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염증성 장질환 진료에 있어서 소아청소년에서 성인으로의 성공적인 전환은 어떻게 할 수 있는가?
김미진 ( Mi Jin Kim ),홍성노 ( Sung Noh Hong ),김영호 ( Young-ho Kim ),최연호 ( Yon Ho Choe ) 대한소화기학회 2021 대한소화기학회지 Vol.77 No.5
With the increasing incidence of pediatric inflammatory bowel disease (IBD) in children and its impact throughout life, transition care has become an important issue. In Korea, no guidelines have been proposed to support the transition from the pediatric clinic to the adult IBD clinic. This paper reviews the current issues related to IBD patient care during the transition from pediatrics to adults to identify the barriers and critical elements for a successful transition. Thus far, a multi-disciplinary pediatric/adult clinic or alternate visits between pediatric and adult health care providers is the best model for pediatric to adult IBD clinics. Self-reliance and independence of patients with pediatric IBD are also essential for a successful transition. In addition, the timing of the transition from a pediatric clinic to an adult IBD clinic should not be determined because the issue is not the chronological age but rather the individual maturity. (Korean J Gastroenterol 2021;77:227-230)
김흥업 ( Kim Heung Eob ),김영호 ( Kim Yeong Ho ),최원혁 ( Choe Won Hyeog ),김정환 ( Kim Jeong Hwan ),육청미 ( Yug Cheong Mi ),이재욱 ( Lee Jae Ug ),심상군 ( Sim Sang Gun ),손희정 ( Son Hui Jeong ),이풍렬 ( Lee Pung Lyeol ),김재준 대한소화기학회 2003 대한소화기학회지 Vol.42 No.5
In western countries, symptomatic diverticulitis develops in about 20% of the population with colonic diverticula, and it is mainly located at the left-sided colon. The clinical characteristics of diverticulitis have rarely been investigated although its incidence is increasing in Asia including Korea. The aim of this study was to compare diverticulitis with asymptomatic diverticulosis and to compare the clinical characteristics of right-sided diverticulitis with those of left-sided diverticulitis. Methods: We retrospectively investigated the medical records of the patients who had symptoms and signs of diverticulitis. Their diagnosis was confirmed with computed tomography, barium study, colonoscopy and/or operations at Samsung Medical Center from September 1998 to February 2002. The control cases of asymptomatic and incidental diverticulosis were randomly selected during routine health check-up after matching age and sex. Results: Twenty-seven patients with diverticulitis (male:female=14:13) were included. The mean age was 53 (27~86). The ratio of right and left diverticulitis was 20:7, which was similar to the ratio of diverticulosis. The complications, especially perforation, were more frequent in the patients with left-sided diverticulitis (p<0.05). Conclusions: Colonic diverticulitis is more prevalent at the right colon and left colonic diverticulitis has more complications than right colonic diverticulitis in Korea. (Korean J Gastroenterol 2003;42:363-368)
이상민,김영호,오미경,홍석인,고항주,이치우,Lee, Sang-Min,Kim, Young-Ho,Oh, Mi-Kyung,Hong, Suk-In,Ko, Hang-Ju,Lee, Chi-Woo 한국전기화학회 2010 한국전기화학회지 Vol.13 No.2
Cu(In, Ga)$Se_2$ (CIGS) 박막은 다원화합물이기 때문에 제조공정이 매우 까다롭다. 진공장치를 사용하는 제조 방법으로 동시증착법, 스퍼터링법 +셀렌화가 있고, 비진공 제조 방법으로 전기화학적인 전착법이 있다. 각 방법에 있어서도 출발 물질의 종류에 따라 다양한 제조 방법이 동원 될 수 있다. 진공증착에 의한 방법은 고품질의 박막을 얻는데 사용 되고 있으나 고가의 진공장비가 사용되므로 대면적화에 따른 제조비용 측면에서 문제가 있다. 이에 비하여, 전착법은 간단하면서도 저가로 대면적화를 이룰 수 있다는 장점 때문에, 많은 관심이 기울여지고 있다. 본 연구에서는 Mo/Glass전극위에 Ga/(In + Ga) = 0.3의 성분비를 만족시키는 CIGS 박막을 전기화학적으로 제조하기 위하여, $Cu^{2+}$, $In^{3+}$, $Ga^{3+}$, $Se^{4+}$ 4성분을 모두 포함하는 전해질 수용액 내에서, 4성분의 이온들이 동시에 환원되는 전위를 조절하여 CIGS 박막을 전착 하였다. SEM을 이용하여 얻어진 CIGS 박막의 전착된 시료의 표면을 관찰하였고, EDS로 그 조성을 분석하였다. 또한, XRD를 이용하여 전착시료의 열처리 전후의 결정성변화를 조사하였다. The chalcopyrite $Cu(In_xGa_{(1-x)})Se_2$ (CIGS) is considered to be one of the effective light-absorbing materials for thin film photovoltaic solar cells. We describe the electrodeposition of CIGS thin films in ambient laboratory conditions, and suggest the electrochemical conditions to prepare stoichiometric CIGS thin films of Ga/(In + Ga) = 0.3. In acidic solutions containing $Cu^{2+}$, $In^{3+}$, $Ga^{3+}$ and $Se^{4+}$ ions, the CIGS films of different Cu/In/Ga/Se chemical compositions were electrodeposited onto Mo/Glass substrate. The structure, morphology and chemical composition of electrodeposited CIGS films were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), and Energy dispersive X-ray spectroscopy (EDS), respectively.
