일개 임상시험에서 피험자 순응도에 영향을 미치는 요인 분석

박민지,나현오,김영인,김경수 대한임상약리학회 2009 Translational and Clinical Pharmacology Vol.17 No.1

Background: Due to the strong relationship between successful clinical trial result and subject's high compliance to protocol, this research aimed to provide the basic information of the key factors affecting subject's compliances to improve the quality of the clinical trial . Method: The cross sectional study was retrospectively investigated with the result of the phase III clinical trial which had been conducted with co-participation of investigators belonged to two different medical specialties involving 15 university affiliated hospitals from October 2007 to April 2009. The factors were classified into subject factor, institution factor, principal investigator factor, study staff factor and clinical research associate (CRA) factor. The collected data was tested at significance level of 5% using SAS program (Version 8.0). To investigate the correlation between subject's compliance and the suggested factors, chi-square test and multiple logistic regression analysis were tested. Specifically, stepwise multiple regression analysis was conducted to analyze the factors affecting the final subject's compliances. The data for nine subjects from two institutions which had made poor progress during the trial was excluded from the analysis. Result: Among subject's compliances, the factors affecting the visit completion and medication compliance were come out differently. In terms of the visit completion, as a result of stepwise multiple regression analysis, the rate of visit completion was 4.9 times higher in the group of subjects taking corticosteroids than others, which is significant. In addition, the rate of visit completion was 10 times and 6.5 times respectively higher with principal investigators and clinical research coordinators belonging to the department in charge of the subject enrollment with subject's underlying disease treatment than the department in charge of the tests during the clinical trial, which is significant. Particularly, in terms of medication compliance 80% of investigational product medication compliance was shown in the group of no CRA change which is 4.0007 times significantly higher than others. Conclusion: Among subject's compliances, the significantly high influential factor for the visit completion was the subjects taking corticosteroids which were one of the risk factor for peptic ulcer and the specialty factor in charge of the continuous treatment for subjects and its principal investigator. Also, the factor which had significantly highly affected subject's medication compliance was CRA factor. Since subject's compliances were limited with the visit completion and medication compliance in this study, further investigations about subject's compliance are required. Also, it will be necessary to investigate CRA's indirect influence to subject's medication compliance in detail in the future. Background: Due to the strong relationship between successful clinical trial result and subject's high compliance to protocol, this research aimed to provide the basic information of the key factors affecting subject's compliances to improve the quality of the clinical trial . Method: The cross sectional study was retrospectively investigated with the result of the phase III clinical trial which had been conducted with co-participation of investigators belonged to two different medical specialties involving 15 university affiliated hospitals from October 2007 to April 2009. The factors were classified into subject factor, institution factor, principal investigator factor, study staff factor and clinical research associate (CRA) factor. The collected data was tested at significance level of 5% using SAS program (Version 8.0). To investigate the correlation between subject's compliance and the suggested factors, chi-square test and multiple logistic regression analysis were tested. Specifically, stepwise multiple regression analysis was conducted to analyze the factors affecting the final subject's compliances. The data for nine subjects from two institutions which had made poor progress during the trial was excluded from the analysis. Result: Among subject's compliances, the factors affecting the visit completion and medication compliance were come out differently. In terms of the visit completion, as a result of stepwise multiple regression analysis, the rate of visit completion was 4.9 times higher in the group of subjects taking corticosteroids than others, which is significant. In addition, the rate of visit completion was 10 times and 6.5 times respectively higher with principal investigators and clinical research coordinators belonging to the department in charge of the subject enrollment with subject's underlying disease treatment than the department in charge of the tests during the clinical trial, which is significant. Particularly, in terms of medication compliance 80% of investigational product medication compliance was shown in the group of no CRA change which is 4.0007 times significantly higher than others. Conclusion: Among subject's compliances, the significantly high influential factor for the visit completion was the subjects taking corticosteroids which were one of the risk factor for peptic ulcer and the specialty factor in charge of the continuous treatment for subjects and its principal investigator. Also, the factor which had significantly highly affected subject's medication compliance was CRA factor. Since subject's compliances were limited with the visit completion and medication compliance in this study, further investigations about subject's compliance are required. Also, it will be necessary to investigate CRA's indirect influence to subject's medication compliance in detail in the future.

