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김우주,이재규 한국전문가시스템학회 1994 학술대회 Vol.2 No.1
When we apply optimization model to most planning problems, additional information tends to be accumulated since the initial model building and its partial implementation. Particularly, if such information means restrictions to the values on a set of the designated decision variables, it may cause the infeasibility or severe degradation of optimal solution in the optimization model. The only way to overcome this is the coefficients should be adjusted so that the desired values on the infeasible decision variables can be obtained. Let us call such an effort an adaptive optimal control on the optimization model. Since there is no known analytical method to perform such adaptive optimal control on the optimization model, we proposed a neural network approach for the adaptive optimal control and validated with the scheduling problems in a refinery plant. To help the adaptive optimal control procedure, we develop a tool UNIK-OPT/NN which integrates the neural network model with the semantically represented linear, programming model that are generated by the knowledge-assisted optimization modeler UNIK-OPT. UNIK-OPT/NN is also applied to the refinery case and it is shown that the user can quickly and easily develop an adaptive optimal control model by using UNIK-OPT/NN.
정상혈압을 가진 폐색전증 환자에서 우심실 기능부전의 진단을 위한 B-typenatriuretic peptide와 Troponin I의 유용성 비교
김우주,윤재철,오범진,김원,임경수 대한응급의학회 2008 大韓應急醫學會誌 Vol.19 No.1
Purpose: The severity of pulmonary embolism (PE) is determined by its associated degree of right ventricular dysfunction (RVD). In normotensive PE, the presence of RVD makes the prognosis worse and generally leads to consideration of fibrinolysis treatment. Routine usage of echocardiograhy in the diagnosis of RVD associated with PE is limited in the emergency department (ED). We evaluated the usefulness of B-type natriuretic peptide (BNP) and troponin I (TnI) levels for the diagnosis of right ventricular dysfunction in patients with normotensive PE and we suggest a cutoff value. Methods: Forty-five patients who visited the ED of Asan Medical Center from January 2003 to December 2006 and were confirmed with PE were retrospectively recruited. We excluded patients with heart failure or chronic renal failure. The cut-off values of BNP and TnI for diagnosis of RVD in normotensive PE were determined by receiver operating characteristic curve (ROC) analysis. Results: The cut-off value of BNP and TnI for the diagnosis of RVD were 149 pg/ml and 0.2 ng/ml, respectively, and the area under the ROC curve were 0.87(95% CI, 0.70-0.96) and 0.85(0.68~0.95). There were no significant differences in diagnostic accuracy between BNP and TnI (p=0.841). Conclusion: In patients with normotensive PE, BNP and TnI were useful diagnostic test of RVD. The significant difference in diagnostic accuracy between BNP and TnI was not found. When BNP or TnI is elevated in normotensive PE patients, physician should consider RVD and suggest further evaluations.