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가정의학과 외래 우울증환자에서 moclobemide의 안전성 및 유효성 평가를 위한 시판후조사
김영식,이근미,김병성,신호철,성은주,이상엽,문유선,송상욱,김철환,선우성,Kim, Young-Sik,Lee, Keun-Mi,Kim, Byung-Sung,Shin, Ho-Cheol,Sung, Eun-Ju,Lee, Sang-Yeoup,Moon, Yoo-Sun,Song, Sang-Wook,Kim, Cheol-Hwan,Sunwoo, Sung 대한임상약리학회 2002 臨床藥理學會誌 Vol.10 No.1
Background : Depression is quite a common disease in primary care however, studies for the safety and effectiveness of antidepressants in primary care setting are rare in Korea. Objectives : This multi-centered post-marketing study was performed to evaluate the safety and effectiveness of Moclobemide and to find out the factors related to the adherence among patients with depression in family practice. Methods : A total of 386 patients were enrolled from July 1999 to January 2000 by twenty family doctors from fifteen family practice centers. They were prescribed Moclobemide and were reevaluated at the 4th, 8th, and l2th week. Evaluation of compliance, safety and effectiveness were performed with pre-made, structured self-reported questionnaires. Evaluation of effectiveness was also performed utilizing self-rating depression scale (SDS). Results : Among 386 patients, safety was evaluated in 310 patients and effectiveness was evaluated in 239 patients. During the first 12 weeks, the number of subjects continuing with Mocclobemide was 136(37.1%). 141 subjects (38.4%) discontinued taking the drug and 90 subjects (24.5%) dropped out at the 12th week. Considering drop-out patients as ineffective cases, overall effectiveness was estimated to be 84.5%. Symptoms improved with time in patients whose follow-up were completed (P<0.01). The SDS score decreased by an average of ${6.8{\pm}9.1(12.2{\pm}19.1%)}$ after 12 weeks(p<0.01). During the study, 33(10.6%) subjects reported adverse events. The most commonly reported adverse events, in descending order, were dizziness(2.3%), headache(1.6%), insomnia(1.3%), facial edema(1.3%), constipation(1.0%), nausea(1.0%) and tremor(1.0%). The main reasons for discontinuing antidepressants were attributed to improvement of symptoms and manifestation of adverse events. Conclusion : The percentage of adherence at 12th week of Moclobemire among patients suffering from depression in the family practice outpatient clinic was shown to be 49%. The antidepressant effect and safety of Moclobemide was relatively superior.
레토르트 및 감마선 조사에 의한 화닭 덮밥 소스의 미생물 제어 효과 비교
김영식,김현주,윤요한,신명곤,김천제,신미혜,이주운,Kim, Young-Sik,Kim, Hyun-Joo,Yoon, Yo-Han,Shin, Myung-Gon,Kim, Cheon-Jei,Shin, Mee-Hye,Lee, Ju-Woon 한국축산식품학회 2010 한국축산식품학회지 Vol.30 No.1
This study evaluated the antimicrobial effects of retort process and gamma irradiation on reduction of total bacterial populations in spicy chicken sauce, which is served on top of the steamed rice. Commercial spicy chicken sauce was treated with retort and gamma ray at 0, 1, 3, 5, and 10 kGy. Total aerobic bacterial populations were then enumerated on plate count agar and isolated bacteria from the test samples were identified using PCR analysis. Moreover, gamma ray sensitivity of identified bacteria was evaluated by $D_{10}$ values, and genotoxicity of gamma-irradiated samples was examined. Gamma irradiation at 3 kGy reduced total aerobic bacterial cell counts in spicy chicken sauce below detection limit, but total aerobic bacterial cell counts in test samples treated with retort were 2.1 log CFU/g. Identified bacteria from the samples were Bacillus subtilis, B. amyloiquefaciense, and B. pumils, and the $D_{10}$ values for B. subtilis and B. cereus were 0.39 ($R^2\;=\;0.921$) and 0.28 log CFU/g ($R^2\;=\;0.904$), respectively. The SOS chromotest showed that the gamma-irradiated spicy chicken sauce did not cause mutagenicity. These results indicate that gamma irradiation of spicy chicken sauce could be useful in ensuring microbial safety.
초내열합금분말에 의한 PTA 오버레이부의 연삭 마모 특성 연구
김영식,최영국,임창훈,김종도,Kim, Young-Sik,Choi, Young-Gook,Lim, Chang-Hoon,Kim, Jong-Do 대한용접접합학회 2009 대한용접·접합학회지 Vol.27 No.3
The Plasma Transferred Arc (PTA) overlay welding method is lately introduced as one of the most useful surface overlay method of the engine component. In this paper, the overlay welding on the SNCrW heat resisting alloy was conducted by the PTA overlay welding process using the super alloy powder. The characteristics of the overlay layers were investigated through the metallurgical and abrasive test. Experimental results showed that the overlay on the SNCrW heat resisting alloy surface was successfully made without hot cracking. The friction wear characteristics of the Co-base Stellite 6 overlayer were most superior. However the abrasive wear characteristics were most inferior in the Co-base Stellite 6 overlayer.