항균성 미강 단백질 필름 개발을 위한 Bacteriocin 생성균주의 선별 및 특성
김은정,김경미,한혜경,김영호,권기성,배동호,Kim, Eun-Joung,Kim, Kyung-Mi,Han, Hye-Kyung,Kim, Young-Ho,Kwon, Ki-Sung,Bae, Dong-Ho 한국응용생명화학회 2003 한국농화학회지 Vol.46 No.4
경제성과 항균력을 갖춘 미강단백질 필름을 개발하기위한 연구의 일환으로 미강배지에서 bacteriocin을 생성할 수 있는 균주를 선별하고 그 특성을 조사하였다. 그 결과, Pseudomonas aeruginosa 9027에 대한 항균효과를 지닌 Pseudomonas putida 21025를 선별하였으며, 이 균이 생성한 bacteriocin은 쌀에 존재하는 미생물 및 토양미생물에 대하여 넓은 항균활성을 갖는 것으로 나타났다. 지금까지 이용되고 있는 미강단백질 추출 조건에 대한 적합성을 알아보기 위해 bacteriocin의 특성을 조사하였다. Pseudomonas putidia 21025에서 생성되는 bacteriocin은 $50^{\circ}C$이상에서는 한 시간 후 활성이 저하되었으며, 헥산과 에탄올을 제외한 메탄올, 톨루엔, 클로로포름, 아세톤, 메틸 를로로포름등의 유기용매에서 활성이 현저하게 저하되었다. 그러나, 이 bacteriocin은 pH 6.0-9.0에서 2시간동안 안정하였고, $50^{\circ}C$이하에서 안정하였으며, 에탄올에 대하여 3시간동안 안정한 특성을 가지고 있는 것으로 나타났다. 또한 부분정제한 bacteriocin의 분자량은 약 21.6 kDa로 비교적 작은 분자량을 나타내었다. This study was conducted to select the bacteriocin-producing microoreanism cultivated in the rice bran culture and to characterize the produced bacteriocin for the further purpose of economical and anti-bacterial rice bran protein film. Pseudomonas putida 21025 was cultivated from rice bran and identified as a producer of a bacteriocin which showed bactericidal activity against Pseudomonas aeruginosa 9027. Bacteriocin produced by Pseudomonas putida 21025 showed a broad spectrum of activity against spoilage and soil bacteria. The activity of the bacteriocin produced by Pseudomonas putida 21025 decreased after 1 hr of staying at the temperature of $50^{\circ}C$, and with the presence of some organic solvents, except hexane and ethanol. However, the bacteriocin activity was stable throughout the pH ranges of 6-9 for 2 hrs, at the temperature lower than $50^{\circ}C$, and with the presence of ethanol for 3 hrs. The bacteriocin was partially purified by 50% ammonium sulfate precipitation followed by subsequent dialysis. Direct detection of the partially purified bacteriocin on SDS-PAGE suggested that it had an apparent molecular mass of about 21.6 kDa.
성향정기산(星香正氣散)이 뇌허혈(腦虛血)을 유발(誘發)시킨 백서(白鼠)의 신경전달물질(神經傳達物質)에 미치는 영향(影響)
예경욱,박치상,이은주,송지혜,김미려,조정숙,김영호,박창국,양재하,Yea, Gyeong-Uk,Park, Chi-Sang,Lee, Eun-Ju,Song, Jee-Hea,Kim, Mi-Ryeo,Cho, Jung-Sook,Kim, Young-Ho,Park, Chang-Gook,Yang, Chae-Ha 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1
Objectives : The aim of this study is to investigate that Sunghyangjeongki-San which has been frequently medicated in the early stage of stroke can protect against ischemic damage in rat brain Methods : Extracellular levels of amino acids(glutamate, aspartate, GABA, glycine, taurine, tyrosine, alanine), organic acids(pyruvate, lactate), and cerebral infarction volume were measured at the striatum of rats subjected to permanant focal cerebral ischemia induced by 2 hours of middle cerebral artery occiusion(MCAO). Rats were orally administered with Sunghyangjeongki-San at 30mins before MCAO and the microdialysate was collected by intracerebral microdialysis three times before MCAO and six times after MCAO at 20mins interval and analyzed by HPLC. After a microdialysis study, the brain was sliced and stained with cresyl violet buffer for the measurement of cerebral infarcted area and volume by image analyzer system Results : The concentrations of glutamate, aspartate, and tyrosine known as excitatory neurotransmitters were significantly decreased in Sunghyangjeongki-San group compared with control group, The concentrations of GABA, glycine, taurine and alanine known as inhibitory neurotransmitters were significantly increased in Sunghyangjeongki-San group compared with control group. The concentrations of pyruvate and lactate showed little significant change in Sunghyangjeongki-San group compared with control group. The measurement of cerebral infarcted area and volume by image analyzer system were significantly decreased in Sunghyangjeongki-San group compared with control group. Conclusions : Sunghyangjeongki-San can affect on protecting against cerebral ischemia by regulating extracellular levels of excitatory and inhibitory amino acid neurotransmitters and improve the conditions of the patients in the early stage of stroke.