중국 남서부의 Kejie 유역을 대상으로 토지이용과 기후 변화에 따른 수문과정 변화

박민지,박근애,김성준,Park, Min-Ji,Park, Guen-Ae,Kim, Seong-Joon 한국관개배수위원회 2009 한국관개배수논문집 Vol.16 No.1

Development and validation of ultra-fast quantitative real-time PCR method to differentiate between Oncorhynchus keta and Oncorhynchus mykiss

박민지,이한철,양지영,김중범 한국식품저장유통학회 2023 한국식품저장유통학회지 Vol.30 No.3

The ultra-fast quantitative real-time polymerase chain reaction (qPCR) assay was developed and validated to differentiate the morphologically similar ones, Oncorhynchus keta and Oncorhynchus mykiss. Species-specific primers were designed for the COI genes of mtDNA. The species-specific primers designed for O. keta and O. mykiss were selectively amplified by O. keta and O. mykiss DNA, respectively. The sensitivity of O. keta and O. mykiss primers was 1 ng/μL. Quantitative testing showed that the results met the ‘Guidelines on Standard Procedures for Preparing Analysis Method such as Food’ proposed by the Ministry of Food and Drug Safety. The qPCR method developed and validated in this study for identifying O. keta and O. mykiss has advantages such as speed and field applicability. Therefore, this method is expected to help control forgery and alteration of raw materials in the seafood industry.

정신장애 영유아의 내재화 및 외현화 문제행동이 어머니의 우울증상에 미치는 영향: 아동영역 및 부모영역 양육스트레스의 이중매개효과

박민지,하은혜 한국놀이치료학회 2020 한국놀이치료학회지(놀이치료연구) Vol.23 No.1

The purpose of this study was to verify the mediating effects of parenting stress in the relationship between behavior problems of infants with mental disorders and maternal depressive symptom. The participants comprised 129 mothers who have infants at the age of 21 months to 59 months with mental disorders. The infants were diagnosed with mental disorders respectively based on Chid Behavior Checklist(CBCL 1.5-5), Beck Depression Inventory(BDI) and Parenting Stress Index(PSI). The result were as follows: First, the infants' internalizing and externalizing behavioral problems influenced maternal depressive symptoms and parenting stress. Second, the higher PSI score was shown in both Child and Parent domain, the higher Depression score was shown among mothers. Third, both scores of Parent and Child domains showed mediating effects between the independent and dependent variables. This study verified that two domains of maternal parenting stress mediated when the behavioral problems of mentally disabled infants influenced maternal depressive symptoms. 본 연구에서는 정신장애 영유아의 문제행동과 어머니의 우울증상 및 양육스트레스의 관계를 확인하고, 영유아의 문제행동이 어머니의 우울증상에 미치는 영향에서 양육스트레스의 매개효과를 검증하였다. 연구대상은 소아정신과 병원 2곳, 재활의학센터 1곳, 그리고 발달장애 클리닉 1곳에서 정신장애 진단을 받은 21개월에서 59개월 영유아 129명이었다. 연구도구는 CBCL 1.5-5 유아행동평가척도, 어머니 우울평가척도 (BDI), 그리고 양육스트레스 척도(K-PSI)를 사용하였다. 본 연구의 결과는 다음과 같다. 첫째, 정신장애 영유아의 내재화 및 외현화 문제행동은 어머니의 양육스트레스와 우울증상에 정적인 영향을 미쳤다. 둘째, 어머니 양육스트레스의 아동영역과 부모영역은 어머니의 우울증상에 영향을 미치는 것으로 나타났으며 양육스트레스의 아동 및 부모영역 수준이 증가할수록 어머니의 우울 수준도 증가했다. 셋째, 정신장애 영유아의 내재화 및 외현화 문제행동이 어머니의 우울증상에 영향을 미칠 때 어머니의 양육스트레스가 일부 원인이 된다는 점을 확인하였다. 즉, 두 문제행동은 양육스트레스의 아동영역을 통해서 부모영역에 영향을 미치게 되는 이중매개를 통해 어머니의 우울증상을 유발하였다. 이처럼 본 연구에서는 정신장애 영유아의 문제행동이 어머니의 우울증상으로 이어질 때 어머니의 양육스트레스가 일부 원인으로 작용한다는 것을 검증하였으며, 특히 양육스트레스가 매개역할을 할 때 양육스트레스의 두 영역 사이에서 경로를 나타낸다는 것을 확인했다는 점에서 의의가 있다.

