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박상태,김준태,김현섭,정기주 한국물리학회 2006 새물리 Vol.53 No.1
In this study, we introduce interference experiments using a scanner as an effort to improve optics experiments in education. When using a scanner, we can reduce the experimental time freatly and can get accurate data by using a photodiode or illumination meter. Also, because we can analyze the two-dimensional patterns from circle-type and H-type slits, we can show the relation between the patterns and the various types of slits. Especially, if the results of this study are used in scientific education for the gifted, it will improve the creativity for optics experiments. 본 연구에서는, 교육현장에서의 광학실험 개선을 위한 노력의 일환으로스캐너를 이용한 간섭 회절 실험을 소개하고자 한다. 스캐너를 이용할경우, 기존의 photo diode나 조도계를 이용한 실험에 뒤지지 않을 정도의정밀한 결과를 얻을 수 있음은 물론, 장시간 소요되었던 실험 시간도 한번의 스캔으로 측정이 가능하기 때문에, 실험 소요시간을 획기적으로단축할 수 있다. 또한 원형 슬릿, H자형 슬릿 등과 같은 2차원 무늬에대해서도 손쉽게 분석할 수 있어, 교육현장에서 여러 가지 슬릿에 대한간섭무늬를 학생들에게 재현해 보여줄 수 있으며, 슬릿의 모양과간섭무늬와의 관계를 스스로 확립해 나갈 수 있을 것으로 생각된다. 특히과학영재교육에 활용할 경우 광학실험에 대한 창의성을 향상시킬 수 있을것으로 생각된다.
Trends in Next-Generation Sequencing and a New Era for Whole Genome Sequencing
박상태,김자영 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.S1
This article is a mini-review that provides a general overview for next-generation sequencing (NGS) and introduces one of the most popular NGS applications, whole genome sequencing (WGS), developed from the expansion of human genomics. NGS technology has brought massively high throughput sequencing data to bear on research questions, enabling a new era of genomic research. Development of bioinformatic software for NGS has provided more opportunities for researchers to use various applications in genomic fields. De novo genome assembly and large scale DNA resequencing to understand genomic variations are popular genomic research tools for processing a tremendous amount of data at low cost. Studies on transcriptomes are now available, from previous-hybridization based microarray methods. Epigenetic studies are also available with NGS applications such as whole genome methylation sequencing and chromatin immunoprecipitation followed by sequencing. Human genetics has faced a new paradigm of research and medical genomics by sequencing technologies since the Human Genome Project. The trend of NGS technologies in human genomics has brought a new era of WGS by enabling the building of human genomes databases and providing appropriate human reference genomes, which is a necessary component of personalized medicine and precision medicine.