피지선 모반에서 발생한 피지선 상피종

민형근,안규중,김종민,이일수,이종주 ( Hyung Geun Min,Kyu Joong Ahn,Jong Min Kim,Eil Soo Lee,Chong Ju Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.3

편평상피세포암에서의 극세포해리세포에 관한 병리조직학적 고찰

민형근(Hyung Geun Min),김종민(Jong Min Kim),이일수(Eil Soo Lee) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.5

Background : Squamous cell caircinoma(SCC) often shows acantholysis as a result of degenerative changes of neoplastic cells. Regurding the acantholytic changes of SCC most textbooks and literature describe the acantholysis-associated tubular or alveolar structures, which are diagnostic features of adenoid SCC. But the acantholytic changes of SCC are not always assaciated with tubular or alveolar structres. The general and detailed histologic features of acantholysis of SCC have not been reported. Objective : We analyzed the histologic features of acantholysis of SCC . Methods : Twenty six biopsy specimens from 26 patients with SCC were studied for the distributions and sites of acantholysis such as lefts and tubular or alveolar structurs on routine histologic staining. Results : All 26 biopsy specimens showed acantholysis in their tumors ocal acantholysis was found in 12 cases, and diffuse, widesprcad acantholysis was found in 14 cascs. The foci of acantholysis were in the surface epidermis in 9 cases, in the follicular wall in 5 cases, and in both the surface epidermis and the follicuar wall in 12 cases. The types of acantholytic cells were either dyskeratotic cells or non-dyskeratotic squamous cells. Tuthular or alveolar structures were found in 5 cases. Clefts were found in 12 cases, one in the subcomealarea, the other 11 were within tumor mases, and one of them showed Darier-like feature with papillary projections of neoplastic cells into thc lumens. Conclusion : The acantholytic hanges of the SCC are more comrr on y found than expected. The acantholytic changes involve not only dyskeratotic cells but also non-dysL eratotic cells and often show glandular structures and clefts. (Kor J Dermatol 1993;31(5):746-750)

옴 치료 후 사지 말단에 발생한 지속성 농포증

민형근(Hyung Geun Min),김광호(Kwang Ho Kim),민경식(Kyeong Sik Min),김종민(Jong Min Kim),이일수(Eil Soo Lee) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.5

In 1978, Bjornberg and Friis reported 32 patients with persistent pusi ulosis(PP) on distal extremities, of whom 13 patients were initially diagnosed as scabies. In 1984, Elpern described 7 patients with infantile acropustulosis(IA), of whom 4 patients had antecedant scabies. We report herein a case of PP, which was found in a 18 month-old mal who was treated for scabies at the age of 5 month and 12 month. The pruritic vesicopustules dev',lo ed 2 months after the second treatment for scabies and relapsed for 4 months. We also discuss the relationship between scabies and PP and also between PP and IA. (Kor J Dermatol 1993;31(5):751-754)

호산구성 농포성 모낭염

민형근(Hyung Geun Min),이근수(Geun Soo Lee),안규중(Kyu Joong Ahn),이종주(Chong Ju Lee) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.2

We report a case of eosinophilic pustular folliculitis in a 18-year-old woman who had numerous mild pruritic erythematous plaques with follicular papules and pustules covering almost her whole body. Histopathologically intrafollicular, perifollicular and perivascular eosinophilic infiltrates were present with mild spongiosis. The blocd eosinophil count was 9%. The patient responded well to systemic administration of corticosteroid and dapsoni, (Kor J Dermatol 29(2):237 240)

모누두 종양양 변화를 보인 피지선 모반

백용관,박성주,민형근,이호균,김종민 ( Yong Gwan Baik,Sung Ju Park,Hyung Geun Min,Ho Gyun Lee,Jong Min Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.6

