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항정신병약물을 투여 받은 정신분열병환자의 체중,BMI,및 혈장 Leptin 농도의 변화
김재종,변기욱,김봉조,손진욱,박철수 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1
Objective : Weight gain is a major side elect of treatment with newer antipsychotics. The mechanism, however, of weight gain is poorly understood. Recent researches suggested that there is a positive relationship between the levels of plasma leptin and the weight gains of the schizophrenic patients receiving the antipsychotics. This study was conducted to verify, firstly, the effect of the use of olanzapine and haloperidol on the weight gain, BMI, and the change of plasma leptin concentration and to find, secondly, whether there is any co-relationship between the plasma leptin level and the antipsychotic-induced weight gain. Method : 18 male schizophrenia inpatients were divided into two groups receiving olanzapine(N=8) or haloperidol(N=10) treatment and weight, BMI and plasma leptin level were measured weely over 5 weeks. Prior to the whole measurements, and patients were curtailed all diet from 21:00 of the previous day and the blood samples were collected at 8:00 and 8:15 in the morning. Results : In schizophrenic patients receiving olanzapine, significant increases in weight and BMI were found from the second week of medication, while those of the plasma leptin levels were shown from third week. In schizophrenic patients receiving haloperidol, no significant increases in the measurements were found for the 5 weeks of medication period. There was a close co-relationship between the plasma leptin concentration and the body weight increases. The weight gains were initiated from the second week of medication while the increases of plasma leptin concentration were started from the third week. The weight gains were followed by the continuative increases in plasma leptin levels for up to 5 weeks. Conclusion : Medication of olanzapine appears to be associated with an increase in weight, BMI, and plasma leptin level, whereas that of haloperidol does not. From the results observed the following suggestion could be made that most probable reason for olanzapine-induced increases in leptin levels are weight gain.
6-치환된 1,3,5-trianzine-2,4-dithiol 유도체의 반응성 연구
김재종,이용희,성대동 동아대학교 기초과학연구소 2001 基礎科學硏究論文集 Vol.18 No.1
Several 6-substituted-1,3,5- triazine-2,4-dithiol derivatives were prepared and their infrared were recorded on KBr disk. All these compounds show distinctly separate absortion bands for C-S and C-N streching. Each of these bands is split into a doublet. This is explained in terms of the existence of rotational isomers.
Peroxidase mRNA 의 In vitro Translation 및 특성에 관한 연구
김재종,김승수 ( Jae Jong Kim,Soung Soo Kim ) 생화학분자생물학회 1987 BMB Reports Vol.20 No.3
Total celluar RNA was isolated from tobacco callus (Nicotiana tabacum L., var Virginia 115) with guanidium thiocynate and guanidine HCl method. The total RNA was further fractionated by oligo (dT)-cellulose chromatography. For translation of peroxidase mRNAs in cell-free protein-synthesizing system, rabbit reticulocyte lysate was tested and the optimum translational conditions of peroxidase mRNAs were established. The lysate containing 2 mM Mg^(2+), 80 mM K^+ and 15 μM hemine was found to be the optimum condition for the translation of one population of peroxidase mRNAs. On the other hand, 1 mM Mg^(2+) was the optimum for the other population of peroxidase mRNAs. The incorporation of [^(35)S]-Met into peroxidase was increased up to 1 ㎍ of poly(A)^+ RNA and then it was decreased. Size fractionation of total cellular RNA was carried out by 6M urea agarose electrophoresis. Peroxidase mRNAs were distributed at slightly above 16S and 23S regions. As a result of immunoprecipitation of in vitro translation products with anti isoperoxidase C₃ and A₄ antiserum, we found C₃, C₁ or/and C₂, C₄ crossreactive to anti C₃ antiserum and A₄, A₁ to anti A₄ antiserum.