Asymmetric preparation of 2,4,6-trisubstituted dihydropyridazinones

박민지,Seo Yun Kim,이하림,박용선 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.1

Modular three-component synthesis of highly enantioenriched 2,4,6-trisubstituted dihydropyridazinones was developed through the nucleophilic substitution of α-bromoacetates with silyl enol ethers and subsequent condensation with hydrazine derivatives.

리튬이온 배터리의 비선형 온도 시스템에서 NMPC를 이용한 최적화 제어

박민지,이수진,황성원 한국공업화학회 2022 한국공업화학회 연구논문 초록집 Vol.2022 No.1

에너지 분석을 통한 수소액화 공정의 최적화

박민지,황성원 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.1

Process Simulation for High Performance CO₂ Capture from Exhaust Gas and Comparative Study of Amine-based Solvent

박민지,황성원,( Gbadago Dela Quarme ) 한국공업화학회 2023 한국공업화학회 연구논문 초록집 Vol.2023 No.0

Application of the Modified CA-Markov Technique for Future Prediction of Forest Land Cover in a Mountainous Watershed

박민지,박근애,이용준,김성준,Park, Min-Ji,Park, Geun-Ae,Lee, Yong-Jun,Kim, Seong-Joon The Korean Society of Agricultural Engineers 2010 한국농공학회논문집 Vol.52 No.1

토지피복은 대부분의 수문 수질 모형의 중요한 매개변수로서, 수자원 변화 예측에 중요한 입력자료로 활용되고 있다. 본 연구에서는 개선된 CA (Cellular Automata)-Markov 기법을 이용하여 충주댐유역의 미래 산림식생변화에 대한 예측을 시도하였다. 예측과정으로 과거의 Landsat TM 영상 (1985, 1990, 1995, 2000)을 이용하여 기법의 정확도 검증 및 산림분포의 변화경향을 파악하고, Landsat 산림은 2000년과 2005년의 NOAA AVHRR NDVI값을 기준으로 침엽수림, 혼효림, 활엽수림의 3종으로 구분한 후, 이를 이용하여 2030년, 2060년, 2090년의 식생변화를 추정하는 방법을 제안하였다. 이 방법의 적용결과, 2000년과 비교하여 2090년의 활엽수림과 혼효림은 각각 14.3 %, 11.6 % 증가하였으며, 침엽수림은 24.9 % 감소하는 것으로 나타났다. 과거의 경향성에 의해 예측을 시도한 본 연구결과는 미래 토지피복 변화에 따른 수문 수질 영향 분석시 지표 조건의 불확실성을 줄이는데 활용될 수 있다고 판단된다.

Follicular Proliferative Lesion Arising in Struma Ovarii

박민지,민혜숙,김민아,신미경 대한병리학회 2015 Journal of Pathology and Translational Medicine Vol.49 No.3

Malignant struma ovarii is extremely rare and difficult to diagnose histologically, particularly in cases of follicular carcinoma. This case study is intended to describe three cases of follicular proliferative lesion arising in struma ovarii that we experienced. The first case was clearly malignant given the clinical picture of multiple recurrences, but there was little histological evidence of malignancy. Our second case featured architectural and cellular atypia and necrosis and was diagnosed as malignant despite the absence of vascular and stromal invasion. Our third case exhibited solid microfollicular proliferation without any definite evidence of malignancy (even the molecular data was negative); however, we could not completely exclude malignant potential after conducting a literature review. In cases such as our third case, it has been previously suggested that a diagnostic term recognizing the low-grade malignant potential, such as “proliferative stromal ovarii” or “follicular proliferative lesion arising in the stromal ovarii” would be appropriate.