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문봉태(BT Moon),정병헌(BH Jung),안광순(KS Ahn),윤중한(JH Yoon),지용헌(YH Chee),김은중(EJ Kim),김세일(SI Kim),이헌영(HY Lee) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.1
Sarcoma of the uterus is a term applied to heterogeneous group of highly malignant neoplesm of mesodermal origin and is the most lethal of all primary uterine tumors. Fortunately, the lesion is rare and is seldom encoountered by the individual gyne cologist and the personal experience of any one individual with this serous disease is necessarily limited. The various members of this group are uncommon even in a high concentration of malignant uterine tumors, such as seen in a hospital specializing their treatment. The literature on this subject is composed largely of isolated case reports with a brief review of the literature pertinent to particular types of sarcoma-sarcoma botryoides, leiomyosarcoma, labdomyosarcoma and so on. Due to the limited material, however, most of the discussion has focused on leiomyosarcoma, endometrial stromal sarcoma and malignant mixed M llerian tumor. This study was undertaken to correlate the clinical findings, diagnoses, managements, and ultimate outcome of each particular group of uterine sarcoma at the Catholic University Medical Center during the 14 years from 1975 to 1988.
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내인성 성호르몬과 인체 자궁평활근의 β-아드레날린성 수용체와의 관계
이경숙(KS Lee),문봉태(BT Moon),홍경선(KS Hong),노정숙(JS Noh),신진웅(JW Shin),이종건(CK Lee),나종구(JG Na) 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.1
The adrenergic response of the myometrium and concentration of adrenergic receptors in influenced by exogenous gonadal steroids in rabbit uteri. In human studies, it was also observed many years ago that the uterine contractile response to catecholamine stiumlation could be modulated by changes in the gonadal steroid environment. The ability to inhibit uterine contractions by activation of β-adrenergic receptor (myometrial relaxation) has clinical applications for the treatment of preterm labor. In order to prove the hypothesis that endocrine changes at different phases of the reproductive cycle and gestation might alter the β-adrenergic receptor concentration and affinity, we quantitated β-adrenergic receptor concentration and affinity in myometrium from women during the mid-follicular phase, mid-luteal phase, in postmenopausal women and from women at term pregnancy. Using the radiologand idione 125-labeled iodocyanopindolol with high specific activity and high affinity, the β-adrenergic receptor concentrations were determined. The results were as follows; 1. β-adrenergic receptor concentration and dissociation constant (Kd) were 63.4± 22.2fmol/mg protein and 32.4±13.6pmol/L, respectively from women during the mid follicular phase (estradiol:75~75pg/ml, progesterone:<1ng/ml) of the cycle which corresponded to pure but mild estrogen stimulation. 2. β-adrenergic receptor concentration and dissociation constant (Kd) were 40.8± 12.7fmol/mg protein and 30.8±11.7pmol/L, respectively from women during the midluteal phase (estradiol; 100~300pg/ml, progesterone; 5~20ng/ml) of the cycle which correspond to increased estrogen stimulation, combined with progestestational stimulation. 3. β-adrenergic receptor concentration and dissociation constant (Kd) were 52.8± 11.0 fmol/mg protein and 28.1±8.1pmol/L, respectively from women in postmenopaual phase (estradiol;10~20pg/ml, progesterone; <0.1ng/ml) which are characterized by low circulating levels of gonadal steroid homones. 4. β-adrenergic receptor concentration and dissociation constand (Kd) were32.5± 10.3 fmol/mg protein and 36.9±15.7pmol/L, respectively from women with term pregnancy (estradiol; 10~45ng/ml, progesterone; 75~250ng/ml) which are characterized by very high levels of both estrogen and progesterone. 5. The concentration of β-adrenergic receptor during the mid-follicular phase were significantly increased compared with those during the mid-luteal phase and at term pregnancy. 6. The concentration of β-adrenergic receptor at term pregnancy were significantly decreased compared with those from the non-pregnancy myometrium. But there was no significant difference in dissociation constant (Kd) among the mid-follicular phase, mid-luteal phase, postmenopausal and term pregnancy. The findings suggest that the β-adrenergic receptors in the myometrium might be modulated by endogenous gonadal steroid hormones. But the alteration of myometrial contractility during menstrual cycle and pregnancy may not be directly mediated by β-adrenergic system.
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자궁경부암 항암제치료 환자에서의 Bleomycin Induced Pulmonary Toxicity 4 례
신진웅(JW Shin),문봉태(BT Moon),홍경선(KS Hong),이경숙(KS Lee),정난주(NJ Jeong),김세일(SI Kim),남궁성은(SE Namkoong),김승조(SJ Kim) 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.2
Bleomycin has been widely used as chemotherapeutic agent for the treatment of uterine cervical cancer, Hodgkin`s disease, Malignant lymphoma and squamous cell cancer of skin, esophagus and Lung. Although Bleomycin has side effects of headache, nausea, vomiting and high fever and toxicities of skin pigmentation, hyperkeratosis and skin ulceration but most of all, interstitial pulmonary fibrosis is the most serious complication. From October, 1984 to August, 1990 in the Department of Obstetrics and Gynecology, Catholic University Medical College, we experienced 4 cases of death from Bleomycin induced pulmonary fibrosis during the courses of combination chemotherapy of VBP in patients with cervical cancer. Mean age was 51.8 and clinical stages were Ⅱ1, Ib, Ⅱa and Ⅲ (as FIGO classification). In case 1 the patient received radiation therapy concurrently with chemotherapy. In case 2 the patient received chemotherapy before and after radical hysterectomy. In case 3 the patient received chemotherapy after modified radical hysterectomy and radiation therapy. In case 4 the patient received chemotherapy after radiation therapy. Mean amount of administered Blecomycin was 343.8mg and mean duration from initial use of Bleomycin to the symptom apperance of pulmonary fibrosis was 7 and half months. Mean durations from appearance of symptom of pulmonary fibrosis to death was 3 weeks.
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