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김종국,정은주,이은진,신희종,이원근,Kim, Chong-Kook,Jeong, Eun-Ju,Lee, Eun-Jin,Shin, Hee-Jong,Lee, Won-Keun 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.1
The bioequivalence of two omeprazole enteric-coated products was evaluated in 16 normal male volunteers (age 26-32 yr, body weight 57-75 kg) following single oral administration. Test product was enteric-coated KD-182 tablet (Chong Kun Dang Corp., Korea) and reference product was $Rosec^{\circledR}$ capsule containing enteric-coated pellets of omeprazole (Yuhan Corp., Korea). Both products contain 20 mg of omeprazole. One tablet or capsule of the test or the reference product was administered to the volunteers, respectively, by randomized two period cross-over study ($2\;{\times}\;2$ Latin square method). Average drug concetrations at each sampling time and pharmacokinetic parameters calculated were not significantly different between two products(p>0.05); the area under the concentrationtime curve to last sampling time (8 hr) $(AUC_{0-8hr})$ $(1946.5{\pm}675.3\;vs\;2018.3{\pm}761.6\;ng{\cdot}hr/ml)$, AUC from time zero to infinite $(AUC_{o-\infty})$ $(2288.6{\pm}1212.8\;vs\;2264.9{\pm}1001.3\;ng{\cdot}hr/ml)$, maximum plasma concentration $(C_{max})$ $(772.5{\pm}283.3\;vs\;925.8{\pm}187.7\;ng/ml)$, time to maximum plasma concentration $(T_{max})$ $(2.38{\pm}1.06\;vs\;2.34{\pm}1.09\;hr)$, apparent elimination rate constant $(k_{\ell})$ $(0.5339{\pm}0.2687\;vs\;0.5769 {\pm}0.2184\;hr^{-I})$, apparent absorption rate constant $(k_a)$ $(1.1536{\pm}0.5278\;vs\;0.9739{\pm}0.9507 hr^{-1})$ and mean residence time (MRT) $(3.13{\pm}0.73\;vs \;3.41{\pm}1.04\;hr)$. The differences of mean $(AUC_{0-8hr})$, $C_{max}$, $T_{max}$ and MRT between the two products (3.69, 19.83, 1.32 and 8.99%, respectively) were less than 20%. The power $(1-{\beta})$ and treatment difference $(\triangle)$ for $AUC_{o-8hr}$ $C_{max}$ and MRT were more than 0.8 and less than 0.2, respectively. Although the power for $T_{max}$ was under 0.8, $T_{max}$ of the two products was not significantly different each other(p>0.05). These results suggest that the bioavailability of KD-182 tablet is not significantly different from that of $Rosec^{\circledR}$ capsule. Therefore, two products are bioequivalent based on the current results.
Mixture Regression Model을 이용한 재래시장의 세분집단별 고객충성도에 미치는 영향 변수 분석
김종국(Jong Kook Kim),박윤재(Youn Jae Park),박주영(Ju-Young Park),최자영(JaYoung Choi) 한국유통학회 2007 流通硏究 Vol.12 No.4
본 연구는 우리나라 유통산업환경의 경쟁이 날로 심화되고 있는 가운데 그간 대표적인 소매유통공간이면서도 1996년 유통시장개방 이후 급속하게 경쟁력이 약화되고 매출이 감소하고 있는 재래시장을 대상으로 세분화된 고객집단별로 재래시장에 대한 고객충성도에 미치는 영향을 파악하여 차별화된 마케팅 전략을 제공하는데 그 목적이 있다. 본 연구에서는 재래시장의 특성, 소비자 속성 등을 파악하고 특성에 따라 세분시장별로 고객의 충성도를 결정하는 요인들을 파악하기 위해 결합회귀모델(Mixture Regression Model) 방법을 이용하였다. 이 분석 모델은 재래시장 속성에 대한 가치를 예측변수로, 소득은 공변량으로, 종속변수는 고객 충성도로 설정하였다. 연구결과, 재래시장 이용 고객은 4개의 집단, 즉 ‘접근편리성중시’(33.7%), ‘가격중시’(29.7%), ‘쇼핑환경중시’(22.0%), ‘머천다이징중시’(14.5%)로 구분할 수 있다. 또한 재래시장 고객 충성도에 미치는 예측 변수는 소비자가 우선 시하는 가치 및 소득의 크기에 따라 세분화 된 시장별로 차이가 있음을 보여주고 있다. 