이영순(Young Soon Lee),이상덕(Sang Deok Lee),김순재(Soon Jae Kim),박미옥(Mi Yok Park),박경열(Kyeong Yeol Park),김영호(Young Ho Kim) 한국육종학회 2009 한국육종학회지 Vol.41 No.4
러빙유 품종은 경기도농업기술원에서 2007년도에 육성한 절화용 장미 신품종이다. 이 품종은 1999년도에 화색이 적색이며 향기가 있는 스탠다드 장미 Neon 을 모본으로 하고 주황색과 살구색으로 복색이며 화형이 우수한 스탠다드 장미 Hello 를 부본으로 1999년도에 교배하였다. 2000년에 실생 을 양성하여 화색과 화형이 우수한 55계통을 예비선발 하였 으며 2005~2007년에 1, 2, 3차 특성검정과 품평회 결과 절화특성이 우수한 KR99-06-06(Gyeonggi R1-12)계통을 최종 선발하였다. 화색은 분홍색이며 스탠다드 형태로 개화하고 화형은 반고심형이며 꽃잎수는 50.2매이고 향기 정도는 중간인 편이다. 생육속도가 매우 빨라 개화소요일수는 46일로서 연간 8회 수확할 수 있다. 연간 절화수량은 108.5본/m 2 이고 절화장은 76.8 cm이며 줄기직경은 6.9 mm이고 엽수는 10.4매 이며 절화중은 51.3 g이고 절화수명은 11.0일이다. new rose cultivar was developed from a cross between Neon and Hello by the rose breeding team of Gyeonggi-Do Agricultural Research and Extension Services in 1999. The cultivar, Loving You was finally selected in 2007 after evaluation trials for three years (2005-2007). The cultivar was developed for a standard-type cut flower with pink petals. Loving You grows vigorously and produces 108.5 stems/m2 in a year, and has 50.2 petals per flower. The days to flower was 46 days, which is very short in rose. The length of cut flower was long with 76.8 cm. Vase-life of the cultivar could be as long as 11 days. The cultivar was applied for a variety protection in 2007.
3T3-L1 세포에서 소맥엽 에탄올추출물의 지질생성 억제효과
이선희(Sun-Hee Lee),신명걸(Mingjie Xin),Bui Thi Thuy Luyen,차지윤(Ji-Yun Cha),임지영(Ji-Young Im),권세욱(Se-Uk Kwon),임성원(Sung-Won Lim),서주원(Joo-Won Suh),김영호(Young-Ho Kim),김대기(Dae-Ki Kim),이영미(Young-Mi Lee) 대한약학회 2011 약학회지 Vol.55 No.6
Non-alcoholic fatty liver disease is known to be frequently associated with obesity and type 2 diabetes. We examined the effects of EtOH extracts from Triticum aestivum on lipid accumulation during the differentiation of 3T3-L1 preadipocytes to screening the candidate materials in preventing non-alcoholic fatty liver disease. The lipid level in adipocytes was determined by Oil Red O staining. The treatment of 50% ethanol, but not water and 100% ethanol extracts, from Triticum aestivum at concentration of 0.5 mg/ml inhibited lipid accumulation in 3T3-L1 cells, revealing no cell toxicity. Thus, the fractions of CH2Cl2, EtOAc and BuOH were separated from 50% EtOH extract to characterize anti-adipogenic effect. The CH2Cl2 fraction at concentration of 50 μg/ml effectively inhibited the lipid accumulation in the adipocytes compared to those of EtOAc and BuOH at concentration of 50 μg/ml. The intracellular triglyceride accumulation also was significantly reduced by treatment of CH2Cl2 fraction in concentration-dependent manner. Western blot analysis showed that the CH2Cl2 fraction attenuated the intracelluar level of fatty acid synthase(FAS) accompanied by attenuated expression of Peroxidase proliferator-activated receptor γ (PPARγ) adipogenic transcription factor. These results suggest that CH2Cl2 fraction from 50% EtOH extract of Triticum aestivum may has the potent anti-adipogenic effects by inhibiting the transactivation of PPARγ.