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김제훈 대한약학회 1964 약학회지 Vol.8 No.2
A new alkaloid, named tenuidine was isolated from Polygala tenuifolia Willdenow. Its molecular formula corresponded to $C_{21}$ $H_{31}$ $O_{5}$ $N_{3}$ and its constants were m.p.256, [.alpha.]$_{D}$$^{18.5}$=1200.deg.(ethanol). Its infrared absorption spectra exhibited bands at 3.300, 1600, 1580, 1500 $cm^{-1}$ / confirming indole ring and at 2800-2700 $cm^{-1}$ / indicating quinoline ring. Bands at 1610, 1530 $cm^{-1}$ / indicated the presences of benzene ring and 1642$cm^{-1}$ / carbochelate.e.e.
원발성 위장관 림프종의 수술 후 복합 화학요법과 화학요법 단독과의 비교: 단일 기관 연구
김제훈,이호섭,이준섭,이진영,김수영,김철수,양정욱,유가인 고신대학교(의대) 고신대학교 의과대학 학술지 2015 고신대학교 의과대학 학술지 Vol.30 No.1
Objectives: There is still no consensus on the optimal treatment for primary gastrointestinal lymphoma (PGIL). The aim of this study was to compare surgery combined with chemotherapy and chemotherapy alone in PGIL. Methods: We retrospectively reviewed and analyzed the treatment outcomes of 107 patients with primary gastrointestinal lymphoma diagnosed between March 1999 and December 2009 at Kosin University Gospel Hospital. Patients were divided into two groups: 35 patients who underwent surgery combined with chemotherapy (group A) and 72 patients who were treated with chemotherapy alone (group B). And we analyzed prognostic factors associated with short survival. Results: The 5-year progression free survival rates (PFS) of group A and B were 86.7% and 66.1%, respectively (P = 0.037), while the 5-year overall survival rates (OS) were 86.8% and 68.4%, respectively (P = 0.129). In multivariate analysis, Both PFS and OS were not changed by treatment strategies (surgery combined with chemotherapy or chemotherapy only). The international prognostic index (IPI) was the only independent predictive factor for PFS. Conclusions: In our study, surgery combined with chemotherapy and chemotherapy only make no difference of survival rate. And further randomized prospective studies are needed to confirm a treatment strategies at improving survival outcomes in PGIL patients.
기관지폐암으로 오인된 면역 정상 환자의폐 효모균증 1예
김제훈,이진영,옥철호,정만홍,장태원 대한의진균학회 2016 대한의진균학회지 Vol.21 No.3
We experienced a 59-year-old immunocompetent female patient who complained progressive cough. A bronchoscopic examination revealed an endobronchial mass protruding from the left lower lobe and occluding anterior-basal segment bronchus. Bronchial biopsy and endobronchial ultrasound guided transbronchial needle aspiration were consistent with cryptococcal infection. However, the response of medical therapy was an unsuccessful. Finally, the patient underwent left lower lobectomy with lymph node dissection. We report a case of pulmonary cryptococcosis mimicking bronchogenic lung cancer, and surgical therapy with antifungal treatment resulted in successful resolution of the pneumonia.
Tracheal pleomorphic adenoma with coexisting pulmonary tuberculoma
김제훈,옥철호,장태원,정만홍 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.1
Tracheal tumors are rare and difficult to diagnose. Moreover, delays in diagnosis are very common because the symptoms are nonspecific. As a result, tracheal tumors are commonly mistreated as chronic obstructive pulmonary disease or bronchial asthma. We report a case of a 49-year-old male who presented with a 3- month history of dyspnea and cough. Chest computed tomography scan showed a 1.5×1.3 cm homogenous tumor originating from the right lateral wall of the tracheobronchial angle into the tracheal lumen as well as a 0.5×0.4 cm round nodular lesion at the right upper lobe with multiple mediastinal lymph nodes enlargement. Bronchoscopic findings revealed a broad-based, polypoid lesion nearly obstructing the airway of the right main bronchus. The patient was diagnosed with pleomorphic adenoma which is the most common benign tumor of the salivary glands, but rarely appears in the trachea. Upon surgery, tracheal pleomorphic adenoma and co-existing active pulmonary tuberculoma that had been mistreated as bronchial asthma over 3 months was revealed. Following surgery, the patient underwent anti-tuberculosis treatment. No recurrence has been detected in the 3 years since treatment and the patient is now asymptomatic.
희첨의 신 diterpene glycoside의 화학구조에 관하여
김제훈 대한약학회 1972 약학회지 Vol.16 No.2
A new diterpene glycoside, $C_{26}H_{44}O_{8}{\cdot}H_{2}O, $ m.p. <$225-6^{\circ}, [{\alpha}]_D^{20}=-48^{\circ}$ (0.1% in EtOH) was isolated from methylalcohol extract of Siegesbeckia pubescens $M_{AKINO}$ which has been used as a folk remedy for hypertensive in Korea and its chemical structure was established as (III).
지대주 혹은 지대주 나사 파절이 발생한 임플란트 보철물에서 효과적인 수리 방법
김제훈,유진주,김만용,윤준호,Kim, Jae Hoon,Yoo, Jin Joo,Kim, Man Yong,Yoon, Joon-Ho 대한치과보철학회 2019 대한치과보철학회지 Vol.57 No.1
치과 임플란트는 상실된 치아의 수복에 효과적이고 예측 가능한 치료 방법이다. 하지만 임플란트 사용이 증가함에 따라 합병증도 증가하고 있다. 이 중 기계적 합병증은 발생 빈도가 높을 뿐 아니라 임플란트의 수명이 길어질수록 더 많이 발생하므로 이에 대한 대책이 필요하다. 이에 임플란트의 가장 흔한 기계적 합병증인 지대주 파절과 지대주 나사 파절의 증례에서 파손된 부위만 재제작하여 파손되지 않은 구성요소를 최대한 보존할 수 있는 방법을 소개하고자 한다. Dental implants are an effective and predictable treatment for restoration of missing teeth. However, as the use of implants increases, complications are also increasing. The mechanical complications are not only highly frequent, but also increasing as life span of an implant increases, thus, solutions should be prepared. In this report, we will present a case dealing with abutment fracture and abutment screw fracture which are the most common mechanical complication of the implant, focusing on preserving and reusing existing components by reconstructing only the damaged parts.
김제훈 한국생약학회 1982 생약학회지 Vol.13 No.4
회첨(Siegesbeckia pubescens Makino)은 漢方에서 單味로 血壓 및 半身不隨 등에 用藥되어 왔다. 이 生藥의 作用物質을 究明하기 위하여 成分 硏究를 着手하여 Campound A: C<sub>20</sub>H<sub>32</sub>O₃, mp 192∼3˚, B: C<sub>20</sub>H<sub>32</sub>O₄, mp 260∼2˚, C: C<sub>26</sub>H<sub>44</sub> O₃·H₂O, mp 225∼6˚, D: C<sub>20</sub>H<sub>32</sub>O₃, mp 207.5˚, E: C<sub>20</sub>H<sub>32</sub>O₄, mp 239∼42˚, F: C<sub>20</sub>H_(30)O₄, mp 258∼60˚ 및 steroids로서 campesterol, stigmasterol, β-sitosterol, α-spinasterol, stigmast-7-enol 등의 成分을 究明하였고 이들 物質의 生理作用에 對하여 檢討하였다.