학문적인 면에서 본 연구는 결합회귀모델 분석을 적용함으로써 기존의 방법론으로는 분석에 어려움이 있었던 세분 집단의 수의 결정, 모수 추정 등에 대해 보다 객관적인 자료를 제공함으로써 고객 충성도에 대한 보다 정확한 예측에 기여할 것으로 기대 한다. The purpose of this study is to provide the strategic implication of the Korean open air market by examining the factors affecting customer loyalty for various market segments as their competitive environment becomes more turbulent. We have undertaken empirical research that uses the methodology of a mixture regression modeling, as a way to ascertain the determinants of customer loyalty toward the Korean open air market, which should form the base of strategy for each segment. We construct a mixture regression model which uses perceived the Korean open air market value dimensions as explanatory variables, an income as a covariate variable, and a customer loyalty as a dependent variable. The analysis of results show that customers are statistically divided into four segments: 'Accessibility'(33.7%), 'Price'(29.7%), 'Shopping environment,'(22.0%), and 'Merchandising,'(14.5%) groups. The findings also showed that parameter estimates are different for each group, which indicates that the sensitivity to changes in the Korean traditional market perceived value and the income variable affecting customer loyalty vary among segments.
플라스틱보드드레인(PBD)재의 품질평가 기법에 대한 고찰
김종국(Jong-Kook Kim),윤원섭(Won-Sub Yoon),채영수(Young-Su Chae),유성진(Seong-Jin Yu),김용철(Yong-Cheol Kim) 한국토목섬유학회 2007 한국토목섬유학회 학술발표회 Vol.2007 No.4
This paper present that Investigated about PBD evaluation of quality controls on the basis of PBD quality standard that is applied to vertical drain. Main method of test is tensile strength, Apparent Opening Size and drain capacity test. It seems reasonable that to evaluate calculating analysis result of tensile strength MD and CD average tensility. According to analysis results of Apparent Opening Size, Dry testing method is bigger than Wet testing method. It thought must decide on quality standard through considering field soil particle. Drain capacity test have different standard according to method of test. Therefore, it seems to necessary transform considered that standard method of test, test condition, specification need.
김종국 ( Jong Kook Kim ),송인선 ( In Sun Song ),신혜란 ( Hye Lan Shin ),진광선 ( Kwang Seon Jin ),윤일지 ( Il Ji Yoon ),최승훈 ( Seung Hoon Choi ),오민석 ( Min Suck Oh ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.1
Objective: The aim of this study was to investigate the effects of absolute bed resting(ABR) period on bone mineral density(BMD) recovery in acute stroke patients. It is necessary for acute stroke patients to spend a few days-absolute bed resting period-for treatment. During ABR period, bone mineral density have a tendency to decrease. But During exercise period, BMD have a tendency to increase. Therefore this clinical study investigate the change of BMD in acute stroke patients. Methods: This clinical study have been carried out with 50 cases of acute stroke patients that entered Cheongju Oriental Hospital from March to October 2003 and investigates through several items-diagnosis, sex, age, ABR period, smoking, drinking, hypertension, diabetes mellitus(DM) and osteoporosis. Results & Conclusions: The results were as follows; 1. In change of BMD, 31cases(62%) increased and 19cases(38%) decreased. In 43`s infarction patients 26 cases(60%) increased and. in 7`s hemorrhage patients 5 cases(71%) increased. But significant increase was not. 2. In sexual change of BMD, BMD of female patients increased(p<0.05) significantly. 3. In ABR periodic change of BMD, BMD significantly decreased(p<0.01) according as ABR period were long. 4. In change of BMD according to smoking and drinking, BMD of non-smoking group increased(p<0.05) significantly. 5. In change of BMD according to hypertension, DM and osteoporosis, BMD of non-hypertension group increased(p<0.05) significantly. These results indicate that female, non-smoking group, non-hypertension and group that spent short ABR period BMD increased significantly.