김영식,김규광,한홍,Kim, young-Sik,Kim, Gyu-Kwang,Han, Hong 한국환경보건학회 1992 한국환경보건학회지 Vol.18 No.1
A study was performed to measure the heavy metal concentrations of suspended particles in iron castings during February, 1990. The heavy metal concentrations were analyzed using patricles atomic absorption spectrophotometer. The results were as fellows 1. The concentrations of suspended paticles by casting process were at furnace 4.19mg/m$^{3}$ at pouring 2.93mg/m$^{3}$ at nonferrous furnace 3.90mg/m$^{3}$, at molding 1.17mg/m$^{3}$, jung ja 2.23mg/m$^{3}$, desanding 5.42mg/m$^{3}$, sand treatment 4.82mg/m$^{3}$, finishing 1,20mg/m$^{3}$. 2. Among the total of 8 iron casting workplaces, the concentrations Fe of furnace was 0.36mg/m$^{3}$, Cu of nonferrous furnace 0.02mg/m$^{3}$, Pb of pouring 0.02mg/m$^{3}$, Cr of desanding 0.01mg/m$^{3}$ and Mn of furnace 0.03mg/m$^{3}$.
김영식,Kim Young-Sik 한국환경보건학회 2004 한국환경보건학회지 Vol.30 No.5
In this study, lots of methods have been studing to utilize energy and decrease contaminated effluents. There has been great progress on IGCC (Integrated gasification combined cycle) to reduce thermal energy losses. The following results have been conducted from desulfurization experiments using waste shell to remove $H_{2}S$. Unreacted core model ior desulfuriration rate prediction of sorbent was indicated. These were linear relationship between time and conversion. So co-current diffusion resistance was conducted reaction rate controlling step. The sulfidation rate is likely to be controlled primarily by countercurrent diffusion through the product layer of calcium sulfide(CaS) formed. Maximum desulfurization capacity was observed at 0.631 mm for lime, oyster and hard-shelled mussel. The kinetics of the sorption of $H_{2}S$ by CaO is sensitive to the reaction temperature and particle size at $800^{\circ}C$, and the reaction rate of oyster was faster than the calcined limestone at $700^{\circ}C$.
전단보강근이 없는 철근콘크리트보의 매립형 CFRP 전단보강효과에 대한 연구
김영식,박성무,Kim, Young-Sik,Park, Sung-Moo 한국공간구조학회 2005 한국공간구조학회지 Vol.5 No.2
철근콘크리트구조물은 시간이 경과함에 따라 노후화현상이 일어난다. 이에 갱생수단으로 보수 보강이 이루어지고 있다. 현재 보강재료로써 FRP가 높은 관심과 더불어 많은 활용을 하고 이에 대한 연구가 이루어지고 있다. 본 연구에서는 전단보강근이 없는 철근콘크리트보에 매립형 탄소섬유막대(CFRP)를 전단보강하여 그에 따른 효과를 파악하기 위해 시험체를 제작하여 실험을 수행하였다. 전단보강근이 없는 철근콘크리트보에 매립형 탄소섬유막대(CFRP)를 전단보강하여 탄소섬유막대(CFRP)의 순수전단내력을 파악하고, 전단보강에 따른 시험체의 전단파괴거동을 파악하고자 한다. 또한 실험변수를 탄소섬유막대(CFRP)의 보강량과 보강간격으로 두어, 이에 따른 전단보강효과를 파악하고자 한다. The reinforced concrete becomes deteriorated. In strengthening of reinforced concrete structure, it is recently useing FRP. The purpose of this study is to investigate the shear resisting effort of filling-up CFRP in reinforced concrete beams without web reinforced. Six specimens were manufactured and tested. In the test result, it was analysis. The main variables in the test were a space and volume of CFRP.
김영식,주영승,Kim, Young-Sik,Ju, Young-Sung 대한본초학회 2016 大韓本草學會誌 Vol.31 No.4
Objectives : This study is to propose discriminative keys with stereoscope for minute seed herbs easily mixed up, but hard to discriminate by naked eyes: Alli Tuberosi Semen(ATS)?Alli Fistulosi Semen(AFS), Malvae Semen(MS)? Abutili Semen(AS), Plantaginis Semen(PS)?Schizonepetae Semen(SS).Objectives : We reviewed the description of original plants and medicinal herbs from literature. The specimen of original plant were collected, determinated and compared to samples in the market. Primary classification was performed with naked eyes. and we found out other discrimination keys for non-distinctive herbs with stereoscope. Discrimination keys were set as the morphological criteria of authentic herbs, percentage of adulteration, and standards for discriminating genuine herbs from adulteration.Results : 1) ATS is bigger, has reticulate pattern on protuberant side and unique garlic chives taste. AFS which is usually mixed up, is smaller, has 1~2 ridges and unique welsh onion taste. 2) MS is smaller, has no villus, but its length of bumps are similar. AS easily mixed up, is bigger and has white villus. Its upper side bump is longer and more sharp. 3) PS has dent at middle of the back side. It becomes very sticky when it is put or boiled in water. SS which can be mixed up has no dent and low viscosity compared to PS.Conclusions : With this result, we propose discriminative keys which can identify the original plants and processed herbal state of six herbs. Because minute medicinal herbs are hardly distinguishable by sensory test, It is essential to differentiate by using stereoscope.