases(7.1%), etc 4cases(4.0%). 7. The cases which have accompanying disease were 116case(71.2%), the other 47cases(28.8%). Details a accompanying disease were as follows: sinusitis 57cases(35%), rhinitis 55cases(3.7%), allergic rhinitis 20cases(12.3%), atopic dermatitis 19cases(1.7%), urticaria 4cases(2.5%), asthma 3cases(1.8%), nasal polyp and conjunctivitis 2cases(1.2%) each, laryngitis 1case(0.6%).
가토(家兎)의 녹농균성 부비동염에 대한 백반(白礬)의 항염증(抗炎症) 효과
박외숙,김희정,김규석,차재훈,김윤범,Park, Owe-Suk,Kim, Hee-Jeong,Kim, Keoo-Seok,Cha, Jae-Hoon,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2006 한방안이비인후피부과학회지 Vol.19 No.1
Objective : In order to investigate anti-inflammatory effect of Alum objectively which is traditional remedy applicated by external preparation frequently, especially in Rhinologic field. Materials and Method : We studied the histopathologic and hematologic features, serum transaminase activities in the experimentally induced maxillary sinusitis in rabbits. 9 rabbits was divided into normal, control anti sample group(each 3 rabbits). We inoculated $10^{10}$ P. aeruginosa for experimental maxillary sinusitis to control group and sample group. Sample group was treated with aim solution(l0g/100cc) lcc via both nasal cavity (each 0.5cc) after 24hrs everyday for 14days. Results and Conclusion : 1. We confirmed that maxillary sinusitis was well induced by P. aeruginosa without occlusion of maxillary ostium. 2. There was no abnormal findings in serum transaminase(AST/ALT) activities even though application of Alum solution on nasal mucosa for 14days continuously. 3. Alum has evident anti-inflammatory effect of recovering mucosal surface injury, reduction of goblet cell, lymphocyte infiltration, edema and expansion of glandular tissue, dilatation and congestion of blood vessels and so on. 4. Alum has the effect that recover glandular tissue injury and decrease goblet cell increase by the result of dermal PAS staining increase and epidermal AB staining decrease in the qualitative analysis of epidermal and dermal mucopolysaccharide
박외숙 대한약학회 1984 약학회지 Vol.28 No.1
A total synthesis of dehydrojuvabione which has high juvenile hormone activity, is described. The kinetic enloate of mesityl oxide is used as nucleophilic synthon for this synthesis. 1,4-Dioxaspiro [4,5] decan-8-carboxaldehyde was treated with kinetic enolate of mesityl oxide to give 8-(1'-hydroxy-5'-methyl-3'-oxo-4'-hexenyl)-1,4-dioxaspiro [4,5] decane. The latter compound was dehydrated. The resulted dienone was treated with lithium dimethylcuprate. After that, appropriate transformation was performed to give dehydrojuvabione.
박외숙,김윤범,Park, Owe-suk,Kim, Yoon-bum 대한한방안이비인후피부과학회 2004 한방안이비인후피부과학회지 Vol.17 No.3
In clinical practice, Psoriasis is commomly difficult to be completely cured that only repeats improvement and to be worsen. We experienced one case of Psoriasis patient who had had generalized expoliative Psoriasis for more than one year. After hospitalization treatment of ten days and outpatient treatment of three months, he's chief complain improved continuously and there was not worsen sign any more. So, He could return to his usual life, We still did't know the mechanism that Saengkankunbi-Tang brought his improvement by, but we think that more case studies are necessary focusing on damp-heat because of much drinking for long time and years of duration of skin disease.