In Vitro Translation and Characterization of Peroxidase mRNAs from Tobacco Callus
김재종,김승수,Kim, Jae-Jong,Kim, Soung-Soo 생화학분자생물학회 1987 한국생화학회지 Vol.20 No.3
담배 callus (Nicotiana tabacum L., var Virginia 115)로 부터 guanidium thiocyanate 및 guanidine HCl 방법을 이용 total cellular RNA를 분리 하였으며 oligo (dT)-cellulose 친화성 크로마토그라피 방법에 의해 $poly(A)^+$ RNA를 분리하였다. Protein-synthesizing cell-free system을 이용한 peroxidase mRNA의 translation을 위 해 rabbit reticulocyte lysate의 peroxidase mRNA에 대한 최적 translation 조건을 조사한 결과 2mM $Mg^{2+}$, 80 mM $K^+$, $15\;{\mu}M$ hemine 및 $1\;{\mu}g$의 $poly(A)^+$ RNA 일때 최대의 방사능 유입과 peroxidase 활성을 나타냈다. 그러나 어떤 peroxidase population에 있어서는 1 mM $Mg^{2+}$을 최적 조건으로 갖는 경우도 있었다. 6M urea agarose electrophoresis에 의해 total cellular RNA를 분석해 본 결과 16S 및 23S 부근에서 peroxidase mRNA를 확인할 수 있었다. 또한 Anti isoperoxidase $C_3$ 및 $A_4$antiserum을 이용한 immunoprecipitation에 의해 in vitro translation products 내에서 anti $C_3$와 crossreactivity를 갖는 isoperoxidase $C_3$, $C_4$, $C_1/C_2$ 및 anti $A_4$와 crossreactivity를 갖는 isoperoxidase $A_4$, $A_1$을 확인할 수 있었다. Total celluar RNA was isolated from tobacco callus (Nicotiana tabacum L., var Virginia 115) with guanidium thiocynate and guanidine HCl method. The total RNA was further fractionated by oligo (dT)-cellulose chromatography. For translation of peroxidase mRNAs in cell-free protein-synthesizing system, rabbit reticulocyte lysate was tested and the optimum translational conditions of peroxidase mRNAs were established. The lysate containing 2 mM $Mg^{2+}$, 80 mM $ K^+$ and $15\;{\mu}M$ hemine was found to be the optimum condition for the translation of one population of peroxidase mRNAs. On the other hand, 1 mM $Mg^{2+}$ was the optimum for the other population of peroxidase mRNAs. The incorporation of [$^{35}S$]-Met into peroxidase was increased up to $1\;{\mu}g$ of $poly(A)^+$ RNA and then it was decreased. Size fractionation of total cellular RNA was carried out by 6M urea agarose electrophoresis. Peroxidase mRNAs were distributed at slightly above 16S and 23S regions. As a result of immunoprecipitation of in vitro translation products with anti isoperoxidase $C_3$ and $A_4$ antiserum, we found $C_3$, $C_1$ or/and $C_2$, $C_4$ crossreactive to anti $C_3$ antiserum and $A_4$, $A_1$ to anti $A_4$antiserum.
공공택지 내 점포주택 거주자 만족도 및 중요도 분석: 위례신도시 및 청라국제도시를 중심으로
김재종,조미정 (사) 한국도시재생학회 2019 도시재생 Vol.5 No.2
In order to analyze the importance and satisfaction in a store house, previous studies and relevant literatures are studied. The result of this study was obtained through T-test and IPA analysis of the results of the survey conducted by the residents of two newly built residential district which have different population density plan, one is Wirye new city (less than 5 households per dwelling unit) and the other is Cheongna International City (less than 3 households per a dwelling unit). As a result of the study, the necessity of stores was answered as the lowest importance and satisfaction in both districts. The frequency of shop visiting was very low, as shown in the survey where 50% of the respondents were reported to barely visit the shops, less than 4 times a month. Also, category of retail, satisfaction of green spaces such like parks, and appropriateness of rent fee of shops have to be improved. This study may help to solve oversupply problem to develop high quality residential and commercial environment for the shop house in the future.