Cribier and Grosshans(1995) reported two cases of tumor of the follicular infundibulum(TFI) arising in nevus sebaceus for the first time. In 1961 Mehregan and Butler described a new benign adnexal neoplasm, which they called t,umor of the follicular infundi4ulurn. Since then few observations have been published. The majority of the lesions are solitary. They appeared in adults, predominantly in wornen, on the face, arm, and neck. Histopathologically, the unique feature is a benign hyperplastic lesion that extends from the follicular infundibuluni. as an epithelial plate either with underlying elastic fiber network in TFI or without underlying elastic fiber network in TFI like change. A 52-year-old man has haf a solitary, well-defined, hairless, verrucous plaque on his right supra auricular area for about 10 years. It has seerned to increase gradually in size over the last year. The histologic findings shwed a plate-like growth of epithelial cells in the upper dermis extending parallel to the epidermis with multiple connections at the lower margin of the epidermis. The peripheral cell layer of ttie tumor plate showed palisading, and centrally located cells were pale staining. Many hair follicl s, mature sebaceous glands, ectopic apocrine glands, and inflammatory cell infiltrations were present in the dermis. However, there was no elastic fiber network beneath the epithelial cell plate. We believe our case is the first to be reported in Korea as TFI-like change in nevus sebaceus. (Korean J Dermatol 1997;35(6): 1208-1211)

화상환자의 역학조사

최준용(June Young Choi),민형근(Hyung Geun Min),김종민(Jong Min Kim),김종현(Jong Hyun Kim),안형숙(Heong Sook Ahn) 대한피부과학회 2001 대한피부과학회지 Vol.39 No.5

N/A Background: A burn injury is not only a life-threatening problem for the injured patient but may have serious physical, psychological and financial effects on the individual, the patients family and society. Despite the high frequency of factors predisposing to burns, preventive measures are few, with a virtual absence of educational campaigns for the population. Thus, the epidemiologic data of patients would be of benefit for the region. Objective: The purposes of this study were to understand burn injuries and to plan effective postburn management. Methods: We reviewed and analyzed the records of 593 cases of burn patients who were admitted to the department of general surgery in Hangang Sacred Heart Hospital from May 1999 to April 2000. Results: Males were more affected than females; 69.1% were males and 30.9% were females. The 31-45 age group had the highest rate of burns (36.5%). The most common burn type was by flame burn injury (59.9%), followed by scalding burn injury (24.0%). In 49.6% of the cases, the extent of the burned surface was under 20%. The number of deaths in this study was 39 patients (6.6% of total burn patients). The most frequent cause of death was sepsis (51.2%), followed by ARDS (20.6%), and burn shock (17.9%). When 51-60% of the surface area was burned, the mortality was 16.7%, when over 61% of the surface area was burned, the mortality was 41.4%. Conclusion: It is evident that the best approach to rectifying the harm caused by burn injury is prevention.

피부의 양성 및 악성 혈관종양에서 CD34표현에 관한 연구

백용관 ( Yong Kwan Baik ),민형근 ( Hyung Geun Min ),이호균 ( Ho Gyun Lee ),김종민 ( Jong Min Kim ),손진희 ( Jin Hee Sohn ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.5

