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Cilostazol attenuates kainic acid-induced hippocampal cell death
박영섭,김진,정은애,이친옥,이종열,박인성,노구섭 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade. Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol’s effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation. These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
박영섭,현승재,김기정,장태안 대한척추신경외과학회 2016 Neurospine Vol.13 No.1
Intradural disc herniation is a very rare condition, and multiple intradural disc herniations have not been reported to date. The latter may be confused with intradural extramedullary (IDEM) spinal tumors. Here, we report a case of multiple intradural disc herniations masquerading as multiple IDEM tumors and review the relevant literature. We retrospectively reviewed the patient’s medical chart, reviewed the intraoperative microscopic findings, and reviewed of PubMed articles on intradural disc herniation. The masses considered to be IDEM tumors were confirmed to be multiple intradural disc herniations. A nonenhancing mass was found to have migrated along the intra-arachnoid space. Two enhancing masses could not migrate because of adhesion and showed peripheral neovascularization. We report an extremely rare case of multiple intradural lumbar disc herniations showing diverse enhancing patterns and masquerading as multiple IDEM tumors. In case of multiple enhancing IDEM masses suspected preoperatively, surgeons should consider the possibility of intradural disc herniation.
박영섭,Park, Yeong-Seop 한국전기기술인협회 2007 電力技術人 Vol.297 No.-
1980년대 초반부터 1990년 후반 무렵까지의 건설붐의 전성기라 할 수 있다. 고도성장시대에 건설된 전기설비는 현재 노후화, 경년열화화 하여 정전사고 및 효율이 떨어져 유지 관리를 필요로 하는 전기시설물은 해를 거듭할수록 그 수가 증가하고 있다.
5상~9상까지 계속발생 - 옥수수 조명나방 발생 생태와 방제대책
박영섭 한국작물보호협회 1983 자연과 농업 Vol.4 No.8
화본과 식물에 속하며 염색체 수가 n=10개인 옥수수의 유연식물 또는 야생종으로 생각되는 식물에는 남아메리카 일부 지방에서 야생하는 부유종과 멕시코 지방의 테오신트(Teosinte grass)와 중앙아메리카에 분포하는 옥수수와 교잡이 가능하다는 가마그라스(Gamagrass)의 3종이 옥수수의 기원이라는 학설이 있다.