Background: CD34 is a 115 kD glycoprotein which is expressed on hematopoietic progenitor cells. It is also known as an immunohistochemical marker of endothelial cells. Objective : This study was designed to investigate the patterns of CD34 expression on: (1) cutaneous benign and malignant vascular tumors and (2) on the mature and immature vessels of pyogenic grauloma and capillary hemangioma. Method: We performed immunoperoxidase staining using a monoclonal anti-CD34 antibody (QBEND/10) on formalin fixed, paraffin-embedded sections of 23 benign and malignant cutaneous vascular tumors. Results : The results are summerized as follows: 1. In 3 cases of nevus flammeus and 6 cases of carvernous hemangioma, vascular endothelial cells of all hemangiomas showed CD34 expressions. In 5 cases of angiokeratoma, endothelial cells of hemangioma, did not express CD34. 2. In all 5 cases of pyogenic granulomas and one case of capillary hemangioma, endothelial cells of mature vessels, endothelial cells near the well-formed lumina and endothelial cells showing intracellular lumina showed strong positivity for CD34, wbile endothelial cells far from the lumina and endothelial cells without lumina formation mostly showed negative staining for CD34. 3. One cese of Kaposis sarcoma showed focall positivity for CD34 both in endothelial cells of the small, well-formed vessels and spindle cells. Two cases of angiosarcoma showed CD34 expression only in endothelial cells of well-formed, normal appearing vessels, whereas atypical endothelial cells of tumor vessels and spindle cells were negative for CD34. Conclusion : CD34 could be a marker for endothelium in mature, well-differentiated vascular structures and may serve as a marker of lumen formation or differentiation of endothelial cells. (Korean J Dermatol 1998;36(5): 759-764)

성인에 발생된 황색육아종 2예

정찬우(Chan Woo Chung),민형근(Hyung Geun Min),양준모(Joon Mo Yang),이일수(Eil Soo Lee) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

Recently, we have experienced two cases of xanthogranuloma in adults presenting either a solitary papule or multiple papules. Laboratory findings inculding blood lipid substances such as cholesterol and triglyceride were within normal limits. In both cases, we could not find any other extracutaneous manifestations. Granulomatous infiltrates containing foam cells, foreign body giant cells and Touton giant cells as well as histiocytes and lymbhocytes were revealed by histopathologic findings(Korean J Dermatol 1999;37(9) 1325∼1329)

비후성 반흔 / 켈로이드에 대한 냉동 외과술의 효과

박성주 ( Sung Ju Park ),민형근 ( Hyung Geun Min ),이호균 ( Ho Gyun Lee ),김종민 ( Jong Min Kim ),이일성 ( Eil Seong Lee ),강희정 ( Hee Jung Kang ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.5

Background A variety of therapeutic regimens has been used in the treatment of hypertrophic scars/keloids with onsatisfactory final results. Application of cryosurgery could be beneficial sinee it was reported to produce less scarring and recurrence after treatment compared with other methods. Objective This study was undertaken to evaluate the effect of the cryosurgery through objective, quantitative measurement of hypertrophic scar/keloid thickness and to assess the influence of the cryosurgery on fibroblasts. The latter was achieved through fibroblast cultures established from hypertrophic scars/keloids. Methods . Eight patients, ageA 17 to 47 years old, with hypertrophic scars/keloids were treated with liquid nitrogen using the cantact method. One freeze-thaw cycle of 10-30 seconds per lesion was employed, and if needed, treatment was repeated every 20 to 40 days. The thicknesses of the lesions were measured objective,ly with ultrasound in five patients, before and after cryosurgery and were compared with controlled scars in other areas. In three patients, we cultured fibroblasts from the treated and the untreated lesions and exmuned the rate of fibroblast proliferation and collagen production. Results: In all five patients, thicknesses of the hypertrophic scars/keloids decreased compared to those of controlled areas after treatment. Five of 6 hypertrophic scar cell lines demonsbated decreased fibroblast proliferation rates in comparison to control fibroblast lines. Collagen produced by the fibroblasts was variable. Conclusion : Cyosurgery was effective and safe in the treatment of hypertrophic scars/keloids. (Korean J Dermatol 1998,36(5): 765-771)

위성병변이 동반된 소엽성 진피내모반

이일수(Eil Soo Lee),민경식(Kyeong Sik Min),민형근(Hyung Geun Min),김종민(Jong Min Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3

A 37-year-old female presented with a lobulated 2.5 x 1.5cm sized tumor with several sat ellite papules on the left lateral malleolar area for 27 years. Hiopsy specimens from hoth the lobulated lesion and the satellite lesion showed findings similar with features of intradermal nevus. (Kor J Dermatol 1992; 30(3):418-421)